Chemical Modulators of Protein Misfolding and Neurodegenerative Disease.

By: Seneci, PierfaustoPublisher: Saint Louis : Elsevier Science & Technology, 2015Copyright date: ©2015Description: 1 online resource (260 pages)Content type: text Media type: computer Carrier type: online resourceISBN: 9780128019597Subject(s): Nervous system -- DegenerationGenre/Form: Electronic books. Additional physical formats: Print version:: Chemical Modulators of Protein Misfolding and Neurodegenerative DiseaseDDC classification: 572.6 LOC classification: RC365 -- .S464 2015ebOnline resources: Click to View
Contents:
Cover -- Title Page -- Copyright Page -- Dedication -- Contents -- Abbreviations -- Chapter 1 - Chemical Modulators of Protein Misfolding, Neurodegeneration and Tau -- 1.1 - Tau-targeted compounds -- 1.1.1 - Tau Kinase Inhibitors -- 1.1.2 - Tau O-GlcNAcylation Enhancers -- 1.1.3 - Microtubule (MT)-binding Compounds -- 1.2 - Ab-targeted compounds -- 1.2.1 - γ-Secretase Inhibitors (GSIs) and Modulators (GSMs) -- 1.2.2 - Multi-targeted Neuroprotective and Proneurogenic Compounds -- References -- Chapter 2 - Targeting the Protein Quality Control (PQC) Machinery -- 2.1 - Molecular chaperones, pqc, and neurodegeneration -- 2.2 - Hsp27 -- 2.3 - Hsp70 -- 2.3.1 - Hsp70 Inhibitors -- 2.3.2 - Hsp70-BAG-1 Inhibitors -- 2.4 - Hsp90 -- 2.4.1 - Hsp90 Inhibitors -- 2.4.2 - Hsp90-Co-chaperone Complexes: Direct Inhibition -- 2.4.3 - Hsp90-Co-chaperone Complexes: Indirect Inhibition -- 2.5 - Recap -- References -- Chapter 3 - Targeting Proteasomal Degradation of Soluble, Misfolded Proteins -- 3.1 - UPS-mediated degradation of misfolded proteins -- 3.2 - CHIP -- 3.3 - USP14 -- 3.4 - Recap -- References -- Chapter 4 - Targeting Unselective Autophagy of Cellular Aggregates -- 4.1 - Macroautophagy mediated degradation of protein aggregates -- 4.2 - mTORC1 -- 4.3 - Small molecule enhancers of rapamycin (sMERs) -- 4.4 - Recap -- References -- Chapter 5 - Targeting Selective Autophagy of Insoluble Protein Aggregates -- 5.1 - Aggrephagy-mediated degradation of protein aggregates -- 5.2 - p62 -- 5.3 - HDAC6 -- 5.4 - Recap -- References -- Chapter 6 - Targeting Assembly and Disassembly of Protein Aggregates -- 6.1 - Disordered protein aggregates and ordered amyloid fibrils -- 6.2 - Interfering with (neuro)toxic tau species in the aggregation process -- 6.3 - Hsp110-driven disaggregation -- 6.4 - Recap -- References -- Index.
Summary: This book is a neurochemistry-based companion for Protein Misfolding and Neurodegenerative Diseases: Molecular Targets, an Elsevier title by the same author publishing in December 2014. While the first book focuses on biology and molecular targets, this companion book describes how these targets are regulated by small molecules and disease-modifying compounds. The book begins with a brief introduction to how key proteins become dysfunctional, and each subsequent chapter describes major disease mechanisms in Alzheimer's and other tauopathies. Properties and development status of these molecular targets and disease mechanisms are thoroughly described, as are small molecule effectors of autophagy and dis-aggregating agents. Written to provide comprehensive coverage of neurodegenerative disease-modifying compounds Provides discipline-specific chapters that cover medicinal chemistry and clinical applications Provides an overview of more than 200 chemical classes and lead compounds, acting on selected molecular targets that are of relevance to any neurodegenerative disorder Coverage of misfolding diseases, chaperone proteins, ubiquitination and autophagy/oncology makes this book suitable for structural neurochemists, chemists, biologists, non-CNS scientists, and scientists interested in drug discovery.
