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General and Molecular Pharmacology : Principles of Drug Action.

By: Contributor(s): Publisher: New York : John Wiley & Sons, Incorporated, 2015Copyright date: ©2015Edition: 1st edDescription: 1 online resource (785 pages)Content type:
  • text
Media type:
  • computer
Carrier type:
  • online resource
ISBN:
  • 9781118768594
Subject(s): Genre/Form: Additional physical formats: Print version:: General and Molecular Pharmacology : Principles of Drug ActionDDC classification:
  • 615.1/9
LOC classification:
  • RS403
Online resources:
Contents:
Intro -- Title Page -- Copyright Page -- Contents -- List of Contributors -- Preface -- SECTION 1 INTRODUCTION TO PHARMACOLOGY -- CHAPTER 1 ESSENTIAL LEXICON OF PHARMACOLOGY -- THE SOCIAL IMPACT OF PHARMACOLOGY -- ESSENTIAL LEXICON -- Active Substances -- Pharmacological Disciplines -- Drug-Receptor Interactions -- Measure of the Clinical Response -- TAKE-HOME MESSAGE -- CHAPTER 2 A SHORT HISTORY OF PHARMACOLOGY -- BIRTH AND HISTORICAL DEVELOPMENTS OF PHARMACOLOGY -- From Magical and Natural Remedies of Ancient Medicine to Arabic Alchemy -- From Monastic Medicine to Botanical Gardens -- From Anatomical Renaissance to the "Experienz": Paracelsus' Spagyric -- From Iatrochemistry to the Age of Enlightenment -- From the Search of the Active Principle to the Discovery of Alkaloids and Glucosides -- The Drug Synthesis Revolution: From Handmade to Industrial Production -- MODERN PHARMACOLOGY -- Ehrlich and Chemotherapy: The Concept of Receptor -- The Birth of Modern Pharmacology -- THE BIOTECHNOLOGY ERA AND THE PHARMACOLOGY IN THE THIRD MILLENNIUM -- The Impact of New Biotechnologies: Molecular Biology, Bioinformatics, and Combinatorial Chemistry -- Biological Drugs and Pharmacology Perspectives -- Personalized Therapies and New Sceneries in Pharmaceutical Industry -- TAKE-HOME MESSAGE -- FURTHER READING -- SECTION 2 GETTING THE DRUG TO ITS SITE OF ACTION -- CHAPTER 3 CELLULAR BASIS OF PHARMACOKINETICS -- A QUICK JOURNEY WITH THE DRUG IN THE BODY -- Absorption -- Distribution -- Drug Elimination -- CROSSING CELL MEMBRANES -- Passive Diffusion across Cell Membranes -- Drug Transport across Cell Membranes -- Endocytosis -- DRUG DIFFUSION TO ORGANS AND TISSUES -- Properties of the Most Important Cell Barriers -- TAKE-HOME MESSAGE -- FURTHER READING -- CHAPTER 4 DRUG ABSORPTION AND ADMINISTRATION ROUTES -- GENERAL RULES ABOUT DRUG ABSORPTION RATE.
Partition Coefficient -- Drug Dispersion -- Extension of the Absorbing Surface -- Permeability of the Absorbing Surface -- Vascularization -- ENTERAL ROUTES OF ADMINISTRATION -- Oral Route -- Sublingual and Rectal Routes -- SYSTEMIC PARENTERAL ROUTES OF ADMINISTRATION -- The Intravascular Route -- i.m. Injection -- Subcutaneous and Intradermal Injections -- OTHER ROUTES OF DRUG ADMINISTRATION -- Inhalation Route -- Topical/Regional Routes -- Intracavity Routes -- Dermal or Transcutaneous Route -- Mucosal Routes -- ABSORPTION KINETICS -- General Rules -- Interrelation between Gene Therapy and Drug Delivery Techniques -- TAKE-HOME MESSAGE -- FURTHER READING -- CHAPTER 5 DRUG DISTRIBUTION AND ELIMINATION -- DISTRIBUTION -- Tissues and Avidity for Drugs -- The Apparent Distribution Volume -- Drug Binding to Plasma Proteins -- Factors That Determine the Distribution Rate of Drugs to the Various Compartments -- ELIMINATION -- The Concept of Half-Life -- The Concept of Clearance -- RENAL EXCRETION OF DRUGS -- Glomerular Filtration -- Tubular Functions and Pharmacokinetics -- Active Transport of Organic Anions and Cations -- Factors Determining Renal Clearance of Drugs -- HEPATIC EXCRETION AND ENTEROHEPATIC CYCLE -- Perfusion, Binding to Plasma Proteins, Enzymatic Activity, and Hepatic Clearance -- TAKE-HOME MESSAGE -- FURTHER READING -- CHAPTER 6 DRUG METABOLISM -- METABOLIC MODIFICATION OF DRUG ACTIVITY -- TWO PHASES OF DRUG METABOLISM -- Phase I Reactions -- Phase II Enzymatic Reactions -- EXTRAHEPATIC BIOTRANSFORMATIONS -- Biotransformation by the Intestinal Flora -- PHARMACOMETABOLIC INDUCTION AND INHIBITION -- Induction of Drug Metabolism -- Inhibition of Drug Metabolism -- TAKE-HOME MESSAGE -- FURTHER READING -- CHAPTER 7 CONTROL OF DRUG PLASMA CONCENTRATION -- TIME COURSE OF DRUG PLASMA CONCENTRATION FOLLOWING A SINGLE ADMINISTRATION.
