Acute Rejection : Risk Factors, Management and Complications.

By: Kobayashi, TakumiContributor(s): Arai, RikuSeries: Immunology and Immune System DisordersPublisher: Hauppauge : Nova Science Publishers, Incorporated, 2012Copyright date: ©2012Description: 1 online resource (211 pages)Content type: text Media type: computer Carrier type: online resourceISBN: 9781619423510Subject(s): Graft rejectionGenre/Form: Electronic books. Additional physical formats: Print version:: Acute Rejection : Risk Factors, Management and ComplicationsLOC classification: QR188.8.A28 2012Online resources: Click to View
Contents:
Intro -- ACUTE REJECTION: RISK FACTORS, MANAGEMENT AND COMPLICATIONS -- ACUTE REJECTION: RISK FACTORS, MANAGEMENT AND COMPLICATIONS -- Library of Congress Cataloging-in-Publication Data -- Contents -- Preface -- Chapter 1: HLA and Non-HLA Genes Polymorphisms: Susceptibility and Severity in Tunisian Patients with Rheumatoid Arthritis -- Abstract -- 1. Introduction -- 2. Evaluation of Genetic Predisposition to RA -- 2.1. Prevalence of RA -- 2.2. Familial Clustering Studies -- 2.3. Twins Studies -- 3. Identification of Candidate Genes -- 3.1. Linkage Studies -- 3.2. Candidate Gene Association Studies -- 4. Results of Linkage Studies in RA -- 5. HLA Association With RA -- 6. Non HLA Candidate Genes Case-control Studies -- 6.1. Protein Tyrosine Phosphatase Non-Receptor, Type 22 (PTPN22) -- 6.2. Tumor Necrosis Factor Receptor Type 2 (TNF-R2) -- 6.3. Peptidyl Arginine Deiminase 4 (PADI 4) -- 6.4. Fc γ Receptor IIIa (FcγRIIIa) -- 6.5. Interleukin 1 Receptor Antagonist (IL-1Ra) -- 6.6. Cytotoxic T Lymphocyte-Associated Antigen-4 (CTLA-4) -- 6.7. Apo-1/Fas (CD95) -- 6.8. Adhesion Molecules -- 7. Patients and Methods -- 7.1. Patients and Controls -- 7.2. Methods -- 7.3. Statistical Methods -- 8. Results -- 8.1. HLA Typing -- a/ DRB1 Genotyping -- b/ DRB1*04 Sub-typing -- 8.2. PTPN22 Genotyping -- 8.3. CTLA-4 Genotyping -- 8.4. Apo-1/Fas Genotyping -- 8.5. FcγR Genotyping -- 8.6. Adhesion Molecules Genotyping -- 8.7. IL1 Family Polymorphisms Genotyping -- a/ IL1α (C/T -889) -- b/ IL1Ra (Intron 2) -- c/ IL1β C/T -511 and C/T +3954 -- 9. Discussion -- Conclusion -- Acknowledgment -- References -- Chapter 2: Mechanisms, Management and Consequences of Acute Cellular and Antibody Mediated Rejection in Solid Organ and Reconstructive Transplantation -- Abstract -- 1. Acute Rejection -- 2. Kidney Transplantation -- 2.1 The Banff Classification.
2.2 Acute Antibody-Mediated Rejection in Kidney Transplantation -- 2.3 Acute T-Cell-Mediated Rejection in Kidney Transplantation -- 2.3.1. Steps in TCMR - 3 Signals [12] -- 3. Pancreas Transplantation -- 3.1 The Banff Classification -- 3.2 Acute Antibody-Mediated Rejection in Pancreas Transplantation -- 3.3 Acute T-Cell-Mediated Rejection in Pancreas Transplantation -- 4. Liver Transplantation -- 4.1 Banff Schema for Grading of Liver Allograft Rejection -- 4.2 Acute Antibody-Mediated Rejection in Liver Transplantation -- 4.3 Acute T-Cell-Mediated Rejection in Liver Transplantation -- 5. Intestinal and Multivisceral Transplantation -- 5.2 Acute Antibody-Mediated Rejection in Intestinal Transplantation -- 5.3 Acute T-Cell-Mediated Rejection in Intestinal Transplantation -- 6. Vascularized Composite Allotransplantation -- 6.1 Banff Classification of Skin-Containing Composite Tissue Allografts -- 6.2. Acute Rejection in VCA -- 6.2.1. Acute Antibody-Mediated Rejection in VCA -- 6.2.2. Acute T Cell Mediated Rejection in VCA -- Conclusion -- Abbreviations -- References -- Chapter 3: Donor Specific Antibody (DSA) Mediated Humoral Rejection and Biological Implications of B Cells in Human Solid Organ Transplantation -- Abstract -- Introduction -- Human Leukocyte Antigens in Acute Rejection -- Characterization of the Immunological Risk Prior to Transplantation -- Non-HLA Antigens in Acute Rejection -- B Cells, Antibody Response and Rejection -- Treatment of Antibody-Mediated Rejection -- Accommodation Phenomenon to Prevent Rejection -- Processes Implicated on Accommodation -- Biological Implication of Accommodation in Transplantation -- Conclusion -- Acknowledgment -- References -- Chapter 4: Acute Cellular Rejection: Diagnosis and Immune Mechanisms -- Abstract -- Introduction -- The Acute Rejection Diagnostic.
