Genomics, Proteomics and Metabolomics in Nutraceuticals and Functional Foods.

By: Bagchi, Debasis
Contributor(s): Lau, Francis | Bagchi, Manashi | Bagchi, Manashi
Series: Hui: Food Science and Technology Ser: Publisher: New York : John Wiley & Sons, Incorporated, 2015Copyright date: ©2016Edition: 2nd edDescription: 1 online resource (1181 pages)Content type: text Media type: computer Carrier type: online resourceISBN: 9781118930434Subject(s): Nutrigenomics - methodsGenre/Form: Electronic books. Additional physical formats: Print version:: Genomics, Proteomics and Metabolomics in Nutraceuticals and Functional FoodsDDC classification: 613.2 LOC classification: QP144.F85 -- .G466 2015ebOnline resources: Click to View
Contents:
Intro -- Title Page -- Table of Contents -- Contributors -- Preface -- Part I: Introduction -- 1 Novel Omics Technologies in Food Nutrition -- 1.1 Introduction -- 1.2 Transcriptomics in Nutritional Research -- 1.3 Proteomics in Nutritional Research -- 1.4 Metabolomics in Nutritional Research -- 1.5 Systems Biology in Nutritional Research -- 1.6 Conclusions -- References -- 2 Seafood Authentication using Foodomics: Proteomics, Metabolomics, and Genomics -- 2.1 Introduction -- 2.2 Proteomic Approaches -- 2.3 Metabolomic Approaches -- 2.4 Genomic Approaches -- 2.5 Conclusions -- References -- 3 A Foodomics Approach Reveals Hypocholesterolemic Activity of Red Microalgae -- 3.1 Introduction -- 3.2 Marine Functional Foods and Supplements -- 3.3 Microalgae -- 3.4 Summary -- References -- Part II: Genomics -- 4 Gene-Diet Interaction and Weight Management -- 4.1 Introduction -- 4.2 Diet and Lifestyle Modifications in Weight Management -- 4.3 The Role of Genetic Factors in Determining Body Weight and Weight Loss -- 4.4 Gene-Diet Interactions on Body Weight and Risk of Obesity -- 4.5 Gene-Diet Interactions on Weight Loss in Randomized Clinical Trials -- 4.6 Gene-Diet Interactions on Weight Maintenance -- 4.7 Personalized Weight Management through Diet and Lifestyle Modifications -- 4.8 Summary and Concluding Remarks -- Acknowledgments -- References -- 5 NutrimiRomics: The Promise of a New Discipline in Nutrigenomics -- 5.1 Introduction -- 5.2 miRomics: A New Cornerstone -- 5.3 Nutrigenomics and miR -- References -- 6 Genomics as a Tool to Characterize Anti-inflammatory Nutraceuticals -- 6.1 Chronic Inflammation in Disease -- 6.2 Nutraceuticals in the Management of Chronic Inflammation -- 6.3 GeneChipTM as a Tool to Characterize the Anti-Inflammatory Properties of Nutraceuticals -- References -- 7 Nutrigenomics, Inflammaging, and Osteoarthritis: A Review.
