Autoantibodies.

By: Shoenfeld, YehudaContributor(s): Meroni, Pier Luigi | Gershwin, M. EricPublisher: Oxford : Elsevier, 2013Copyright date: ©2014Edition: 3rd edDescription: 1 online resource (917 pages)Content type: text Media type: computer Carrier type: online resourceISBN: 9780444593771Subject(s): Autoantibodies.;Autoimmune diseases -- EtiologyGenre/Form: Electronic books. Additional physical formats: Print version:: AutoantibodiesDDC classification: 616.978 LOC classification: QR188.3.A98 2014ebOnline resources: Click to View
Contents:
Front Cover -- Autoantibodies -- Copyright -- Dedication -- Cover image credits -- Contents -- Preface -- List of Contributors -- FOREWORD - The concept of immunodiagnosis -- Chapter 1 - The Concept of Immunodiagnosis -- Diagnosis of syphilis -- Antiphospholipid syndrome -- Rheumatoid arthritis -- Hemolytic anemias -- Systemic lupus erythematosus -- Organ-specific autoimmune diseases -- Thyroiditis -- Receptor diseases -- Remarks -- References -- PART 1 - Introduction: Autoantibodies-Unique Characteristics -- Chapter 2 - What Is an Autoantibody? -- Introduction -- Historical notes -- Tolerance and autoimmunity -- Concluding remarks -- References -- Chapter 3 - Natural Autoantibodies-Homeostasis, Autoimmunity, and Therapeutic Potential -- Historical notes -- The origin of natural autoantibodies -- Natural autoantibodies and their function in autoimmune modulation -- Natural autoantibodies as part of the innate immune system -- Apoptosis and natural autoantibodies -- Protective natural autoantibodies in immune and autoimmune homeostasis -- References -- Chapter 4 - Molecular Mimicry -- Pathogen infection as a cause for autoimmunity -- Examples of true molecular mimicry -- The concept of molecular mimicry as a basis for animal models -- Molecular mimicry: Protection of the pathogen or the host? -- Clinical utilities -- Take-home messages -- References -- Chapter 5 - Affinity and Avidity of Autoantibodies -- Historical notes -- Avidity and affinity -- Clinical utility of avidity in autoimmune disorders -- Take-home messages -- References -- Chapter 6 - Pathogenic Mechanisms and Clinical Relevance of Autoantibodies -- Historical notes -- Pathogenic mechanisms for autoantibody-mediated injury -- Clinical relevance -- Take-home messages -- References -- Chapter 7 - Predictive Autoantibodies -- Introduction -- Prediction of disease.
Prediction of disease activity and severity -- Autoantibodies as predictors of nonautoimmune diseases -- Hierarchy of autoantibodies -- Combining human leukocyte antigen and predictive antibodies in prediction -- Combining specific genes and antibody testing -- Implications and future directions -- Take-home messages -- References -- Chapter 8 - Antibodies Against Acute Phase Proteins -- Historical notes -- The autoantigens -- The autoantibodies -- Clinical utility -- Take-home messages -- References -- Chapter 9 - Idiotypes and Anti-Idiotypes -- Historical notes -- The autoantigen -- Structure of idiotypes -- Genetics -- Autoantibodies -- Physiologic role -- Pathogenic role -- Clinical utility -- Summary -- Take-home messages -- References -- Chapter 10 - Introductory Remarks for the Diagnostic and Therapeutic Applications of Monoclonal Antibodies and Various Formats -- Monoclonal antibodies -- Antibody engineering -- Clinical applications -- Take-home messages -- References -- Part 2 - Allergic Disease Autoantibodies -- Chapter 11 - Human Autoantibodies in Urticaria, Angioedema, and Other Atopic Diseases -- Historical notes -- Structure and function -- Immunoglobulin E receptors -- Galectin-3 -- Autoantibodies to immunoglobulin E and its receptors -- Clinical utility -- Conclusions -- Take-home messages -- References -- Part 3 - Antineutrophil Antibodies -- Chapter 12 - Antineutrophil Cytoplasmic Autoantibodies with Specificity for Myeloperoxidase -- Historical notes -- The autoantigen -- The autoantibodies -- Clinical utility -- Take-home messages -- References -- Chapter 13 - Antineutrophil Cytoplasmic Antibodies with Specificity for Proteinase 3 -- Historical notes -- The autoantigens -- The autoantibodies -- Clinical utility -- Take-home messages -- References.