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Cover -- Title Page -- Copyright Page -- Dedication -- Contents -- Abbreviations -- Chapter 1 - Chemical Modulators of Protein Misfolding, Neurodegeneration and Tau -- 1.1 - Tau-targeted compounds -- 1.1.1 - Tau Kinase Inhibitors -- 1.1.2 - Tau O-GlcNAcylation Enhancers -- 1.1.3 - Microtubule (MT)-binding Compounds -- 1.2 - Ab-targeted compounds -- 1.2.1 - γ-Secretase Inhibitors (GSIs) and Modulators (GSMs) -- 1.2.2 - Multi-targeted Neuroprotective and Proneurogenic Compounds -- References -- Chapter 2 - Targeting the Protein Quality Control (PQC) Machinery -- 2.1 - Molecular chaperones, pqc, and neurodegeneration -- 2.2 - Hsp27 -- 2.3 - Hsp70 -- 2.3.1 - Hsp70 Inhibitors -- 2.3.2 - Hsp70-BAG-1 Inhibitors -- 2.4 - Hsp90 -- 2.4.1 - Hsp90 Inhibitors -- 2.4.2 - Hsp90-Co-chaperone Complexes: Direct Inhibition -- 2.4.3 - Hsp90-Co-chaperone Complexes: Indirect Inhibition -- 2.5 - Recap -- References -- Chapter 3 - Targeting Proteasomal Degradation of Soluble, Misfolded Proteins -- 3.1 - UPS-mediated degradation of misfolded proteins -- 3.2 - CHIP -- 3.3 - USP14 -- 3.4 - Recap -- References -- Chapter 4 - Targeting Unselective Autophagy of Cellular Aggregates -- 4.1 - Macroautophagy mediated degradation of protein aggregates -- 4.2 - mTORC1 -- 4.3 - Small molecule enhancers of rapamycin (sMERs) -- 4.4 - Recap -- References -- Chapter 5 - Targeting Selective Autophagy of Insoluble Protein Aggregates -- 5.1 - Aggrephagy-mediated degradation of protein aggregates -- 5.2 - p62 -- 5.3 - HDAC6 -- 5.4 - Recap -- References -- Chapter 6 - Targeting Assembly and Disassembly of Protein Aggregates -- 6.1 - Disordered protein aggregates and ordered amyloid fibrils -- 6.2 - Interfering with (neuro)toxic tau species in the aggregation process -- 6.3 - Hsp110-driven disaggregation -- 6.4 - Recap -- References -- Index.

This book is a neurochemistry-based companion for Protein Misfolding and Neurodegenerative Diseases: Molecular Targets, an Elsevier title by the same author publishing in December 2014. While the first book focuses on biology and molecular targets, this companion book describes how these targets are regulated by small molecules and disease-modifying compounds. The book begins with a brief introduction to how key proteins become dysfunctional, and each subsequent chapter describes major disease mechanisms in Alzheimer's and other tauopathies. Properties and development status of these molecular targets and disease mechanisms are thoroughly described, as are small molecule effectors of autophagy and dis-aggregating agents. Written to provide comprehensive coverage of neurodegenerative disease-modifying compounds Provides discipline-specific chapters that cover medicinal chemistry and clinical applications Provides an overview of more than 200 chemical classes and lead compounds, acting on selected molecular targets that are of relevance to any neurodegenerative disorder Coverage of misfolding diseases, chaperone proteins, ubiquitination and autophagy/oncology makes this book suitable for structural neurochemists, chemists, biologists, non-CNS scientists, and scientists interested in drug discovery.

Description based on publisher supplied metadata and other sources.

Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2019. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.

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