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Hepatitis C Virus : From Laboratory to Clinic.

By: Publisher: Cambridge : Cambridge University Press, 2002Copyright date: ©2002Description: 1 online resource (272 pages)Content type:
  • text
Media type:
  • computer
Carrier type:
  • online resource
ISBN:
  • 9780511157349
Subject(s): Genre/Form: Additional physical formats: Print version:: Hepatitis C Virus : From Laboratory to ClinicDDC classification:
  • 616.3623
LOC classification:
  • RC848.H425 F45 2002
Online resources:
Contents:
Cover -- Half-title -- Title -- Copyright -- Dedication -- Contents -- Preface -- Foreword -- Abbreviations -- Part I Basic principles -- 1 Background -- 1.1 The enigma of non-A, non-B hepatitis -- 1.2 The chimpanzee as a model of non-A non-B infection -- 1.3 Surrogate markers -- 1.4 The discovery of hepatitis C virus -- 1.5 The detection of viral antibodies -- 1.6 Testing for hepatitis C RNA -- 2 The virus -- 2.1 Physical characteristics of the virus -- 2.2 Genome structure and organization -- 2.3 The 5' untranslated region -- 2.4 Polyprotein processing and virus maturation -- 2.5 Gene expression and replication -- 3 Epidemiology and transmission -- 3.1 Seroprevalenc and burden of infection -- 3.2 Genotypes and subtypes -- 3.3 Prevention of infection -- 4 Natural history of infection -- 5 Pathogenesis of infection -- 5.1 Is hepatitis C cytopathic? -- 5.2 Immunopathology -- 5.3 Virus-specific B cell responses -- 5.4 Virus-specific T cell responses -- 6 Hepatitis C and hepatocellular carcinoma -- 6.1 Prevalenc and risk factors -- 6.2 Putative direct mechanisms of hepatitis C-mediated hepatocarcinogenesis -- 6.3 Subtypes of hepatitis C and hepatocellular carcinoma -- 6.4 Other mechanisms that may contribute to hepatocellular carcinoma associated with hepatitis C -- 7 Hepatitis C and autoimmune diseases -- 8 Clinical aspects of the disease -- 9 Current therapeutic approaches -- 10 Nonstructural protein 5A and interferon resistance -- Part II Recent advances -- 11 Cell types supporting hepatitis C replication in vivo and in vitro -- 12 Understanding the natural history of hepatitis C -- 13 Animal models -- 14 Vaccine research -- Part III Experimental approaches -- 15 New systems to understand hepatitis C biology -- 16 New antiviral screening assays -- 17 Antiviral gene therapy -- Part IV Protocols and techniques.
18 Sample collection, preparation, and storage -- 19 Hepatitis C RNA in blood and tissue samples -- 20 Hepatitis C genotypes and quasispecies -- 21 Replication of hepatitis C in tissue culture -- 22 Enzyme activities of nonstructural protein 3 -- 23 Characterization of nonstructural protein 5B -- Part V Some outstanding questions and emerging areas for investigation -- 24 Outstanding issues -- 1. What are some of the implications of the physical heterogeneity of hepatitis C? -- 2. What is the significance of genetic heterogeneity within the 5' untranslated region? -- 3. What is the tissue range for hepatitis C? -- 4. What functions of nonstructural protein 5A are important for virus replication and hepatocarcinogenesis? -- 5. What determines the template specificity of hepatitis C encoded nonstructural protein 5B? -- 6. What happens when an asymptomatic individual is diagnosed as being infected by hepatitis C? -- 7. Should there be universal screening for hepatitis C RNA in all blood donors? -- 8. What happens if there is a suspected exposure to hepatitis C through needlestick or some other source? -- 9. Do different subtypes or quasispecies have different replicative abilities? -- 10. What are some of the outstanding issues that remain to be addressed to understand the natural history of infection? -- 11. Why is it difficult to assess the prognostice significance of immune responses in hepatitis C infection? -- 12. Can cytotoxic T lymphocytes clear hepatitis C effectively from liver? -- 13. Does hepatitis C play an important role in the pathogenesis of fulminant hepatitis? -- 14. What are the factors that lead to chronic infection? -- 15 . Does hepatitis C core antigen play a central role in hepatocarcinogenesis? -- 16. What are some of the putative steps whereby hepatitis C may transform hematopoietic cells?.
17. What are the mechanism(s) of antiviral activities mediated by interferon? -- 18. Who is recommended for treatment? -- 19. Why do in vitro tissue culture systems fail to support high levels of hepatitis C replication? -- 20. What are some of the problems that need to be addressed in th development of protective and/or therapeutic vaccines… -- 21. What are the goals and prospects for the future treatment of hepatitis C? -- 25 Prospects -- References -- Index.
Summary: An integrated, multidisciplinary account of the virus, its biology and clinical manifestations.
Holdings
Item type Current library Call number Status Date due Barcode Item holds
Ebrary Ebrary Afghanistan Available EBKAF0005684
Ebrary Ebrary Algeria Available
Ebrary Ebrary Cyprus Available
Ebrary Ebrary Egypt Available
Ebrary Ebrary Libya Available
Ebrary Ebrary Morocco Available
Ebrary Ebrary Nepal Available EBKNP0005684
Ebrary Ebrary Sudan Available
Ebrary Ebrary Tunisia Available
Total holds: 0

