Primer on the Autonomic Nervous System.

By: Robertson, DavidContributor(s): Low, Phillip A | Polinsky, Ronald J | Low, Phillip A | Robertson, David | Paton, Julian F RPublisher: Burlington : Elsevier Science & Technology, 2004Copyright date: ©2004Edition: 2nd edDescription: 1 online resource (489 pages)Content type: text Media type: computer Carrier type: online resourceISBN: 9780080473963Subject(s): Autonomic nervous system--DiseasesGenre/Form: Electronic books. Additional physical formats: Print version:: Primer on the Autonomic Nervous SystemDDC classification: 612.8/9 LOC classification: RC407.P75 2004Online resources: Click to View
Contents:
Front Cover -- Primer on the Autonomic Nervous System -- Copyright Page -- Contents -- List of Contributors -- Preface -- PART I: ANATOMY -- Chapter 1. Development of the Autonomic Nervous System -- Pathways and Fate of Neural Crest Cells -- Factors Operating during Neural Crest Migration -- Neurite Outgrowth and Target Contact -- Factors Involved in Neurite Outgrowth and Neuronal Survival -- Synapse Formation and Neuronal Differentiation -- Conclusions -- Chapter 2. Mechanisms of Differentiation of Autonomic Neurons -- The Autonomic Nervous System Is Derived from Neural Crest Cells -- Signaling Molecules Regulate the Developmental Processes of the Autonomic Nervous System -- Transcriptional Code Underlying the Development and Phenotypic Specification of the Autonomic Nervous System -- Neurotransmitter Phenotypes of the Autonomic Nervous System -- Noradrenaline Phenotype -- Control Mechanism of DBH Gene Expression Is Closely Related to Autonomic Nervous System Development -- Cholinergic Phenotype and the Switch of Neurotransmitter Phenotypes by the Target Cell Interactions -- Chapter 3. Milestones in Autonomic Research -- Receptors -- Varicosities -- PART II: PHARMACOLOGY -- Chapter 4. Central Autonomic Control -- Anatomy of Central Autonomic Areas -- Levels of Integration of Central Autonomic Control -- Chapter 5. Peripheral Autonomic Nervous System -- Sympathetic Nervous System -- Sympathoadrenal Axis and the Adrenal Gland -- Parasympathetic Nervous System -- The Concept of Plurichemical Transmission and Chemical Coding -- Functional Neuroanatomy and Biochemical Pharmacology -- Chapter 6. The Autonomic Neuroeffector Junction -- Structure of the Autonomic Neuromuscular Junction -- Autonomic Neurotransmission -- Model of Autonomic Neuroeffector Junction -- Chapter 7. Autonomic Neuromuscular Transmission.
New Transmitters and the Concept of Cotransmitters -- Varicosities, Vesicle-Associated Proteins, and Calcium Fluxes -- Ionotropic Receptors Are Localized to the Muscle Membrane at Varicosities -- Metabotropic and Ionotropic Receptors Are Internalized and Recycled after Binding Transmitter -- Sources of Intracellular Calcium in Smooth Muscle for Initiating Contraction -- Modulation of Calcium Influx and the Control of Hypertension -- Chapter 8. Dopaminergic Neurotransmission -- Transmitter Neurochemistry -- Future Questions -- Chapter 9. Dopamine Receptors -- Structural and Functional Characteristics of Dopamine Receptors -- Signal Transduction -- Pharmacology -- Distribution -- Distribution in the Brain -- Dopamine Receptors in the Periphery -- Regulation -- Chapter 10. Noradrenergic Neurotransmission -- Noradrenergic Innervation of the Cardiovascular System -- Norepinephrine: The Sympathetic Neurotransmitter -- Storage -- Release -- Disposition -- Chapter 11. α1-Adrenergic Receptors -- Subtypes -- Structure and Signaling -- Ligand Binding and Activation -- Regulation -- Vascular Subtypes -- Chapter 12. α2-Adrenergic Receptors -- Chapter 13. β-Adrenergic Receptors -- Signaling of β-AR Subtypes -- Regulation of β-AR Function -- Polymorphisms of β-AR -- Chapter 14. Purinergic Neurotransmission -- Sympathetic Nerves -- Parasympathetic Nerves -- Sensory-Motor Nerves -- Intramural (Intrinsic) Nerves -- Skeletal Neuromuscular Junctions -- Synaptic Purinergic Transmission in Ganglia and Brain -- Plasticity of Expression of Purinergic Cotransmitters -- Long-Term (Trophic) Signaling -- P2X3 Receptors and Nociception -- Future Developments -- Chapter 15. Adenosine Receptors and Autonomic Regulation -- Postsynaptic Antiadrenergic Effects of Adenosine -- Presynaptic Effects of Adenosine on Efferent Nerves and Ganglionic Transmission.