Immune Mechanisms Involved in Cellular Mediated Injury -- New Tolls for Diagnosing Acute Cellular Rejection -- Evaluation of Lymphocyte Functionality and Reactivity -- ImmuKnow® (Ciclex, Columbia, MD) -- ELISPOT -- Detection of Molecules Related to Immune Activation -- Soluble CD30 -- Detection of Gene Transcripts -- Transcripts in Blood -- Transcripts in Urine -- Gene Expression Profiling -- MicroRNAs -- Proteomics -- Conclusion -- References -- Chapter 5: Presentation, Diagnosis and Treatment of Acute Rejection -- 1Department of Pharmacy Practice and Administration, School of Pharmacy, University of Missouri-Kansas City, Missouri, US -- 2Department of Internal Medicine, Washington University School of Medicine in St. Louis, St. Louis, Missouri, US -- Abstract -- Introduction -- Risk Factors -- Pathophysiology -- Presentation of Acute Rejection -- Diagnosis of Acute Rejection -- Management -- Complications -- Conclusion -- References -- Chapter 6: Novel Nucleic Acid Drugs for Prevention of Acute Cardiac Rejection* -- 1Department of Advanced Clinical Science and Therapeutics, University of Tokyo, Tokyo, Japan -- 2Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan -- 3Department of Clinical Gene Therapy, Osaka University, Osaka, Japan -- 4Department of Cardiovascular Medicine, University of Tokyo, Tokyo, Japan -- Abstract -- Introduction -- NF-(B DECOY ODN -- STAT-1 DECOY ODN -- AP-1 DECOY ODN -- Conclusion -- References -- Chapter 7: Study of Proliferation Response of the HLA-DQB1*0302 Molecule Associated to Acute Rejection Development in Liver Transplant and Soluble HLA Class I Depletion* -- Immunology Service, University Hospital Virgen Arrixaca, -- Murcia 30120, Spain -- Abstract -- Introduction -- Materials and Methods -- HLA Typing -- Serum sHLA Depletion -- EBV-Transformation of Stimulator Cells.
Mixed Lymphocyte Cultures -- Statistical Analysis -- Results -- Discussion -- Conclusion -- Acknowledgment -- References -- Index.
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Intro -- ACUTE REJECTION: RISK FACTORS, MANAGEMENT AND COMPLICATIONS -- ACUTE REJECTION: RISK FACTORS, MANAGEMENT AND COMPLICATIONS -- Library of Congress Cataloging-in-Publication Data -- Contents -- Preface -- Chapter 1: HLA and Non-HLA Genes Polymorphisms: Susceptibility and Severity in Tunisian Patients with Rheumatoid Arthritis -- Abstract -- 1. Introduction -- 2. Evaluation of Genetic Predisposition to RA -- 2.1. Prevalence of RA -- 2.2. Familial Clustering Studies -- 2.3. Twins Studies -- 3. Identification of Candidate Genes -- 3.1. Linkage Studies -- 3.2. Candidate Gene Association Studies -- 4. Results of Linkage Studies in RA -- 5. HLA Association With RA -- 6. Non HLA Candidate Genes Case-control Studies -- 6.1. Protein Tyrosine Phosphatase Non-Receptor, Type 22 (PTPN22) -- 6.2. Tumor Necrosis Factor Receptor Type 2 (TNF-R2) -- 6.3. Peptidyl Arginine Deiminase 4 (PADI 4) -- 6.4. Fc γ Receptor IIIa (FcγRIIIa) -- 6.5. Interleukin 1 Receptor Antagonist (IL-1Ra) -- 6.6. Cytotoxic T Lymphocyte-Associated Antigen-4 (CTLA-4) -- 6.7. Apo-1/Fas (CD95) -- 6.8. Adhesion Molecules -- 7. Patients and Methods -- 7.1. Patients and Controls -- 7.2. Methods -- 7.3. Statistical Methods -- 8. Results -- 8.1. HLA Typing -- a/ DRB1 Genotyping -- b/ DRB1*04 Sub-typing -- 8.2. PTPN22 Genotyping -- 8.3. CTLA-4 Genotyping -- 8.4. Apo-1/Fas Genotyping -- 8.5. FcγR Genotyping -- 8.6. Adhesion Molecules Genotyping -- 8.7. IL1 Family Polymorphisms Genotyping -- a/ IL1α (C/T -889) -- b/ IL1Ra (Intron 2) -- c/ IL1β C/T -511 and C/T +3954 -- 9. Discussion -- Conclusion -- Acknowledgment -- References -- Chapter 2: Mechanisms, Management and Consequences of Acute Cellular and Antibody Mediated Rejection in Solid Organ and Reconstructive Transplantation -- Abstract -- 1. Acute Rejection -- 2. Kidney Transplantation -- 2.1 The Banff Classification.

