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Intro -- CONTENTS -- Contributors -- Chapter 1 Fibrocytes: Discovery of a Circulating Connective Tissue Cell Progenitor Richard Bucala -- Introduction -- Phenotypic Properties -- Functional Roles in Wound Repair -- Role in Health and Disease -- Wound Repair -- Tumor Biology -- Immunostimulatory Properties -- Infectious Diseases -- Scleroderma -- Nephrogenic Systemic Fibrosis (NSF) -- Asthma, Acute Lung Injury, and Pulmonary Fibrosis -- Conclusions -- Acknowledgments -- References -- Chapter 2 Fibrocytes: Immunologic Features Jason Chesney -- Introduction -- Requirement of T Cells for the Development of Fibrosis -- T Cell-mediated Fibrosis in Human Disease -- Fibrocytes -- Fibrocytes are Potent Antigen Presenting Cells -- Fibrocytes Secrete Type I Collagen and Inflammatory Cytokines -- Conclusion -- References -- Chapter 3 Regulatory Pathways for Fibrocyte Differentiation Darrell Pilling and Richard H. Gomer -- Introduction -- Biology of the Monocyte-Macrophage System -- Differentiation of Monocytes into Cell Types Other than Macrophages -- Peripheral Blood Mononuclear Cells can also Differentiate into Fibroblast/Stromal Cells -- Soluble Factors that Regulate Fibrocyte Differentiation -- Regulation of Fibrocytes by Glucose and Insulin -- Regulation of Fibrocyte Differentiation by SAP and Aggregated IgG -- Regulation of Fibrocyte Differentiation by T cells and Extracellular Matrix -- Summary -- Acknowledgments -- References -- Chapter 4 Hematopoietic Origin of Fibrocytes Amanda C. LaRue and Makio Ogawa -- Introduction -- Fibroblast Precursors -- Clonal Transplantation -- HSC Origin of Fibroblasts -- Perspectives -- Acknowledgments -- References -- Chapter 5 The Role of Fibrocytes in Post-burn Hypertrophic Scarring JianFei Wang, Yaujiong Wu, Abelardo Medina, Paul. G. Scott and Edward E. Tredget -- Introduction.
Altered Structure and Composition of the Extracellular Matrix of Hypertrophic Scars -- A Th2 Polarized Immune Response in Hypertrophic Scar -- Dysregulated Apoptosis in Hypertrophic Scar -- Apoptosis in the Resolution of Inflammation -- Delayed Fibroblast and Myofibroblast Apoptosis in Hypertrophic Scar -- Increased Levels of the Profibrotic Growth Factors TGF-ß and CTGF in Hypertrophic Scar -- Hypertrophic Scarring is Associated with Blood Borne Fibrocytes -- Increased Numbers of Fibrocytes can be Cultured from the Blood of Burn Patients -- Establishment of LSP-I as a Fibrocyte Marker -- Increased Numbers of Fibrocytes in Post-burn Hypertrophic Scar -- Potential Interaction of Fibrocytes and Endothelial Cells -- Possible Interactions of Fibrocytes and Fibroblasts -- Elevated TGF-β and CTGF mRNA Levels in Burn Patient Fibrocytes -- Fibrocytes may Contribute to the Myofibroblast Population -- Possible Role of Fibrocytes in the Polarized Th2 Immune Response -- Proposed Role of Fibrocytes in Hypertrophic Scar Formation -- Summary and Prospects for Future Work -- Acknowledgments -- References -- Chapter 6 Role in Asthmatic Lung Disease Sabrina Mattoli and Matthias Schmidt -- Introduction -- Phenotypic and Functional Characteristics of Fibrocytes -- Differentiation of Fibrocytes at the Tissue Sites -- Fibrocytes in Asthma -- Fibrocytes in Asthma Models -- Potential Fibrocyte Chemoattractants in Asthma -- Conclusions -- References -- Chapter 7 Fibrocytes and Other Fibroblast/Myofibroblast Progenitors in Systemic Sclerosis Arnold E. Postlethwaite -- Systemic Sclerosis Clinical Characteristics -- The Vasculature in SSc -- The Immune System in SSc -- The Fibroblast Phenotype in SSc -- Accumulation of T cells, Monocytes and Mast Cells in Clinically Involved Skin in SSc.