Adenosine and Central Autonomic Regulation -- Neuroexcitatory Actions of Adenosine on Afferent Pathways -- Integrated View of Adenosine and Cardiovascular Autonomic Regulation -- Chapter 16. Acetylcholine and Muscarinic Receptors -- Acetylcholine Synthesis and Metabolism: Drug Mechanisms -- Acetylcholine Receptors -- Muscarinic Agonists -- Muscarinic Autonomic Effects of Acetylcholine -- Muscarinic Antagonists -- Chapter 17. Nicotinic Acetylcholine Receptors: Structure and Functional Properties -- Structural Considerations -- Subtype Diversity of Nicotinic Receptors -- Electrophysiologic Events Associated with Receptor Activation -- Distribution of Nicotinic Receptors -- Chapter 18. Acetylcholinesterase and Its Inhibitors -- Mechanism of Action -- Acetylcholinesterase Inhibitors -- Pharmacologic Actions of Acetylcholinesterase Inhibition -- Clinical Applications of Anticholinesterases -- Cholinesterase Inhibitors and Alzheimer's Disease -- Chapter 19. Amino Acid Neurotransmission -- Chapter 20. Peptidergic Neurotransmission -- Families of Peptide Transmitters -- Generic Features of Peptidergic Transmission -- Chemical Coding -- Overview of Peptides in the Autonomic Nervous System -- Chapter 21. Leptin Signaling in the Central Nervous System -- Central Neural Action of Leptin -- Intracellular Mechanisms of Leptin Signaling -- Site of Leptin Action in the Brain -- Interaction of Leptin and Neuropeptides in the Hypothalamus -- Conclusion -- Chapter 22. Nitrergic Neurotransmission -- Synthesis of Nitric Oxide -- Mechanisms of Nitrergic Neurotransmission -- Nitrergic Neurotransmission in the Autonomic Nervous System and Pathologic Implications -- Chapter 23. Serotonin Receptors and Neurotransmission -- Localization -- Synthesis and Metabolism -- Neurotransmission -- Receptors -- Pharmacology and Role in Disease.