7.1 Introduction -- 7.2 Osteoarthritis (OA) -- 7.3 Antioxidants and the Inflammatory Microenvironment -- 7.4 Inflammaging -- 7.5 Nutrigenomics -- 7.6 Muscle Inflammation in OA -- 7.7 Conclusions -- Acknowledgments, Competing Interests, and Disclosures -- References -- 8 Genetic Basis of Anti-Inflammatory Properties of Boswellia Extracts -- 8.1 Introduction -- 8.2 Boswellia serrata -- 8.3 Mechanism of Action -- 8.4 Development of 5-Loxin® (BE-30) -- 8.5 Gene Chip Probe Array Analysis -- 8.6 Proteomics -- 8.7 Molecular Basis of Anti-Inflammatory Properties of 5-LOXIN ® -- 8.8 In vivo Studies -- 8.9 Safety of 5-LOXIN ® -- 8.10 Clinical Efficacy of 5-LOXIN ® in the Management of Osteoarthritis -- 8.11 An Advanced 5-LOXIN®: Aflapin® -- 8.12 Conclusion -- References -- 9 Cancer Chemopreventive Phytochemicals Targeting NF-κB and Nrf2 Signaling Pathways -- 9.1 Introduction -- 9.2 Molecular-Based Cancer Chemoprevention -- 9.3 Nuclear Factor-Kappa B (NF-κB) -- 9.4 Nrf2 -- 9.5 Interplay/Crosstalk between Nrf2 and NF-κB Signaling Pathways -- 9.6 Conclusion -- Acknowledgment -- References -- 10 The Beneficial Health Effects of Fucoxanthin -- 10.1 Introduction -- 10.2 The Beneficial Health Effects of Carotenoids as Antioxidants -- 10.3 Anticancer Activity of Fucoxanthin -- 10.4 Anti-Obesity Effects of Fucoxanthin -- 10.5 Anti-Diabetic Effects of Fucoxanthin -- 10.6 Conclusion -- References -- 11 Nutrition, Genomics, and Human Health: A Complex Mechanism for Wellness -- 11.1 Introduction -- 11.2 Nutrition Sciences and Clinical Applications in Nutritional Genomics -- References -- 12 Application of Genomics and Bioinformatics Analysis in Exploratory Study of Functional Foods -- 12.1 Introduction -- 12.2 Analysis Tools -- 12.3 Interpretation Tools -- 12.4 Application Example of Kale (Brassica oleracea L. Var Acephala DC) -- 12.5 Conclusion -- References.
13 Omics Analysis and Databases for Plant Science -- 13.1 Introduction -- 13.2 NGS Technologies and Data Processing -- 13.3 De novo Plant Genome Assembly by NGS -- 13.4 Plant Genome Resequencing by NGS -- 13.5 Plant Transcriptome Analysis by NGS -- 13.6 Plant Genome and Annotation Databases -- 13.7 Plant Omics Databases -- 13.8 Conclusion -- References -- 14 Synergistic Plant Genomics and Molecular Breeding Approaches for Ensuring Food Security -- 14.1 Introduction -- 14.2 Plant Genomics, Transcriptomics, Proteomics, and Metabolomics Resources -- 14.3 Molecular Markers in Plant Genome Analysis -- 14.4 Identification of Functionally Relevant Molecular Tags Governing Agronomic Traits -- 14.5 Genomics-Assisted Crop Improvement -- References -- 15 Combinatorial Approaches Utilizing Nutraceuticals in Cancer Chemoprevention and Therapy -- 15.1 Introduction -- 15.2 Nutraceuticals -- 15.3 Nutraceuticals and Key Events in Cancer Development -- 15.4 Nutraceuticals in Combinatorial Therapy of Human Cancer: A Pledge of the Future -- 15.5 Curcumin: Potential for Combination Therapy -- 15.6 Resveratrol: Potential for Combination Therapy -- 15.7 Lycopene (a Carotenoid): Potential for Combinations Therapy -- 15.8 Soy Nutraceuticals: Potential for Combination Therapy -- 15.9 Tea Polyphenols Potential for Combinatorial Therapy -- 15.10 D-Limonene: Potential for Combination Therapy -- 15.11 Miscellaneous: Novel Nutraceuticals Formulation -- 15.12 Conclusion -- References -- 16 Nutrigenomic Approaches to Understanding the Transcriptional and Metabolic Responses of Phytochemicals to Diet-Induced Obesity and its Complications -- 16.1 Introduction -- 16.2 Nutrigenomics -- 16.3 Obesity and Cardiometabolic Syndrome -- 16.4 Anti-Obesity Action of Luteolin -- 16.5 Conclusion -- Acknowledgments -- References.