DRUGS DISTRIBUTE TO ORGANS AND TISSUES AND THEN ARE ELIMINATED -- Description of Drug Plasma Concentration Time Course Following a Single Administration -- Area under the Plasma Concentration Curve (AUC) -- The Plasma Concentration Peak -- DRUG PLASMA CONCENTRATION TIME COURSE DURING REPETITIVE ADMINISTRATIONS -- During Repetitive Administrations, the Drug Plasma Concentration Time Course Is Given by the Sum of the Time Courses of the Single Doses -- In a Chronic Therapy at Steady State, Each New Dose Replaces the Drug Amount that has been Eliminated Since the Last Administration -- The Time to Reach the Steady State Depends on the Drug Half‐Life -- Plasma Concentration at Steady State -- The Single Dose to Administer is Computed as a Function of the Interval between Successive Administrations -- Fluctuations of Drug Plasma Concentration at Steady State -- Absorption Kinetics Influence the Amplitude of Oscillations in Plasma Concentration at Steady State -- Loading (Attack) Doses to Rapidly Attain Steady-State Concentration -- MULTICOMPARTMENTAL KINETICS -- Drug Binding to Plasma Proteins and Tissue Equilibration with Plasma -- The Particular Case of the Nephron -- Drugs Redistribution among Compartments -- CORRECTIONS OF THE THERAPEUTIC REGIMEN -- Normally Available Pharmacokinetic Data Are Average Values -- Varying Dosage as a Function of Body Weight and Physical Constitution -- Varying Dosage as a Function of Age -- Dosage Correction in the Presence of Hepatic Pathologies -- Dosage Correction in the Presence of Renal Pathologies -- TAKE-HOME MESSAGE -- FURTHER READING -- SECTION 3 RECEPTORS AND SIGNAL TRANSDUCTION -- CHAPTER 8 DRUG-RECEPTOR INTERACTIONS: QUANTITATIVE AND QUALITATIVE ASPECTS -- GENERAL PROPERTIES OF DRUG RECEPTORS -- Drug Receptors Are Molecules Relevant for Cellular Functions -- Not All Drugs Interact with a Receptor.
Drug Activity Follows to Drug-Receptor Complex Formation -- Drug-Receptor Interaction Is Mostly Mediated by Weak Chemical Bonds -- Reversible or Irreversible Drug-Receptor Interactions -- CHARACTERISTICS OF DRUG-RECEPTOR INTERACTION -- The Relationship between Drug Concentration and Drug-Receptor Complex Is Similar to the Michaelis-Menten Equation -- The Binding Isotherm and Its Linear Transformations Allow to Obtain the Parameters of the Drug-Receptor Interaction -- Receptors Can Be Heterogeneous -- Drug Competition for a Same Receptor Binding Site -- QUANTITATIVE ASPECTS OF DRUG EFFECTS: DOSE-RESPONSE CURVES -- Potency and Efficacy -- FROM DRUG-RECEPTOR INTERACTION TO DRUG RESPONSE -- Occupancy Theory -- Modifications to the Occupancy Assumption -- Efficacy Theory -- Nonlinear Function between Receptor Occupancy and Tissue Response: EC50 Different from Kd -- Constitutively Active Receptors and Inverse Agonists -- Two-State Receptor Model and Beyond: Multiple Receptor States and "Biased" Signaling -- TAKE-HOME MESSAGE -- FURTHER READING -- CHAPTER 9 RECEPTORS AND MODULATION OF THEIR RESPONSE -- CLASSES OF RECEPTORS AND STRATEGIES OF SIGNAL TRANSDUCTION -- Intracellular/Intranuclear Receptors -- Membrane Receptors -- CONTROL OF RECEPTOR LOCALIZATION IN THE CELL MEMBRANE -- INTRACELLULAR TRAFFIC OF CELL RECEPTORS -- How Receptors Reach the Cell Membrane and how Their Number is Regulated -- MODULATION OF RECEPTOR RESPONSES -- RECEPTOR MODULATION BY DRUGS -- TAKE-HOME MESSAGE -- FURTHER READING -- General -- Intracellular Receptors -- Ligand-gated Ion Channels -- G Protein-Coupled Receptors -- Catalytic Receptors -- Chemokine Receptors -- Toll-Like Receptors -- Death Receptors -- CHAPTER 10 ADAPTATION TO DRUG RESPONSE AND DRUG DEPENDENCE -- MOLECULAR, CELLULAR, AND SYSTEMIC ADAPTATION -- Cellular Adaptation -- Effects of Repeated Drug Exposure.