Chapter 24. Antidepressant-Sensitive Norepinephrine Transporters: Structure and Regulation -- PART III: PHYSIOLOGY -- Chapter 25. Cardiac and Other Visceral Afferents -- Anatomic Framework -- Afferent Stimuli -- Autonomic Reflex Responses to Visceral Afferent Activation -- Pathologic Alterations of Visceral Afferents -- Chapter 26. Skeletal Muscle Afferents -- Chapter 27. Entrainment of Sympathetic Rhythms -- Sympathetic Rhythm -- Cardiac- and Respiratory-Related Rhythms -- Mechanisms Underlying Rhythms -- How Many Central Oscillators? -- Functional Significance -- Chapter 28. Sexual Function -- Peripheral Structures -- Central Nervous System -- Physiologic Events -- Chapter 29. Gastrointestinal Function -- Salivary Secretion -- Gastric Secretion -- Pancreaticobiliary Secretion -- Bile -- Intestinal Secretion and Absorption -- Control of Gut Motility -- Normal Gastrointestinal Motor Function -- Chapter 30. Regulation of Metabolism -- Catecholamines and Glucose Metabolism -- Catecholamines and Fat Metabolism -- Catecholamines and Thermogenesis -- Insulin and Autonomic Function -- Chapter 31. The Sweat Gland -- Anatomy and Function of the Sweat Gland -- Innervation of Sweat Gland -- Chapter 32. Temperature Regulation -- Central Integration -- Effector Mechanisms -- Shivering -- Nonshivering Thermogenesis -- Vasomotor Response -- Sudomotor Response -- Chapter 33. Autonomic Control of Airways -- Overview of Airway Innervation -- Afferent Nerves -- Cholinergic Nerves -- Bronchodilator Nerves -- Neuropeptides -- Neural Control of Airways in Disease -- Chapter 34. Autonomic Control of Cardiac Function -- Autonomic Nerves Innervating the Mammalian Heart -- Myocardial Nerve Terminals -- The Autonomic Nervous System and Cardiac Function -- Interactions between Sympathetic and Parasympathetic Nerves -- Chapter 35. Neurogenic Control of Blood Vessels.
Sympathetic Component -- Parasympathetic Component -- Neural Control of Veins -- Differential Vasomotor Control -- Chapter 36. Cerebral Circulation: Autonomic Influences -- Neural Innervation of Brain Circulation -- Extrinsic Neural Influences -- Chapter 37. High-Pressure and Low-Pressure Baroreflexes -- Anatomy -- Transduction -- Methods for Study of Human Baroreflexes -- Integrated Baroreflex Responses -- Baroreflex Resetting -- Cardiopulmonary Baroreflexes -- Summary -- Chapter 38. Venoarteriolar Reflex -- Skin Blood Flow -- Venoarteriolar Reflex -- Chapter 39. The Cardioinhibitory Vasodepressor Reflex -- Physiology -- Clinical Conditions Predisposing to Activation of the Reflex -- Chapter 40. Autonomic Control of the Kidney -- Innervation of the Kidney -- Autonomic Receptors in the Kidney -- Reflex Regulation of Blood Volume -- The Renorenal Reflex -- Autonomic Control of the Kidney in Pathophysiologic States -- Chapter 41. Autonomic Control of the Pupil -- Parasympatholytic (Anticholinergic) Drugs -- Parasympathomimetic (Cholinergic) Drugs -- Sympathomimetic (Adrenergic) Drugs -- Iris Pigment and Pupillary Response to Drugs -- Chapter 42. Intraocular Pressure and Autonomic Dysfunction -- Systemic Blood Pressure and Intraocular Pressure Relation -- Ocular Blood Flow -- Autonomic Dysfunction -- Chapter 43. Angiotensin II/Autonomic Interactions -- Sympathetic Nervous System -- Parasympathetic Nervous System -- Physiologic Examples of Regulation/Interactions -- Pathophysiology -- Conclusions -- Chapter 44. Autonomic Effects of Anesthesia -- Direct Effects of Anesthetics on Sympathetic Outflow -- Human Baroreflex Function and Anesthetic Gases -- Chapter 45. Peripheral Dopamine Systems -- Dopamine in the Kidneys -- Dopamine in the Gastrointestinal Tract -- Diet and Dopamine Sulfate -- Perspectives -- Chapter 46. Dopamine Mechanisms in the Kidney.
Renal Dopamine Formation and Excretion.
Summary: The Primer on the Autonomic Nervous System presents, in a readable and accessible format, key information about how the autonomic nervous system controls the body, particularly in response to stress. It represents the largest collection of world-wide autonomic nervous system authorities ever assembled in one book. It is especially suitable for students, scientists and physicians seeking key information about all aspects of autonomic physiology and pathology in one convenient source. Providing up-to-date knowledge about basic and clinical autonomic neuroscience in a format designed to make learning easy and fun, this book is a must-have for any neuroscientist's bookshelf! * Greatly amplified and updated from previous edition including the latest developments in the field of autonomic cardiovascular regulation and neuroscience * Provides key information about all aspects of autonomic physiology and pathology * Discusses stress and how its effects on the body are mediated * Compiles contributions by over 140 experts on the autonomic nervous system.