17 Going Beyond the Current Native Nutritional Food Through the Integration of the Omic Data in the Post-Genomic Era -- 17.1 Introduction -- 17.2 Starch and its Yield Improvement in Plants -- 17.3 An Extension of the (Resistant) Starch Yield Improvement Research on the Systems Biology Regime: Integration of the Omic Data from the Post-Genomic Technology -- References -- Part III: Proteomics -- 18 Proteomics and Nutrition Research -- 18.1 Introduction -- 18.2 Proteomics -- 18.3 Nutrition and Proteins -- 18.4 Nutritional Biomarkers -- 18.5 Nutritional Bioactives -- 18.6 Diet-Based Proteomics Application to Animal Products (Livestock Applications) -- 18.7 Proteomics and Food Safety -- 18.8 Conclusion -- 18.9 Significance -- Conflict of Interests -- References -- 19 Proteomics Analysis for the Functionality of Toona sinensis -- 19.1 Introduction -- 19.2 Toona sinensis -- 19.3 TSLs Regulate Functions of Testes/Spermatozoa -- 19.4 TSLs Regulate Liver Metabolism -- 19.5 TSL as a Novel Antioxidant -- 19.6 Possible Active Compounds in TSL Extracts -- 19.7 Conclusion -- References -- 20 Proteomic Approaches to Identify Novel Therapeutics and Nutraceuticals from Filamentous Fungi: Prospects and Challenges -- 20.1 Introduction -- 20.2 Mushroom Derived Immunomodulators and their Target Cells in the Immune System -- 20.3 Mushroom Derived Metabolites in Treating Cancer -- 20.4 Mushroom Derived Metabolites in Infectious Diseases -- 20.5 Fungal Enzymes as Therapeutics and Dietary Supplements -- 20.6 Identification and Characterization of Mushroom Derived Bioactive Therapeutics -- 20.7 Challenges in Intracellular Proteome Preparation -- 20.8 Challenges in Extracellular Proteome Preparation -- 20.9 New Generation MS Technologies to Track the Dynamic Proteome -- 20.10 Glycoproteomics: A New Arsenal in the Proteomic Toolbox -- 20.11 Glycoproteomics of Filamentous Fungi.
20.12 High-Throughput Approaches to Decipher Fungal Glycan Structures -- 20.13 Challenges in MS Studies of Glycans/Glycopeptides -- 20.14 Optimized MS Instrumentation for Glycan Analysis -- 20.15 Tandem Mass Spectrometry -- 20.16 Bioinformatics for Glycoproteomics: Hitting Databases with MS Peaks -- 20.17 Predicting Glycan Structures with Computational Tools -- 20.18 Concluding Remarks: The Road Ahead -- Acknowledgment -- References -- 21 Proteomics and Metaproteomics for Studying Probiotic Activity -- 21.1 Introduction -- 21.2 Molecular Mechanisms of Probiotic Action as Studied by Proteomics -- 21.3 Probiotics and Prebiotics -- 21.4 Investigation on Human Microbiota Dynamics by Proteomics -- 21.5 Concluding Remarks and Future Directions -- References -- 22 Proteomics Approach to Assess the Potency of Dietary Grape Seed Proanthocyanidins and Dimeric Procyanidin B2 -- 22.1 Chemoprotective Properties of GSPs -- 22.2 Proteomic Platform -- 22.3 Proteomics Analysis of the Actions of GSPs -- 22.4 Functional Confirmation of Proteins -- 22.5 Future Perspectives -- Acknowledgments -- References -- 23 Genomic and Proteomic Approaches to Lung Transplantation: Identifying Relevant Biomarkers to Improve Surgical Outcome -- 23.1 Introduction -- 23.2 Lung Transplantation -- 23.3 Challenges of Lung Transplantation -- 23.4 Inflammatory Biomarkers with Lung Rejection: Markers of Inflammation Signaling such as CAMs, Chemokines, and Cytokines and their Status with Transplants -- 23.5 Microarray Technology to Identify Transplant Rejection Biomarkers -- 23.6 Challenges and Future Directions -- References -- 24 Proteomics in Understanding the Molecular Basis of Phytochemicals for Health -- 24.1 Introduction -- 24.2 Proteomics in Phytochemical Research in Cancer Prevention -- 24.3 Perspectives -- 24.4 Proteomics in Phytochemical Research for Metabolic Diseases.