DRUG ADDICTION AS A PARADIGM OF ALLOSTATIC ADAPTATION -- Adaptation and Stages of Drug Addiction -- Research on Drug Addiction -- THERAPY FOR DRUG DEPENDENCE -- TAKE-HOME MESSAGE -- FURTHER READING -- CHAPTER 11 PHARMACOLOGICAL MODULATION OF POSTTRANSLATIONAL MODIFICATIONS -- PROTEIN PHOSPHORYLATION -- Protein Kinases -- Protein Phosphatases -- SUMOylation -- UBIQUITINATION -- GLYCOSYLATION -- ACETYLATION -- HYDROXYLATION -- CARBOXYLATION -- METHYLATION -- S-NITROSYLATION -- DISULFIDE BONDS -- LIPID MODIFICATIONS -- Myristoylation -- Prenylation -- Palmitoylation -- Attachment of Glycosylphosphatidylinositols -- PHARMACOLOGICAL MODULATION OF POST TRANSLATIONAL MODIFICATIONS -- Deacetylase Inhibitors -- Glycosylation Inhibitors -- TAKE-HOME MESSAGE -- FURTHER READING -- CHAPTER 12 CALCIUM HOMEOSTASIS WITHIN THE CELLS -- THE CYTOSOL: A CROSSROAD OF Ca2+ FLUXES -- Free Ca2+ in the Cytosol and Total Cell Calcium -- The High-Affinity Buffering of Cytosolic Proteins -- THE PLASMA MEMBRANE: CHANNELS, PUMPS, AND TRANSPORTERS -- Surface Channels Permeable to Ca2+ -- Surface Pumps and Transporters -- Ca2+ IN INTRACELLULAR ORGANELLES -- The ER: A Rapidly Exchanging Ca2+ Pool -- Mitochondria as Local Buffers of [Ca2+]i -- ER and Mitochondria Allow Rapid Changes of [Ca2+]i within Cells -- [Ca2+]i Control in Other Intracellular Structures -- Local Relevance of Organelle Calcium Pools -- Ca2+ IN CELL PATHOLOGY -- TAKE-HOME MESSAGE -- FURTHER READING -- CHAPTER 13 PHARMACOLOGY OF MAP KINASES -- THE MAPK FAMILY AND THE ACTIVATION MECHANISM -- The ERK Family -- The JNK Family -- The p38 Family -- ERK5 -- MAPK SPECIFICITY -- Duration of Action -- Multiple Enzyme Isoforms -- Subcellular Localization and Interaction with Scaffold Proteins -- miRNAs -- PHARMACOLOGICAL INHIBITION OF MAPK -- Inhibition of the Ras/RAF/MEK/ERK Cascade -- MEK -- RAF -- JNKs -- p38.
TAKE-HOME MESSAGE.
Summary: With a focus on functional relationships between drugs and their targets, this book covers basic and general pharmacology, from a cellular and molecular perspective, with particular attention  to the mechanisms of drug action - the fundamental basis for proper clinical use- without neglecting clinical application, toxicology and pharmacokinetics.     Covers cell and molecular pharmacology, bringing together current research on regulation of drug targets, at a level appropriate for advanced undergrad and graduate students     Discusses the relevance of pharmacokinetics and drug development for the clinical application of drugs     Presents material from the perspective of drug targets and interaction, the theoretical basis of drug action analysis, and drug properties     Focuses on structure-function relationships of drug targets - informing about their biochemical and physiologic functions and experimental and clinical pathways for drug discovery and development     Has a companion website that offers a host of resources: short additional chapters about methodology, topics at the forefront of research, all figures and tables from the book, and Power Point slides.