Cover -- Half-title -- Title -- Copyright -- Dedication -- Contents -- Preface -- Foreword -- Abbreviations -- Part I Basic principles -- 1 Background -- 1.1 The enigma of non-A, non-B hepatitis -- 1.2 The chimpanzee as a model of non-A non-B infection -- 1.3 Surrogate markers -- 1.4 The discovery of hepatitis C virus -- 1.5 The detection of viral antibodies -- 1.6 Testing for hepatitis C RNA -- 2 The virus -- 2.1 Physical characteristics of the virus -- 2.2 Genome structure and organization -- 2.3 The 5' untranslated region -- 2.4 Polyprotein processing and virus maturation -- 2.5 Gene expression and replication -- 3 Epidemiology and transmission -- 3.1 Seroprevalenc and burden of infection -- 3.2 Genotypes and subtypes -- 3.3 Prevention of infection -- 4 Natural history of infection -- 5 Pathogenesis of infection -- 5.1 Is hepatitis C cytopathic? -- 5.2 Immunopathology -- 5.3 Virus-specific B cell responses -- 5.4 Virus-specific T cell responses -- 6 Hepatitis C and hepatocellular carcinoma -- 6.1 Prevalenc and risk factors -- 6.2 Putative direct mechanisms of hepatitis C-mediated hepatocarcinogenesis -- 6.3 Subtypes of hepatitis C and hepatocellular carcinoma -- 6.4 Other mechanisms that may contribute to hepatocellular carcinoma associated with hepatitis C -- 7 Hepatitis C and autoimmune diseases -- 8 Clinical aspects of the disease -- 9 Current therapeutic approaches -- 10 Nonstructural protein 5A and interferon resistance -- Part II Recent advances -- 11 Cell types supporting hepatitis C replication in vivo and in vitro -- 12 Understanding the natural history of hepatitis C -- 13 Animal models -- 14 Vaccine research -- Part III Experimental approaches -- 15 New systems to understand hepatitis C biology -- 16 New antiviral screening assays -- 17 Antiviral gene therapy -- Part IV Protocols and techniques.

18 Sample collection, preparation, and storage -- 19 Hepatitis C RNA in blood and tissue samples -- 20 Hepatitis C genotypes and quasispecies -- 21 Replication of hepatitis C in tissue culture -- 22 Enzyme activities of nonstructural protein 3 -- 23 Characterization of nonstructural protein 5B -- Part V Some outstanding questions and emerging areas for investigation -- 24 Outstanding issues -- 1. What are some of the implications of the physical heterogeneity of hepatitis C? -- 2. What is the significance of genetic heterogeneity within the 5' untranslated region? -- 3. What is the tissue range for hepatitis C? -- 4. What functions of nonstructural protein 5A are important for virus replication and hepatocarcinogenesis? -- 5. What determines the template specificity of hepatitis C encoded nonstructural protein 5B? -- 6. What happens when an asymptomatic individual is diagnosed as being infected by hepatitis C? -- 7. Should there be universal screening for hepatitis C RNA in all blood donors? -- 8. What happens if there is a suspected exposure to hepatitis C through needlestick or some other source? -- 9. Do different subtypes or quasispecies have different replicative abilities? -- 10. What are some of the outstanding issues that remain to be addressed to understand the natural history of infection? -- 11. Why is it difficult to assess the prognostice significance of immune responses in hepatitis C infection? -- 12. Can cytotoxic T lymphocytes clear hepatitis C effectively from liver? -- 13. Does hepatitis C play an important role in the pathogenesis of fulminant hepatitis? -- 14. What are the factors that lead to chronic infection? -- 15 . Does hepatitis C core antigen play a central role in hepatocarcinogenesis? -- 16. What are some of the putative steps whereby hepatitis C may transform hematopoietic cells?.

17. What are the mechanism(s) of antiviral activities mediated by interferon? -- 18. Who is recommended for treatment? -- 19. Why do in vitro tissue culture systems fail to support high levels of hepatitis C replication? -- 20. What are some of the problems that need to be addressed in th development of protective and/or therapeutic vaccines… -- 21. What are the goals and prospects for the future treatment of hepatitis C? -- 25 Prospects -- References -- Index.

An integrated, multidisciplinary account of the virus, its biology and clinical manifestations.

Description based on publisher supplied metadata and other sources.

Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2019. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.

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