24.5 Proteomics for Neuroprotective Phytochemicals.
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Intro -- Title Page -- Table of Contents -- Contributors -- Preface -- Part I: Introduction -- 1 Novel Omics Technologies in Food Nutrition -- 1.1 Introduction -- 1.2 Transcriptomics in Nutritional Research -- 1.3 Proteomics in Nutritional Research -- 1.4 Metabolomics in Nutritional Research -- 1.5 Systems Biology in Nutritional Research -- 1.6 Conclusions -- References -- 2 Seafood Authentication using Foodomics: Proteomics, Metabolomics, and Genomics -- 2.1 Introduction -- 2.2 Proteomic Approaches -- 2.3 Metabolomic Approaches -- 2.4 Genomic Approaches -- 2.5 Conclusions -- References -- 3 A Foodomics Approach Reveals Hypocholesterolemic Activity of Red Microalgae -- 3.1 Introduction -- 3.2 Marine Functional Foods and Supplements -- 3.3 Microalgae -- 3.4 Summary -- References -- Part II: Genomics -- 4 Gene-Diet Interaction and Weight Management -- 4.1 Introduction -- 4.2 Diet and Lifestyle Modifications in Weight Management -- 4.3 The Role of Genetic Factors in Determining Body Weight and Weight Loss -- 4.4 Gene-Diet Interactions on Body Weight and Risk of Obesity -- 4.5 Gene-Diet Interactions on Weight Loss in Randomized Clinical Trials -- 4.6 Gene-Diet Interactions on Weight Maintenance -- 4.7 Personalized Weight Management through Diet and Lifestyle Modifications -- 4.8 Summary and Concluding Remarks -- Acknowledgments -- References -- 5 NutrimiRomics: The Promise of a New Discipline in Nutrigenomics -- 5.1 Introduction -- 5.2 miRomics: A New Cornerstone -- 5.3 Nutrigenomics and miR -- References -- 6 Genomics as a Tool to Characterize Anti-inflammatory Nutraceuticals -- 6.1 Chronic Inflammation in Disease -- 6.2 Nutraceuticals in the Management of Chronic Inflammation -- 6.3 GeneChipTM as a Tool to Characterize the Anti-Inflammatory Properties of Nutraceuticals -- References -- 7 Nutrigenomics, Inflammaging, and Osteoarthritis: A Review.

7.1 Introduction -- 7.2 Osteoarthritis (OA) -- 7.3 Antioxidants and the Inflammatory Microenvironment -- 7.4 Inflammaging -- 7.5 Nutrigenomics -- 7.6 Muscle Inflammation in OA -- 7.7 Conclusions -- Acknowledgments, Competing Interests, and Disclosures -- References -- 8 Genetic Basis of Anti-Inflammatory Properties of Boswellia Extracts -- 8.1 Introduction -- 8.2 Boswellia serrata -- 8.3 Mechanism of Action -- 8.4 Development of 5-Loxin® (BE-30) -- 8.5 Gene Chip Probe Array Analysis -- 8.6 Proteomics -- 8.7 Molecular Basis of Anti-Inflammatory Properties of 5-LOXIN ® -- 8.8 In vivo Studies -- 8.9 Safety of 5-LOXIN ® -- 8.10 Clinical Efficacy of 5-LOXIN ® in the Management of Osteoarthritis -- 8.11 An Advanced 5-LOXIN®: Aflapin® -- 8.12 Conclusion -- References -- 9 Cancer Chemopreventive Phytochemicals Targeting NF-κB and Nrf2 Signaling