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Matrix Metalloproteinase Biology.

By: Contributor(s): Publisher: New York : John Wiley & Sons, Incorporated, 2015Copyright date: ©2015Edition: 1st edDescription: 1 online resource (294 pages)Content type:
  • text
Media type:
  • computer
Carrier type:
  • online resource
ISBN:
  • 9781118772294
Subject(s): Genre/Form: Additional physical formats: Print version:: Matrix Metalloproteinase BiologyDDC classification:
  • 572/.696
LOC classification:
  • QP552 .M47
Online resources:
Contents:
Intro -- Title Page -- Copyright -- Table of Contents -- List of Contributors -- Chapter 1: Matrix Metalloproteinases: From Structure to Function -- 1.1 Introduction -- 1.2 Structures of MMPs -- 1.3 Overview of MMP substrate specificity -- 1.4 Selective mechanisms of action -- Acknowledgments -- References -- Chapter 2: Dynamics and Mechanism of Substrate Recognition by Matrix Metalloproteases -- 2.1 Introduction -- 2.2 Conformational flexibility of MMPs is inexorably linked to collagen proteolysis -- 2.3 Dynamics of MMP-2 and MMP-9 interaction with gelatin -- 2.4 Surface diffusion: a common mechanism for substrate interaction adapted by MMP-2 and MMP-9 -- 2.5 Dynamics of MMP interaction with collagen fibrils -- 2.6 Mechanism of interaction of MMP-1, MMP-2, MMP-9, and MMP-14 with collagen substrate involves surface diffusion -- 2.7 Mechanism of MMP-1 diffusion on native collagen fibrils -- 2.8 Triple helical collagen cleavage-diffusion coupling -- 2.9 Conclusions -- References -- Chapter 3: Matrix Metalloproteinases: From Structure to Function -- 3.1 Introduction -- 3.2 Classification and structural features -- 3.3 Catalytic mechanism -- 3.4 Intra- and inter-domain flexibility -- 3.5 Elastin and collagen degradation -- References -- Chapter 4: Metzincin Modulators -- 4.1 Inhibitors -- Summary and future directions -- References -- Chapter 5: Therapeutics Targeting Matrix Metalloproteinases -- 5.1 Introduction -- 5.2 Peptidomimetic MMP inhibitors -- 5.3 Structure-based MMPI drug design -- 5.4 Mechanism-based MMPI design -- 5.5 Allosteric MMPI design -- 5.6 Macromolecular MMP inhibitors -- 5.7 Chemically-Modified tetracyclines -- 5.8 Alternative approaches -- 5.9 MMPs as anti-targets -- 5.10 Conclusions -- References -- Chapter 6: Matrix Metalloproteinase Modification of Extracellular Matrix-Mediated Signaling -- 6.1 Introduction.
6.2 The extracellular matrix as a source for signaling ligands -- 6.3 ECM and mechanosensory signal transduction -- 6.4 Matrix remodeling and modification of mechano-sensory signaling -- 6.5 Conclusions and future directions -- References -- Chapter 7: Meprin and ADAM Metalloproteases: Two Sides of the Same Coin? -- 7.1 Introduction -- 7.2 Meprin metalloproteases -- 7.3 Structure of meprin α and meprin β -- 7.4 Proteomics for the identification of meprin substrates -- 7.5 Meprins in health and disease -- 7.6 Proteolytic back-and-forth of meprins and ADAMs -- 7.7 Collagen fibril formation -- 7.8 Angiogenesis and cancer -- 7.9 Inflammation -- 7.10 ADAM Proteases -- 7.11 The ADAM family of proteases -- 7.12 Orchestration of different pathways by ADAM17 -- 7.13 Regulation of ADAM17 activity -- 7.14 Role of ADAM17 in vivo -- 7.15 Role of ADAM17 in humans -- References -- Chapter 8: Subtracting Matrix out of the Equation: New Key Roles of Matrix Metalloproteinases in Innate Immunity and Disease -- 8.1 The tale of a Frog's tail -- 8.2 The MMP family -- 8.3 Making the cut as immune regulators -- 8.4 Enter the "omics" era: genomics, proteomics and degradomics -- 8.5 ECM versus Non-ECM MMP substrates -- 8.6 Moonlighting protein substrates: intracellular proteins cleaved outside the cell -- 8.7 Intracellular protein substrates cleaved inside the cell by MMPs -- 8.8 Non-proteolytic roles of MMPs: missed in the myth? -- 8.9 The fairy TAIL of a frog Has an unexpected ending -- Acknowledgements -- References -- Chapter 9: MMPs: From Genomics to Degradomics -- 9.1 Introduction -- 9.2 Degradomics - an overview -- 9.3 Conclusions -- Acknowledgments -- References -- Chapter 10: MMPs in Biology and Medicine -- 10.1 Introduction -- 10.2 Functional roles of MMPs and ADAMs -- 10.3 MMPs as diagnostic and prognostic biomarkers of cancer.
10.4 MMPs/ADAMs as diagnostic and prognostic biomarkers for non-neoplastic diseases -- 10.5 MMPs as biomarkers of therapeutic efficacy -- 10.6 MMP-specific molecular imaging for noninvasive disease detection -- 10.7 Conclusions -- Acknowledgments -- References -- Index -- End User License Agreement.
Summary: Discussing recent advances in the field of matrix metalloproteinase (MMP) research from a multidisciplinary perspective, Matrix Metalloproteinase Biologyis a collection of chapters written by leaders in the field of MMPs.  The book focuses on the challenges of understanding the mechanisms substrate degradation by MMPs, as well as how these enzymes are able to degrade large, highly ordered substrates such as collagen. All topics addressed are considered in relation to disease progression including roles in cancer metastasis, rheumatoid arthritis and other inflammatory diseases. The text first provides an overview of MMPs, focusing on the history, the development and failures of small molecule inhibitors in clinical trials, and work with TIMPS, the endogenous inhibitors of MMPs. These introductory chapters establish the foundation for later discussion of the recent progress on the design of different types of inhibitors, including novel antibody based therapeutics. The following section emphasizes research using novel methods to further the study of the MMPs. The third and final section focuses on in vivo research, particularly with respect to cancer models, degradation of the extracellular matrix, and MMP involvement in other disease states. Written and edited by leaders in the field, Matrix Metalloproteinase Biology addresses the rapidly growth in MMP research, and will be an invaluable resource to advanced students and researchers studying cell and molecular biology.
Holdings
Item type Current library Call number Status Date due Barcode Item holds
Ebrary Ebrary Afghanistan Available EBKAF-N0001467
Ebrary Ebrary Algeria Available
Ebrary Ebrary Cyprus Available
Ebrary Ebrary Egypt Available
Ebrary Ebrary Libya Available
Ebrary Ebrary Morocco Available
Ebrary Ebrary Nepal Available EBKNP-N0001467
Ebrary Ebrary Sudan Available
Ebrary Ebrary Tunisia Available
Total holds: 0