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Front Cover -- Primer on the Autonomic Nervous System -- Copyright Page -- Contents -- List of Contributors -- Preface -- PART I: ANATOMY -- Chapter 1. Development of the Autonomic Nervous System -- Pathways and Fate of Neural Crest Cells -- Factors Operating during Neural Crest Migration -- Neurite Outgrowth and Target Contact -- Factors Involved in Neurite Outgrowth and Neuronal Survival -- Synapse Formation and Neuronal Differentiation -- Conclusions -- Chapter 2. Mechanisms of Differentiation of Autonomic Neurons -- The Autonomic Nervous System Is Derived from Neural Crest Cells -- Signaling Molecules Regulate the Developmental Processes of the Autonomic Nervous System -- Transcriptional Code Underlying the Development and Phenotypic Specification of the Autonomic Nervous System -- Neurotransmitter Phenotypes of the Autonomic Nervous System -- Noradrenaline Phenotype -- Control Mechanism of DBH Gene Expression Is Closely Related to Autonomic Nervous System Development -- Cholinergic Phenotype and the Switch of Neurotransmitter Phenotypes by the Target Cell Interactions -- Chapter 3. Milestones in Autonomic Research -- Receptors -- Varicosities -- PART II: PHARMACOLOGY -- Chapter 4. Central Autonomic Control -- Anatomy of Central Autonomic Areas -- Levels of Integration of Central Autonomic Control -- Chapter 5. Peripheral Autonomic Nervous System -- Sympathetic Nervous System -- Sympathoadrenal Axis and the Adrenal Gland -- Parasympathetic Nervous System -- The Concept of Plurichemical Transmission and Chemical Coding -- Functional Neuroanatomy and Biochemical Pharmacology -- Chapter 6. The Autonomic Neuroeffector Junction -- Structure of the Autonomic Neuromuscular Junction -- Autonomic Neurotransmission -- Model of Autonomic Neuroeffector Junction -- Chapter 7. Autonomic Neuromuscular Transmission.

New Transmitters and the Concept of Cotransmitters -- Varicosities, Vesicle-Associated Proteins, and Calcium Fluxes -- Ionotropic Receptors Are Localized to the Muscle Membrane at Varicosities -- Metabotropic and Ionotropic Receptors Are Internalized and Recycled after Binding Transmitter -- Sources of Intracellular Calcium in Smooth Muscle for Initiating Contraction -- Modulation of Calcium Influx and the Control of Hypertension -- Chapter 8. Dopaminergic Neurotransmission -- Transmitter Neurochemistry -- Future Questions -- Chapter 9. Dopamine Receptors -- Structural and Functional Characteristics of Dopamine Receptors -- Signal Transduction -- Pharmacology -- Distribution -- Distribution in the Brain -- Dopamine Receptors in the Periphery -- Regulation -- Chapter 10. Noradrenergic Neurotransmission -- Noradrenergic Innervation of the Cardiovascular System -- Norepinephrine: The Sympathetic Neurotransmitter -- Storage -- Release -- Disposition -- Chapter 11. α1-Adrenergic Receptors -- Subtypes -- Structure and Signaling -- Ligand Binding and Activation -- Regulation -- Vascular Subtypes -- Chapter 12. α2-Adrenergic Receptors -- Chapter 13. β-Adrenergic Receptors -- Signaling of β-AR Subtypes -- Regulation of β-AR Function -- Polymorphisms of β-AR -- Chapter 14. Purinergic Neurotransmission -- Sympathetic Nerves -- Parasympathetic Nerves -- Sensory-Motor Nerves -- Intramural (Intrinsic) Nerves -- Skeletal Neuromuscular Junctions -- Synaptic Purinergic Transmission in Ganglia and Brain -- Plasticity of Expression of Purinergic Cotransmitters -- Long-Term (Trophic) Signaling -- P2X3 Receptors and Nociception -- Future Developments -- Chapter 15. Adenosine Receptors and Autonomic Regulation -- Postsynaptic Antiadrenergic Effects of Adenosine -- Presynaptic Effects of Adenosine on Efferent Nerves and Ganglionic Transmission.