Pathways -- 9.1 Introduction -- 9.2 Molecular-Based Cancer Chemoprevention -- 9.3 Nuclear Factor-Kappa B (NF-κB) -- 9.4 Nrf2 -- 9.5 Interplay/Crosstalk between Nrf2 and NF-κB Signaling Pathways -- 9.6 Conclusion -- Acknowledgment -- References -- 10 The Beneficial Health Effects of Fucoxanthin -- 10.1 Introduction -- 10.2 The Beneficial Health Effects of Carotenoids as Antioxidants -- 10.3 Anticancer Activity of Fucoxanthin -- 10.4 Anti-Obesity Effects of Fucoxanthin -- 10.5 Anti-Diabetic Effects of Fucoxanthin -- 10.6 Conclusion -- References -- 11 Nutrition, Genomics, and Human Health: A Complex Mechanism for Wellness -- 11.1 Introduction -- 11.2 Nutrition Sciences and Clinical Applications in Nutritional Genomics -- References -- 12 Application of Genomics and Bioinformatics Analysis in Exploratory Study of Functional Foods -- 12.1 Introduction -- 12.2 Analysis Tools -- 12.3 Interpretation Tools -- 12.4 Application Example of Kale (Brassica oleracea L. Var Acephala DC) -- 12.5 Conclusion -- References.

13 Omics Analysis and Databases for Plant Science -- 13.1 Introduction -- 13.2 NGS Technologies and Data Processing -- 13.3 De novo Plant Genome Assembly by NGS -- 13.4 Plant Genome Resequencing by NGS -- 13.5 Plant Transcriptome Analysis by NGS -- 13.6 Plant Genome and Annotation Databases -- 13.7 Plant Omics Databases -- 13.8 Conclusion -- References -- 14 Synergistic Plant Genomics and Molecular Breeding Approaches for Ensuring Food Security -- 14.1 Introduction -- 14.2 Plant Genomics, Transcriptomics, Proteomics, and Metabolomics Resources -- 14.3 Molecular Markers in Plant Genome Analysis -- 14.4 Identification of Functionally Relevant Molecular Tags Governing Agronomic Traits -- 14.5 Genomics-Assisted Crop Improvement -- References -- 15 Combinatorial Approaches Utilizing Nutraceuticals in Cancer Chemoprevention and Therapy -- 15.1 Introduction -- 15.2 Nutraceuticals -- 15.3 Nutraceuticals and Key Events in Cancer Development -- 15.4 Nutraceuticals in Combinatorial Therapy of Human Cancer: A Pledge of the Future -- 15.5 Curcumin: Potential for Combination Therapy -- 15.6 Resveratrol: Potential for Combination Therapy -- 15.7 Lycopene (a Carotenoid): Potential for Combinations Therapy -- 15.8 Soy Nutraceuticals: Potential for Combination Therapy -- 15.9 Tea Polyphenols Potential for Combinatorial Therapy -- 15.10 D-Limonene: Potential for Combination Therapy -- 15.11 Miscellaneous: Novel Nutraceuticals Formulation -- 15.12 Conclusion -- References -- 16 Nutrigenomic Approaches to Understanding the Transcriptional and Metabolic Responses of Phytochemicals to Diet-Induced Obesity and its Complications -- 16.1 Introduction -- 16.2 Nutrigenomics -- 16.3 Obesity and Cardiometabolic Syndrome -- 16.4 Anti-Obesity Action of Luteolin -- 16.5 Conclusion -- Acknowledgments -- References.