Intro -- Title Page -- Copyright -- Table of Contents -- List of Contributors -- Chapter 1: Matrix Metalloproteinases: From Structure to Function -- 1.1 Introduction -- 1.2 Structures of MMPs -- 1.3 Overview of MMP substrate specificity -- 1.4 Selective mechanisms of action -- Acknowledgments -- References -- Chapter 2: Dynamics and Mechanism of Substrate Recognition by Matrix Metalloproteases -- 2.1 Introduction -- 2.2 Conformational flexibility of MMPs is inexorably linked to collagen proteolysis -- 2.3 Dynamics of MMP-2 and MMP-9 interaction with gelatin -- 2.4 Surface diffusion: a common mechanism for substrate interaction adapted by MMP-2 and MMP-9 -- 2.5 Dynamics of MMP interaction with collagen fibrils -- 2.6 Mechanism of interaction of MMP-1, MMP-2, MMP-9, and MMP-14 with collagen substrate involves surface diffusion -- 2.7 Mechanism of MMP-1 diffusion on native collagen fibrils -- 2.8 Triple helical collagen cleavage-diffusion coupling -- 2.9 Conclusions -- References -- Chapter 3: Matrix Metalloproteinases: From Structure to Function -- 3.1 Introduction -- 3.2 Classification and structural features -- 3.3 Catalytic mechanism -- 3.4 Intra- and inter-domain flexibility -- 3.5 Elastin and collagen degradation -- References -- Chapter 4: Metzincin Modulators -- 4.1 Inhibitors -- Summary and future directions -- References -- Chapter 5: Therapeutics Targeting Matrix Metalloproteinases -- 5.1 Introduction -- 5.2 Peptidomimetic MMP inhibitors -- 5.3 Structure-based MMPI drug design -- 5.4 Mechanism-based MMPI design -- 5.5 Allosteric MMPI design -- 5.6 Macromolecular MMP inhibitors -- 5.7 Chemically-Modified tetracyclines -- 5.8 Alternative approaches -- 5.9 MMPs as anti-targets -- 5.10 Conclusions -- References -- Chapter 6: Matrix Metalloproteinase Modification of Extracellular Matrix-Mediated Signaling -- 6.1 Introduction.