Chapter 14 - Neutrophil-Specific Antinuclear and Anticytoplasmic Autoantibodies in Chronic Inflammatory Diseases -- Historical notes -- Methods of detection -- Standardization of indirect immunofluorescence neutrophil-specific autoantibody detection -- Autoantigens and autoantibodies -- Diagnostic utility of neutrophil-specific autoantibodies -- Diagnostic specificity of neutrophil-specific autoantibodies -- Pathogenicity -- Take-home messages -- References -- PART 4 - Introduction: Antinuclear Antibodies -- Chapter 15 - Antinuclear Antibodies: General Introduction -- Historical notes -- Methods of antinuclear antibody detection -- Clinical utility -- Open questions on antinuclear antibody testing -- Take-home messages -- References -- Chapter 16 - Autoantibodies to Survival of Motor Neuron (SMN) Complex -- Historical note -- Autoantigen -- Autoantibodies -- Clinical utility -- Take-home messages -- References -- Chapter 17 - Antinucleolar Antibodies as Diagnostic Markers in Systemic Autoimmune Diseases -- Introduction -- Polymyositis/scleroderma (PM/Scl) -- Th /  To -- U3-snoRNP antibodies (fibrillarin) -- B23 (numatrin) -- RNA polymerase antibodies -- NOR-90 (anti-hUBF) -- Other nucleolar autoantigens -- Detection methods -- References -- Chapter 18 - Anti-U1RNP and -Sm Antibodies -- Historical notes -- Autoantigens -- Autoantibodies -- Clinical utility -- Take-home messages -- References -- Chapter 19 - Antibodies to Rods and Rings -- Historical notes -- Autoantigen -- Autoantibody -- Clinical utility -- Take-home messages -- References -- Chapter 20 - Antinucleosome Autoantibodies -- Introduction -- Historical notes -- Autoantigen -- Autoantibody -- Clinical utility -- Take-home messages -- References -- Chapter 21 - Centromere Autoantibodies -- Introduction -- Anticentromeres: Methods of detection -- Clinical and demographic associations.
Anticentromeres: Association with other autoantibodies -- Anticentromeres in other connective tissue diseases -- Clinical utility -- Take-home messages -- References -- Chapter 22 - dsDNA Autoantibodies -- Historical notes -- Autoantigen -- Autoantibody -- Clinical utility -- Take-home messages -- References -- Chapter 23 - Histone Autoantibodies -- Historical notes -- Autoantigens -- Autoantibodies -- Clinical utility -- Take-home messages -- References -- Chapter 24 - Ku and Ki Autoantibodies -- Historical notes -- Autoantigens -- Autoantibodies -- Clinical utility -- Take-home messages -- References -- Chapter 25 - Neuronal Nuclear Autoantibodies, Type 1 (Hu) -- Introduction -- Historical notes -- Hu antigens -- Anti-Hu autoantibodies -- Hu-ab clinical utility -- Take-home messages -- References -- Chapter 26 - Nuclear Envelope Protein Autoantibodies/Antilamin Autoantibodies -- Historical notes -- Autoantigens -- Autoantibodies -- Take-home messages -- References -- Chapter 27 - Antiribosomal P Antibodies -- Introduction -- Prevalence -- Characteristics of ribosomal P -- Mechanisms -- Clinical implications -- Conclusion -- References -- Chapter 28 - Ro/SSA Autoantibodies -- Historical Notes -- Autoantigen -- Autoantibodies -- Conclusions -- References -- Chapter 29 - Topoisomerase I (SCL 70) Autoantibodies -- Historical notes -- Autoantigen -- Autoantibodies -- Clinical utilities -- Take-home messages -- Acknowledgments -- References -- Chapter 30 - SS-B (La) Autoantibodies -- Historical notes -- Autoantigen -- Autoantibodies -- Take-home messages -- References -- PART 5 - Autoantibodies to Biologic Factors/Structures -- Chapter 31 - Autoantibodies to GW/P Bodies and Components of the MicroRNA Pathway -- Historical notes -- Autoantigen -- Autoantibody -- Clinical utility -- Take-home messages -- References.