Adenosine and Central Autonomic Regulation -- Neuroexcitatory Actions of Adenosine on Afferent Pathways -- Integrated View of Adenosine and Cardiovascular Autonomic Regulation -- Chapter 16. Acetylcholine and Muscarinic Receptors -- Acetylcholine Synthesis and Metabolism: Drug Mechanisms -- Acetylcholine Receptors -- Muscarinic Agonists -- Muscarinic Autonomic Effects of Acetylcholine -- Muscarinic Antagonists -- Chapter 17. Nicotinic Acetylcholine Receptors: Structure and Functional Properties -- Structural Considerations -- Subtype Diversity of Nicotinic Receptors -- Electrophysiologic Events Associated with Receptor Activation -- Distribution of Nicotinic Receptors -- Chapter 18. Acetylcholinesterase and Its Inhibitors -- Mechanism of Action -- Acetylcholinesterase Inhibitors -- Pharmacologic Actions of Acetylcholinesterase Inhibition -- Clinical Applications of Anticholinesterases -- Cholinesterase Inhibitors and Alzheimer's Disease -- Chapter 19. Amino Acid Neurotransmission -- Chapter 20. Peptidergic Neurotransmission -- Families of Peptide Transmitters -- Generic Features of Peptidergic Transmission -- Chemical Coding -- Overview of Peptides in the Autonomic Nervous System -- Chapter 21. Leptin Signaling in the Central Nervous System -- Central Neural Action of Leptin -- Intracellular Mechanisms of Leptin Signaling -- Site of Leptin Action in the Brain -- Interaction of Leptin and Neuropeptides in the Hypothalamus -- Conclusion -- Chapter 22. Nitrergic Neurotransmission -- Synthesis of Nitric Oxide -- Mechanisms of Nitrergic Neurotransmission -- Nitrergic Neurotransmission in the Autonomic Nervous System and Pathologic Implications -- Chapter 23. Serotonin Receptors and Neurotransmission -- Localization -- Synthesis and Metabolism -- Neurotransmission -- Receptors -- Pharmacology and Role in Disease.

Chapter 24. Antidepressant-Sensitive Norepinephrine Transporters: Structure and Regulation -- PART III: PHYSIOLOGY -- Chapter 25. Cardiac and Other Visceral Afferents -- Anatomic Framework -- Afferent Stimuli -- Autonomic Reflex Responses to Visceral Afferent Activation -- Pathologic Alterations of Visceral Afferents -- Chapter 26. Skeletal Muscle Afferents -- Chapter 27. Entrainment of Sympathetic Rhythms -- Sympathetic Rhythm -- Cardiac- and Respiratory-Related Rhythms -- Mechanisms Underlying Rhythms -- How Many Central Oscillators? -- Functional Significance -- Chapter 28. Sexual Function -- Peripheral Structures -- Central Nervous System -- Physiologic Events -- Chapter 29. Gastrointestinal Function -- Salivary Secretion -- Gastric Secretion -- Pancreaticobiliary Secretion -- Bile -- Intestinal Secretion and Absorption -- Control of Gut Motility -- Normal Gastrointestinal Motor Function -- Chapter 30. Regulation of Metabolism -- Catecholamines and Glucose Metabolism -- Catecholamines and Fat Metabolism -- Catecholamines and Thermogenesis -- Insulin and Autonomic Function -- Chapter 31. The Sweat Gland -- Anatomy and Function of the Sweat Gland -- Innervation of Sweat Gland -- Chapter 32. Temperature Regulation -- Central Integration -- Effector Mechanisms -- Shivering -- Nonshivering Thermogenesis -- Vasomotor Response -- Sudomotor Response -- Chapter 33. Autonomic Control of Airways -- Overview of Airway Innervation -- Afferent Nerves -- Cholinergic Nerves -- Bronchodilator Nerves -- Neuropeptides -- Neural Control of Airways in Disease -- Chapter 34. Autonomic Control of Cardiac Function -- Autonomic Nerves Innervating the Mammalian Heart -- Myocardial Nerve Terminals -- The Autonomic Nervous System and Cardiac Function -- Interactions between Sympathetic and Parasympathetic Nerves -- Chapter 35. Neurogenic Control of Blood Vessels.