6.2 The extracellular matrix as a source for signaling ligands -- 6.3 ECM and mechanosensory signal transduction -- 6.4 Matrix remodeling and modification of mechano-sensory signaling -- 6.5 Conclusions and future directions -- References -- Chapter 7: Meprin and ADAM Metalloproteases: Two Sides of the Same Coin? -- 7.1 Introduction -- 7.2 Meprin metalloproteases -- 7.3 Structure of meprin α and meprin β -- 7.4 Proteomics for the identification of meprin substrates -- 7.5 Meprins in health and disease -- 7.6 Proteolytic back-and-forth of meprins and ADAMs -- 7.7 Collagen fibril formation -- 7.8 Angiogenesis and cancer -- 7.9 Inflammation -- 7.10 ADAM Proteases -- 7.11 The ADAM family of proteases -- 7.12 Orchestration of different pathways by ADAM17 -- 7.13 Regulation of ADAM17 activity -- 7.14 Role of ADAM17 in vivo -- 7.15 Role of ADAM17 in humans -- References -- Chapter 8: Subtracting Matrix out of the Equation: New Key Roles of Matrix Metalloproteinases in Innate Immunity and Disease -- 8.1 The tale of a Frog's tail -- 8.2 The MMP family -- 8.3 Making the cut as immune regulators -- 8.4 Enter the "omics" era: genomics, proteomics and degradomics -- 8.5 ECM versus Non-ECM MMP substrates -- 8.6 Moonlighting protein substrates: intracellular proteins cleaved outside the cell -- 8.7 Intracellular protein substrates cleaved inside the cell by MMPs -- 8.8 Non-proteolytic roles of MMPs: missed in the myth? -- 8.9 The fairy TAIL of a frog Has an unexpected ending -- Acknowledgements -- References -- Chapter 9: MMPs: From Genomics to Degradomics -- 9.1 Introduction -- 9.2 Degradomics - an overview -- 9.3 Conclusions -- Acknowledgments -- References -- Chapter 10: MMPs in Biology and Medicine -- 10.1 Introduction -- 10.2 Functional roles of MMPs and ADAMs -- 10.3 MMPs as diagnostic and prognostic biomarkers of cancer.

10.4 MMPs/ADAMs as diagnostic and prognostic biomarkers for non-neoplastic diseases -- 10.5 MMPs as biomarkers of therapeutic efficacy -- 10.6 MMP-specific molecular imaging for noninvasive disease detection -- 10.7 Conclusions -- Acknowledgments -- References -- Index -- End User License Agreement.

Discussing recent advances in the field of matrix metalloproteinase (MMP) research from a multidisciplinary perspective, Matrix Metalloproteinase Biologyis a collection of chapters written by leaders in the field of MMPs.  The book focuses on the challenges of understanding the mechanisms substrate degradation by MMPs, as well as how these enzymes are able to degrade large, highly ordered substrates such as collagen. All topics addressed are considered in relation to disease progression including roles in cancer metastasis, rheumatoid arthritis and other inflammatory diseases. The text first provides an overview of MMPs, focusing on the history, the development and failures of small molecule inhibitors in clinical trials, and work with TIMPS, the endogenous inhibitors of MMPs. These introductory chapters establish the foundation for later discussion of the recent progress on the design of different types of inhibitors, including novel antibody based therapeutics. The following section emphasizes research using novel methods to further the study of the MMPs. The third and final section focuses on in vivo research, particularly with respect to cancer models, degradation of the extracellular matrix, and MMP involvement in other disease states. Written and edited by leaders in the field, Matrix Metalloproteinase Biology addresses the rapidly growth in MMP research, and will be an invaluable resource to advanced students and researchers studying cell and molecular biology.

Description based on publisher supplied metadata and other sources.

Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2019. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.

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