Holdings
Item type Current library Call number Status Date due Barcode Item holds
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Ebrary Ebrary Algeria Available
Ebrary Ebrary Cyprus Available
Ebrary Ebrary Egypt Available
Ebrary Ebrary Libya Available
Ebrary Ebrary Morocco Available
Ebrary Ebrary Nepal Available EBKNP-N0001465
Ebrary Ebrary Sudan Available
Ebrary Ebrary Tunisia Available
Total holds: 0

Intro -- Title Page -- Copyright Page -- Contents -- List of Contributors -- Preface -- SECTION 1 INTRODUCTION TO PHARMACOLOGY -- CHAPTER 1 ESSENTIAL LEXICON OF PHARMACOLOGY -- THE SOCIAL IMPACT OF PHARMACOLOGY -- ESSENTIAL LEXICON -- Active Substances -- Pharmacological Disciplines -- Drug-Receptor Interactions -- Measure of the Clinical Response -- TAKE-HOME MESSAGE -- CHAPTER 2 A SHORT HISTORY OF PHARMACOLOGY -- BIRTH AND HISTORICAL DEVELOPMENTS OF PHARMACOLOGY -- From Magical and Natural Remedies of Ancient Medicine to Arabic Alchemy -- From Monastic Medicine to Botanical Gardens -- From Anatomical Renaissance to the "Experienz": Paracelsus' Spagyric -- From Iatrochemistry to the Age of Enlightenment -- From the Search of the Active Principle to the Discovery of Alkaloids and Glucosides -- The Drug Synthesis Revolution: From Handmade to Industrial Production -- MODERN PHARMACOLOGY -- Ehrlich and Chemotherapy: The Concept of Receptor -- The Birth of Modern Pharmacology -- THE BIOTECHNOLOGY ERA AND THE PHARMACOLOGY IN THE THIRD MILLENNIUM -- The Impact of New Biotechnologies: Molecular Biology, Bioinformatics, and Combinatorial Chemistry -- Biological Drugs and Pharmacology Perspectives -- Personalized Therapies and New Sceneries in Pharmaceutical Industry -- TAKE-HOME MESSAGE -- FURTHER READING -- SECTION 2 GETTING THE DRUG TO ITS SITE OF ACTION -- CHAPTER 3 CELLULAR BASIS OF PHARMACOKINETICS -- A QUICK JOURNEY WITH THE DRUG IN THE BODY -- Absorption -- Distribution -- Drug Elimination -- CROSSING CELL MEMBRANES -- Passive Diffusion across Cell Membranes -- Drug Transport across Cell Membranes -- Endocytosis -- DRUG DIFFUSION TO ORGANS AND TISSUES -- Properties of the Most Important Cell Barriers -- TAKE-HOME MESSAGE -- FURTHER READING -- CHAPTER 4 DRUG ABSORPTION AND ADMINISTRATION ROUTES -- GENERAL RULES ABOUT DRUG ABSORPTION RATE.

Partition Coefficient -- Drug Dispersion -- Extension of the Absorbing Surface -- Permeability of the Absorbing Surface -- Vascularization -- ENTERAL ROUTES OF ADMINISTRATION -- Oral Route -- Sublingual and Rectal Routes -- SYSTEMIC PARENTERAL ROUTES OF ADMINISTRATION -- The Intravascular Route -- i.m. Injection -- Subcutaneous and Intradermal Injections -- OTHER ROUTES OF DRUG ADMINISTRATION -- Inhalation Route -- Topical/Regional Routes -- Intracavity Routes -- Dermal or Transcutaneous Route -- Mucosal Routes -- ABSORPTION KINETICS -- General Rules -- Interrelation between Gene Therapy and Drug Delivery Techniques -- TAKE-HOME MESSAGE -- FURTHER READING -- CHAPTER 5 DRUG DISTRIBUTION AND ELIMINATION -- DISTRIBUTION -- Tissues and Avidity for Drugs -- The Apparent Distribution Volume -- Drug Binding to Plasma Proteins -- Factors That Determine the Distribution Rate of Drugs to the Various Compartments -- ELIMINATION -- The Concept of Half-Life -- The Concept of Clearance -- RENAL EXCRETION OF DRUGS -- Glomerular Filtration -- Tubular Functions and Pharmacokinetics -- Active Transport of Organic Anions and Cations -- Factors Determining Renal Clearance of Drugs -- HEPATIC EXCRETION AND ENTEROHEPATIC CYCLE -- Perfusion, Binding to Plasma Proteins, Enzymatic Activity, and Hepatic Clearance -- TAKE-HOME MESSAGE -- FURTHER READING -- CHAPTER 6 DRUG METABOLISM -- METABOLIC MODIFICATION OF DRUG ACTIVITY -- TWO PHASES OF DRUG METABOLISM -- Phase I Reactions -- Phase II Enzymatic Reactions -- EXTRAHEPATIC BIOTRANSFORMATIONS -- Biotransformation by the Intestinal Flora -- PHARMACOMETABOLIC INDUCTION AND INHIBITION -- Induction of Drug Metabolism -- Inhibition of Drug Metabolism -- TAKE-HOME MESSAGE -- FURTHER READING -- CHAPTER 7 CONTROL OF DRUG PLASMA CONCENTRATION -- TIME COURSE OF DRUG PLASMA CONCENTRATION FOLLOWING A SINGLE ADMINISTRATION.