Chapter 32 - Golgi Complex and Endosome Antibodies -- Autoantigen -- Biological function -- Autoantibody -- Clinical utility -- Take-home messages -- References -- Chapter 33 - Tumor-Associated Autoantibodies -- Historical notes -- Autoantigenic targets of tumor-associated autoantibodies -- Relevance of tumor-associated autoantibodies -- Tumor-associated autoantibodies - biomarkers for the prediction and early diagnosis of cancer? -- Perspectives -- Take-home messages -- References -- Chapter 34 - p53 Autoantibodies -- Historical notes -- Autoantigen -- Autoantibody -- Clinical utility -- Take-home messages -- References -- 35 - Naturally Occurring Anti-HLA-E Autoantibodies: Evidences of HLA-Ia Reactivity of Anti-HLA-E Antibodies -- Evidences of HLA-Ia Reactivity of Anti-HLA-E Antibodies -- Introduction -- Anti-HLA-E Abs may account for HLA-Ia reactivity in sera -- Support for the hypothesis from anti-HLA-E IgM/IgG ratios in normal healthy sera -- Direct evidence for immunogenicity of HLA-E in humans -- Anti-HLA-E autoantibodies may account for the nondonor-specific anti-HLA class-Ia antibodies in transplant recipients -- SUMMARY: CLINICAL IMPLICATIONS AND TAKE-HOME MESSAGES -- References -- Chapter 36 - Autoantibodies in Therapeutic Preparations of Human Intravenous Immunoglobulin (IVIg) -- Historical notes -- Maintenance of immune/tissue homeostasis -- Clinical utilities -- Take-home messages -- References -- Chapter 37 - Cytoskeletal Autoantibodies/Antiactin Antibodies -- Historical notes -- Autoantigen -- Autoantibody -- Clinical utility -- Take-home messages -- References -- 38 - Fibrillarin Autoantibodies -- Historical notes -- Autoantigen -- Definition -- Biological function -- Origin/sources -- Methods of purification -- Autoantibody -- Definition -- Pathogenic role -- Genetics -- Methods of detection -- Clinical utility -- Diagnostic value.
Specificity.
Summary: Autoimmune diseases are characterized by the occurrence of antibodies reacting with self-constituents of the body. The fully updated third edition of Autoantibodies is an in-depth review of the main autoantibodies identified up to now, with particular emphasis on those that display a diagnostic or prognostic clinical value. The new edition covers recent scientific advances, diagnostic techniques, and therapeutic technologies. Each chapter is focused on a single family of autoantibodies. This important reference contains historical notes, definitions, origins and sources of antigens recognized genetic associations, mediated pathogenic mechanisms, methods of detection, as well as clinical utility (disease prevalence and association, diagnostic value, sensitivity and specificity, prognostic value). This is an ideal reference for anyone involved in the field of autoimmune diseases. Presents all known, important autoantibodies in a single source, focusing on the antibodies needed for autoimmune disorder diagnosis Includes clinical applications for each autoantibody along with general information Organized by disease and disorder type, by autoantibody family, and completely cross-referenced.
Holdings
Item type Current library Call number Status Date due Barcode Item holds
Ebrary Ebrary Afghanistan
Available EBKAF00088106
Ebrary Ebrary Algeria
Available
Ebrary Ebrary Cyprus
Available
Ebrary Ebrary Egypt
Available
Ebrary Ebrary Libya
Available
Ebrary Ebrary Morocco
Available
Ebrary Ebrary Nepal
Available EBKNP00088106
Ebrary Ebrary Sudan