Sympathetic Component -- Parasympathetic Component -- Neural Control of Veins -- Differential Vasomotor Control -- Chapter 36. Cerebral Circulation: Autonomic Influences -- Neural Innervation of Brain Circulation -- Extrinsic Neural Influences -- Chapter 37. High-Pressure and Low-Pressure Baroreflexes -- Anatomy -- Transduction -- Methods for Study of Human Baroreflexes -- Integrated Baroreflex Responses -- Baroreflex Resetting -- Cardiopulmonary Baroreflexes -- Summary -- Chapter 38. Venoarteriolar Reflex -- Skin Blood Flow -- Venoarteriolar Reflex -- Chapter 39. The Cardioinhibitory Vasodepressor Reflex -- Physiology -- Clinical Conditions Predisposing to Activation of the Reflex -- Chapter 40. Autonomic Control of the Kidney -- Innervation of the Kidney -- Autonomic Receptors in the Kidney -- Reflex Regulation of Blood Volume -- The Renorenal Reflex -- Autonomic Control of the Kidney in Pathophysiologic States -- Chapter 41. Autonomic Control of the Pupil -- Parasympatholytic (Anticholinergic) Drugs -- Parasympathomimetic (Cholinergic) Drugs -- Sympathomimetic (Adrenergic) Drugs -- Iris Pigment and Pupillary Response to Drugs -- Chapter 42. Intraocular Pressure and Autonomic Dysfunction -- Systemic Blood Pressure and Intraocular Pressure Relation -- Ocular Blood Flow -- Autonomic Dysfunction -- Chapter 43. Angiotensin II/Autonomic Interactions -- Sympathetic Nervous System -- Parasympathetic Nervous System -- Physiologic Examples of Regulation/Interactions -- Pathophysiology -- Conclusions -- Chapter 44. Autonomic Effects of Anesthesia -- Direct Effects of Anesthetics on Sympathetic Outflow -- Human Baroreflex Function and Anesthetic Gases -- Chapter 45. Peripheral Dopamine Systems -- Dopamine in the Kidneys -- Dopamine in the Gastrointestinal Tract -- Diet and Dopamine Sulfate -- Perspectives -- Chapter 46. Dopamine Mechanisms in the Kidney.

Renal Dopamine Formation and Excretion.

The Primer on the Autonomic Nervous System presents, in a readable and accessible format, key information about how the autonomic nervous system controls the body, particularly in response to stress. It represents the largest collection of world-wide autonomic nervous system authorities ever assembled in one book. It is especially suitable for students, scientists and physicians seeking key information about all aspects of autonomic physiology and pathology in one convenient source. Providing up-to-date knowledge about basic and clinical autonomic neuroscience in a format designed to make learning easy and fun, this book is a must-have for any neuroscientist's bookshelf! * Greatly amplified and updated from previous edition including the latest developments in the field of autonomic cardiovascular regulation and neuroscience * Provides key information about all aspects of autonomic physiology and pathology * Discusses stress and how its effects on the body are mediated * Compiles contributions by over 140 experts on the autonomic nervous system.

Description based on publisher supplied metadata and other sources.

Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2019. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.

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