2.2 Acute Antibody-Mediated Rejection in Kidney Transplantation -- 2.3 Acute T-Cell-Mediated Rejection in Kidney Transplantation -- 2.3.1. Steps in TCMR - 3 Signals [12] -- 3. Pancreas Transplantation -- 3.1 The Banff Classification -- 3.2 Acute Antibody-Mediated Rejection in Pancreas Transplantation -- 3.3 Acute T-Cell-Mediated Rejection in Pancreas Transplantation -- 4. Liver Transplantation -- 4.1 Banff Schema for Grading of Liver Allograft Rejection -- 4.2 Acute Antibody-Mediated Rejection in Liver Transplantation -- 4.3 Acute T-Cell-Mediated Rejection in Liver Transplantation -- 5. Intestinal and Multivisceral Transplantation -- 5.2 Acute Antibody-Mediated Rejection in Intestinal Transplantation -- 5.3 Acute T-Cell-Mediated Rejection in Intestinal Transplantation -- 6. Vascularized Composite Allotransplantation -- 6.1 Banff Classification of Skin-Containing Composite Tissue Allografts -- 6.2. Acute Rejection in VCA -- 6.2.1. Acute Antibody-Mediated Rejection in VCA -- 6.2.2. Acute T Cell Mediated Rejection in VCA -- Conclusion -- Abbreviations -- References -- Chapter 3: Donor Specific Antibody (DSA) Mediated Humoral Rejection and Biological Implications of B Cells in Human Solid Organ Transplantation -- Abstract -- Introduction -- Human Leukocyte Antigens in Acute Rejection -- Characterization of the Immunological Risk Prior to Transplantation -- Non-HLA Antigens in Acute Rejection -- B Cells, Antibody Response and Rejection -- Treatment of Antibody-Mediated Rejection -- Accommodation Phenomenon to Prevent Rejection -- Processes Implicated on Accommodation -- Biological Implication of Accommodation in Transplantation -- Conclusion -- Acknowledgment -- References -- Chapter 4: Acute Cellular Rejection: Diagnosis and Immune Mechanisms -- Abstract -- Introduction -- The Acute Rejection Diagnostic.

Immune Mechanisms Involved in Cellular Mediated Injury -- New Tolls for Diagnosing Acute Cellular Rejection -- Evaluation of Lymphocyte Functionality and Reactivity -- ImmuKnow® (Ciclex, Columbia, MD) -- ELISPOT -- Detection of Molecules Related to Immune Activation -- Soluble CD30 -- Detection of Gene Transcripts -- Transcripts in Blood -- Transcripts in Urine -- Gene Expression Profiling -- MicroRNAs -- Proteomics -- Conclusion -- References -- Chapter 5: Presentation, Diagnosis and Treatment of Acute Rejection -- 1Department of Pharmacy Practice and Administration, School of Pharmacy, University of Missouri-Kansas City, Missouri, US -- 2Department of Internal Medicine, Washington University School of Medicine in St. Louis, St. Louis, Missouri, US -- Abstract -- Introduction -- Risk Factors -- Pathophysiology -- Presentation of Acute Rejection -- Diagnosis of Acute Rejection -- Management -- Complications -- Conclusion -- References -- Chapter 6: Novel Nucleic Acid Drugs for Prevention of Acute Cardiac Rejection* -- 1Department of Advanced Clinical Science and Therapeutics, University of Tokyo, Tokyo, Japan -- 2Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan -- 3Department of Clinical Gene Therapy, Osaka University, Osaka, Japan -- 4Department of Cardiovascular Medicine, University of Tokyo, Tokyo, Japan -- Abstract -- Introduction -- NF-(B DECOY ODN -- STAT-1 DECOY ODN -- AP-1 DECOY ODN -- Conclusion -- References -- Chapter 7: Study of Proliferation Response of the HLA-DQB1*0302 Molecule Associated to Acute Rejection Development in Liver Transplant and Soluble HLA Class I Depletion* -- Immunology Service, University Hospital Virgen Arrixaca, -- Murcia 30120, Spain -- Abstract -- Introduction -- Materials and Methods -- HLA Typing -- Serum sHLA Depletion -- EBV-Transformation of Stimulator Cells.

Mixed Lymphocyte Cultures -- Statistical Analysis -- Results -- Discussion -- Conclusion -- Acknowledgment -- References -- Index.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2019. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.

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