Access a wide range of magazines and books using Pressreader and Ebook central.

Enjoy your reading, British Council Sudan.

Available
Ebrary Ebrary Tunisia
Available
Total holds: 0

Front Cover -- Autoantibodies -- Copyright -- Dedication -- Cover image credits -- Contents -- Preface -- List of Contributors -- FOREWORD - The concept of immunodiagnosis -- Chapter 1 - The Concept of Immunodiagnosis -- Diagnosis of syphilis -- Antiphospholipid syndrome -- Rheumatoid arthritis -- Hemolytic anemias -- Systemic lupus erythematosus -- Organ-specific autoimmune diseases -- Thyroiditis -- Receptor diseases -- Remarks -- References -- PART 1 - Introduction: Autoantibodies-Unique Characteristics -- Chapter 2 - What Is an Autoantibody? -- Introduction -- Historical notes -- Tolerance and autoimmunity -- Concluding remarks -- References -- Chapter 3 - Natural Autoantibodies-Homeostasis, Autoimmunity, and Therapeutic Potential -- Historical notes -- The origin of natural autoantibodies -- Natural autoantibodies and their function in autoimmune modulation -- Natural autoantibodies as part of the innate immune system -- Apoptosis and natural autoantibodies -- Protective natural autoantibodies in immune and autoimmune homeostasis -- References -- Chapter 4 - Molecular Mimicry -- Pathogen infection as a cause for autoimmunity -- Examples of true molecular mimicry -- The concept of molecular mimicry as a basis for animal models -- Molecular mimicry: Protection of the pathogen or the host? -- Clinical utilities -- Take-home messages -- References -- Chapter 5 - Affinity and Avidity of Autoantibodies -- Historical notes -- Avidity and affinity -- Clinical utility of avidity in autoimmune disorders -- Take-home messages -- References -- Chapter 6 - Pathogenic Mechanisms and Clinical Relevance of Autoantibodies -- Historical notes -- Pathogenic mechanisms for autoantibody-mediated injury -- Clinical relevance -- Take-home messages -- References -- Chapter 7 - Predictive Autoantibodies -- Introduction -- Prediction of disease.

Prediction of disease activity and severity -- Autoantibodies as predictors of nonautoimmune diseases -- Hierarchy of autoantibodies -- Combining human leukocyte antigen and predictive antibodies in prediction -- Combining specific genes and antibody testing -- Implications and future directions -- Take-home messages -- References -- Chapter 8 - Antibodies Against Acute Phase Proteins -- Historical notes -- The autoantigens -- The autoantibodies -- Clinical utility -- Take-home messages -- References -- Chapter 9 - Idiotypes and Anti-Idiotypes -- Historical notes -- The autoantigen -- Structure of idiotypes -- Genetics -- Autoantibodies -- Physiologic role -- Pathogenic role -- Clinical utility -- Summary -- Take-home messages -- References -- Chapter 10 - Introductory Remarks for the Diagnostic and Therapeutic Applications of Monoclonal Antibodies and Various Formats -- Monoclonal antibodies -- Antibody engineering -- Clinical applications -- Take-home messages -- References -- Part 2 - Allergic Disease Autoantibodies -- Chapter 11 - Human Autoantibodies in Urticaria, Angioedema, and Other Atopic Diseases -- Historical notes -- Structure and function -- Immunoglobulin E receptors -- Galectin-3 -- Autoantibodies to immunoglobulin E and its receptors -- Clinical utility -- Conclusions -- Take-home messages -- References -- Part 3 - Antineutrophil Antibodies -- Chapter 12 - Antineutrophil Cytoplasmic Autoantibodies with Specificity for Myeloperoxidase -- Historical notes -- The autoantigen -- The autoantibodies -- Clinical utility -- Take-home messages -- References -- Chapter 13 - Antineutrophil Cytoplasmic Antibodies with Specificity for Proteinase 3 -- Historical notes -- The autoantigens -- The autoantibodies -- Clinical utility -- Take-home messages -- References.