17 Going Beyond the Current Native Nutritional Food Through the Integration of the Omic Data in the Post-Genomic Era -- 17.1 Introduction -- 17.2 Starch and its Yield Improvement in Plants -- 17.3 An Extension of the (Resistant) Starch Yield Improvement Research on the Systems Biology Regime: Integration of the Omic Data from the Post-Genomic Technology -- References -- Part III: Proteomics -- 18 Proteomics and Nutrition Research -- 18.1 Introduction -- 18.2 Proteomics -- 18.3 Nutrition and Proteins -- 18.4 Nutritional Biomarkers -- 18.5 Nutritional Bioactives -- 18.6 Diet-Based Proteomics Application to Animal Products (Livestock Applications) -- 18.7 Proteomics and Food Safety -- 18.8 Conclusion -- 18.9 Significance -- Conflict of Interests -- References -- 19 Proteomics Analysis for the Functionality of Toona sinensis -- 19.1 Introduction -- 19.2 Toona sinensis -- 19.3 TSLs Regulate Functions of Testes/Spermatozoa -- 19.4 TSLs Regulate Liver Metabolism -- 19.5 TSL as a Novel Antioxidant -- 19.6 Possible Active Compounds in TSL Extracts -- 19.7 Conclusion -- References -- 20 Proteomic Approaches to Identify Novel Therapeutics and Nutraceuticals from Filamentous Fungi: Prospects and Challenges -- 20.1 Introduction -- 20.2 Mushroom Derived Immunomodulators and their Target Cells in the Immune System -- 20.3 Mushroom Derived Metabolites in Treating Cancer -- 20.4 Mushroom Derived Metabolites in Infectious Diseases -- 20.5 Fungal Enzymes as Therapeutics and Dietary Supplements -- 20.6 Identification and Characterization of Mushroom Derived Bioactive Therapeutics -- 20.7 Challenges in Intracellular Proteome Preparation -- 20.8 Challenges in Extracellular Proteome Preparation -- 20.9 New Generation MS Technologies to Track the Dynamic Proteome -- 20.10 Glycoproteomics: A New Arsenal in the Proteomic Toolbox -- 20.11 Glycoproteomics of Filamentous Fungi.

20.12 High-Throughput Approaches to Decipher Fungal Glycan Structures -- 20.13 Challenges in MS Studies of Glycans/Glycopeptides -- 20.14 Optimized MS Instrumentation for Glycan Analysis -- 20.15 Tandem Mass Spectrometry -- 20.16 Bioinformatics for Glycoproteomics: Hitting Databases with MS Peaks -- 20.17 Predicting Glycan Structures with Computational Tools -- 20.18 Concluding Remarks: The Road Ahead -- Acknowledgment -- References -- 21 Proteomics and Metaproteomics for Studying Probiotic Activity -- 21.1 Introduction -- 21.2 Molecular Mechanisms of Probiotic Action as Studied by Proteomics -- 21.3 Probiotics and Prebiotics -- 21.4 Investigation on Human Microbiota Dynamics by Proteomics -- 21.5 Concluding Remarks and Future Directions -- References -- 22 Proteomics Approach to Assess the Potency of Dietary Grape Seed Proanthocyanidins and Dimeric Procyanidin B2 -- 22.1 Chemoprotective Properties of GSPs -- 22.2 Proteomic Platform -- 22.3 Proteomics Analysis of the Actions of GSPs -- 22.4 Functional Confirmation of Proteins -- 22.5 Future Perspectives -- Acknowledgments -- References -- 23 Genomic and Proteomic Approaches to Lung Transplantation: Identifying Relevant Biomarkers to Improve Surgical Outcome -- 23.1 Introduction -- 23.2 Lung Transplantation -- 23.3 Challenges of Lung Transplantation -- 23.4 Inflammatory Biomarkers with Lung Rejection: Markers of Inflammation Signaling such as CAMs, Chemokines, and Cytokines and their Status with Transplants -- 23.5 Microarray Technology to Identify Transplant Rejection Biomarkers -- 23.6 Challenges and Future Directions -- References -- 24 Proteomics in Understanding the Molecular Basis of Phytochemicals for Health -- 24.1 Introduction -- 24.2 Proteomics in Phytochemical Research in Cancer Prevention -- 24.3 Perspectives -- 24.4 Proteomics in Phytochemical Research for Metabolic Diseases.

24.5 Proteomics for Neuroprotective Phytochemicals.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2019. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.

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