Relationship of Autoimmunity, Vascular Abnormalities and Fibrosis in SSc (the Old Paradigm) -- Possible Alternative Sources of Fibroblasts in SSc -- Resident Fibroblast Progenitors -- Fibroblast Progenitors from the Circulation in Patients with SSc and Related Fibrotic Conditions -- Circulating Fibrocytes and other Progenitors of Fibroblast-like Cells (FLC) -- Overall Hypothetical Scheme for Pathogenesis of SSc -- New Treatment Strategies for SSc based on Circulating Fibroblast Progenitors -- References -- Chapter 8 Fibrocytes in Interstitial Lung Disease Brigitte N. Gomperts and Robert M. Strieter -- Introduction -- The Fibrocyte is a Unique Cell Population that has been Implicated in Wound Repair -- Fibrocyte Trafficking -- The Fibrocyte Demonstrates Plasticity Compatible with the Concept of an Adult Stem Cell/Progenitor Cell -- Fibrocytes in Pulmonary Fibrosis -- Pulmonary Fibrosis -- The Origin of the Fibroblast/Myofibroblast: A Pivotal Cell in Mediating Fibroproliferation in Pulmonary Fibrosis -- Fibrocytes in Asthma -- Repair and Remodeling of the Airway in Asthma -- Fibrocytes in Airway Remodeling in Asthma -- Fibrocytes in Pulmonary Vascular Remodeling -- Conclusions -- References -- Chapter 9 Role of Fibrocytes in Renal Fibrosis Norihiko Sakai, Takashi Wada, Kouji Matsushima and Shuichi Kaneko -- Introduction -- Fibrocytes in an Experimental Renal Fibrosis Model -- 1) Presence of fibrocytes in fibrotic kidneys -- 2) CCL21/CCR7 signaling regulates fibrocyte infiltration and renal fibrosis -- 3) Infiltration routes of fibrocytes to fibrotic kidneys -- 4) Effect of blockade of CCL21/CCR7 signaling on expression of renal monocyte chemoattractant protein-I (MCP-1/CCL2) and infiltration of F4/80-positive macrophages -- Fibrocytes in Human Renal Diseases -- Concluding Remarks -- References.
Chapter 10 Role of Fibrocytes in Atherogenesis Heather Medbury -- Introduction -- Atherosclerosis: The Perpetual Wound -- Inflammation: Fatty Core Development -- Tissue Formation/Remodeling: Development of the Fibrous Cap -- Plaque Rupture -- TGF-β: The Key Factor -- Fibrocytes: Friend or Foe in Atherosclerosis -- Monocytes: A Source of Fibrocytes -- Intimal Hyperplasia -- Conclusion -- References -- Chapter 11 Nephrogenic Systemic Fibrosis: A Prototype Fibrocyte Disease Cynthia L. Kucher and Shawn E. Cowper -- Introduction -- Historical Context -- The Affected Population -- Renal Disease -- Dialysis -- Renal transplantation -- Other Comorbidities -- Hypercoagulability, thrombosis, and endothelial injury -- Other systemic processes -- Presentation -- Signs, Symptoms and Progression -- Diagnosis -- Laboratory investigation -- Biopsy and histopathology -- Ancillary studies -- Treatment -- Renal transplantation -- Extracorporeal photopheresis (ECP) -- Plasmapheresis -- Other considerations -- Discussion -- Circulating Fibrocytes -- A basic conceptual model and possible triggers -- The newest suspect: Endothelin-I -- Fibrosis via accretion - a proposal -- Fibrosis via exogenous substances - an alternate hypothesis -- Acknowledgment -- References -- Chapter 12 CD34+ Fibrocytes in Normal and Neoplastic Human Tissues Peter J Barth -- Introduction -- Normal CD34+ Fibrocytes - Morphology -- CD34+ Fibrocytes in the Carcinoma-associated Stroma -- Pathogenesis of CD34+ Fibrocyte Loss -- Diagnostic Significance of CD34+ Fibrocytes -- Tumors Histogenetically Linked to CD34+ Fibrocytes -- Solitary Fibrous Tumor (SFT) -- Dermatofibrosarcoma Protuberans (DFSP) -- Stromal Tumors of the Breast -- Lipomatous Tumors -- Miscellaneous Tumors -- Gastrointestinal Stromal Tumors -- Concluding Remarks and Future Perspectives -- References -- Index.
Key Features:The first comprehensive review of fibrocyte biology in health and diseaseEdited by the scientist responsible for the discovery of fibrocytes, and written by the leading researchers in the fieldSelf-contained, with important data and methods - greatly reducing time-consuming reference searchGoes beyond the limitations of published research reports and integrates new knowledge in the broader context of stem cell and progenitor biology.
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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2019. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.