Chapter 14 - Neutrophil-Specific Antinuclear and Anticytoplasmic Autoantibodies in Chronic Inflammatory Diseases -- Historical notes -- Methods of detection -- Standardization of indirect immunofluorescence neutrophil-specific autoantibody detection -- Autoantigens and autoantibodies -- Diagnostic utility of neutrophil-specific autoantibodies -- Diagnostic specificity of neutrophil-specific autoantibodies -- Pathogenicity -- Take-home messages -- References -- PART 4 - Introduction: Antinuclear Antibodies -- Chapter 15 - Antinuclear Antibodies: General Introduction -- Historical notes -- Methods of antinuclear antibody detection -- Clinical utility -- Open questions on antinuclear antibody testing -- Take-home messages -- References -- Chapter 16 - Autoantibodies to Survival of Motor Neuron (SMN) Complex -- Historical note -- Autoantigen -- Autoantibodies -- Clinical utility -- Take-home messages -- References -- Chapter 17 - Antinucleolar Antibodies as Diagnostic Markers in Systemic Autoimmune Diseases -- Introduction -- Polymyositis/scleroderma (PM/Scl) -- Th /  To -- U3-snoRNP antibodies (fibrillarin) -- B23 (numatrin) -- RNA polymerase antibodies -- NOR-90 (anti-hUBF) -- Other nucleolar autoantigens -- Detection methods -- References -- Chapter 18 - Anti-U1RNP and -Sm Antibodies -- Historical notes -- Autoantigens -- Autoantibodies -- Clinical utility -- Take-home messages -- References -- Chapter 19 - Antibodies to Rods and Rings -- Historical notes -- Autoantigen -- Autoantibody -- Clinical utility -- Take-home messages -- References -- Chapter 20 - Antinucleosome Autoantibodies -- Introduction -- Historical notes -- Autoantigen -- Autoantibody -- Clinical utility -- Take-home messages -- References -- Chapter 21 - Centromere Autoantibodies -- Introduction -- Anticentromeres: Methods of detection -- Clinical and demographic associations.

Anticentromeres: Association with other autoantibodies -- Anticentromeres in other connective tissue diseases -- Clinical utility -- Take-home messages -- References -- Chapter 22 - dsDNA Autoantibodies -- Historical notes -- Autoantigen -- Autoantibody -- Clinical utility -- Take-home messages -- References -- Chapter 23 - Histone Autoantibodies -- Historical notes -- Autoantigens -- Autoantibodies -- Clinical utility -- Take-home messages -- References -- Chapter 24 - Ku and Ki Autoantibodies -- Historical notes -- Autoantigens -- Autoantibodies -- Clinical utility -- Take-home messages -- References -- Chapter 25 - Neuronal Nuclear Autoantibodies, Type 1 (Hu) -- Introduction -- Historical notes -- Hu antigens -- Anti-Hu autoantibodies -- Hu-ab clinical utility -- Take-home messages -- References -- Chapter 26 - Nuclear Envelope Protein Autoantibodies/Antilamin Autoantibodies -- Historical notes -- Autoantigens -- Autoantibodies -- Take-home messages -- References -- Chapter 27 - Antiribosomal P Antibodies -- Introduction -- Prevalence -- Characteristics of ribosomal P -- Mechanisms -- Clinical implications -- Conclusion -- References -- Chapter 28 - Ro/SSA Autoantibodies -- Historical Notes -- Autoantigen -- Autoantibodies -- Conclusions -- References -- Chapter 29 - Topoisomerase I (SCL 70) Autoantibodies -- Historical notes -- Autoantigen -- Autoantibodies -- Clinical utilities -- Take-home messages -- Acknowledgments -- References -- Chapter 30 - SS-B (La) Autoantibodies -- Historical notes -- Autoantigen -- Autoantibodies -- Take-home messages -- References -- PART 5 - Autoantibodies to Biologic Factors/Structures -- Chapter 31 - Autoantibodies to GW/P Bodies and Components of the MicroRNA Pathway -- Historical notes -- Autoantigen -- Autoantibody -- Clinical utility -- Take-home messages -- References.

Chapter 32 - Golgi Complex and Endosome Antibodies -- Autoantigen -- Biological function -- Autoantibody -- Clinical utility -- Take-home messages -- References -- Chapter 33 - Tumor-Associated Autoantibodies -- Historical notes -- Autoantigenic targets of tumor-associated autoantibodies -- Relevance of tumor-associated autoantibodies -- Tumor-associated autoantibodies - biomarkers for the prediction and early diagnosis of cancer? -- Perspectives -- Take-home messages -- References -- Chapter 34 - p53 Autoantibodies -- Historical notes -- Autoantigen -- Autoantibody -- Clinical utility -- Take-home messages -- References -- 35 - Naturally Occurring Anti-HLA-E Autoantibodies: Evidences of HLA-Ia Reactivity of Anti-HLA-E Antibodies -- Evidences of HLA-Ia Reactivity of Anti-HLA-E Antibodies -- Introduction -- Anti-HLA-E Abs may account for HLA-Ia reactivity in sera -- Support for the hypothesis from anti-HLA-E IgM/IgG ratios in normal healthy sera -- Direct evidence for immunogenicity of HLA-E in humans -- Anti-HLA-E autoantibodies may account for the nondonor-specific anti-HLA class-Ia antibodies in transplant recipients -- SUMMARY: CLINICAL IMPLICATIONS AND TAKE-HOME MESSAGES -- References -- Chapter 36 - Autoantibodies in Therapeutic Preparations of Human Intravenous Immunoglobulin (IVIg) -- Historical notes -- Maintenance of immune/tissue homeostasis -- Clinical utilities -- Take-home messages -- References -- Chapter 37 - Cytoskeletal Autoantibodies/Antiactin Antibodies -- Historical notes -- Autoantigen -- Autoantibody -- Clinical utility -- Take-home messages -- References -- 38 - Fibrillarin Autoantibodies -- Historical notes -- Autoantigen -- Definition -- Biological function -- Origin/sources -- Methods of purification -- Autoantibody -- Definition -- Pathogenic role -- Genetics -- Methods of detection -- Clinical utility -- Diagnostic value.

Specificity.

Autoimmune diseases are characterized by the occurrence of antibodies reacting with self-constituents of the body. The fully updated third edition of Autoantibodies is an in-depth review of the main autoantibodies identified up to now, with particular emphasis on those that display a diagnostic or prognostic clinical value. The new edition covers recent scientific advances, diagnostic techniques, and therapeutic technologies. Each chapter is focused on a single family of autoantibodies. This important reference contains historical notes, definitions, origins and sources of antigens recognized genetic associations, mediated pathogenic mechanisms, methods of detection, as well as clinical utility (disease prevalence and association, diagnostic value, sensitivity and specificity, prognostic value). This is an ideal reference for anyone involved in the field of autoimmune diseases. Presents all known, important autoantibodies in a single source, focusing on the antibodies needed for autoimmune disorder diagnosis Includes clinical applications for each autoantibody along with general information Organized by disease and disorder type, by autoantibody family, and completely cross-referenced.

Description based on publisher supplied metadata and other sources.

Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2019. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.

There are no comments on this title.

to post a comment.