DRUGS DISTRIBUTE TO ORGANS AND TISSUES AND THEN ARE ELIMINATED -- Description of Drug Plasma Concentration Time Course Following a Single Administration -- Area under the Plasma Concentration Curve (AUC) -- The Plasma Concentration Peak -- DRUG PLASMA CONCENTRATION TIME COURSE DURING REPETITIVE ADMINISTRATIONS -- During Repetitive Administrations, the Drug Plasma Concentration Time Course Is Given by the Sum of the Time Courses of the Single Doses -- In a Chronic Therapy at Steady State, Each New Dose Replaces the Drug Amount that has been Eliminated Since the Last Administration -- The Time to Reach the Steady State Depends on the Drug Half‐Life -- Plasma Concentration at Steady State -- The Single Dose to Administer is Computed as a Function of the Interval between Successive Administrations -- Fluctuations of Drug Plasma Concentration at Steady State -- Absorption Kinetics Influence the Amplitude of Oscillations in Plasma Concentration at Steady State -- Loading (Attack) Doses to Rapidly Attain Steady-State Concentration -- MULTICOMPARTMENTAL KINETICS -- Drug Binding to Plasma Proteins and Tissue Equilibration with Plasma -- The Particular Case of the Nephron -- Drugs Redistribution among Compartments -- CORRECTIONS OF THE THERAPEUTIC REGIMEN -- Normally Available Pharmacokinetic Data Are Average Values -- Varying Dosage as a Function of Body Weight and Physical Constitution -- Varying Dosage as a Function of Age -- Dosage Correction in the Presence of Hepatic Pathologies -- Dosage Correction in the Presence of Renal Pathologies -- TAKE-HOME MESSAGE -- FURTHER READING -- SECTION 3 RECEPTORS AND SIGNAL TRANSDUCTION -- CHAPTER 8 DRUG-RECEPTOR INTERACTIONS: QUANTITATIVE AND QUALITATIVE ASPECTS -- GENERAL PROPERTIES OF DRUG RECEPTORS -- Drug Receptors Are Molecules Relevant for Cellular Functions -- Not All Drugs Interact with a Receptor.

Drug Activity Follows to Drug-Receptor Complex Formation -- Drug-Receptor Interaction Is Mostly Mediated by Weak Chemical Bonds -- Reversible or Irreversible Drug-Receptor Interactions -- CHARACTERISTICS OF DRUG-RECEPTOR INTERACTION -- The Relationship between Drug Concentration and Drug-Receptor Complex Is Similar to the Michaelis-Menten Equation -- The Binding Isotherm and Its Linear Transformations Allow to Obtain the Parameters of the Drug-Receptor Interaction -- Receptors Can Be Heterogeneous -- Drug Competition for a Same Receptor Binding Site -- QUANTITATIVE ASPECTS OF DRUG EFFECTS: DOSE-RESPONSE CURVES -- Potency and Efficacy -- FROM DRUG-RECEPTOR INTERACTION TO DRUG RESPONSE -- Occupancy Theory -- Modifications to the Occupancy Assumption -- Efficacy Theory -- Nonlinear Function between Receptor Occupancy and Tissue Response: EC50 Different from Kd -- Constitutively Active Receptors and Inverse Agonists -- Two-State Receptor Model and Beyond: Multiple Receptor States and "Biased" Signaling -- TAKE-HOME MESSAGE -- FURTHER READING -- CHAPTER 9 RECEPTORS AND MODULATION OF THEIR RESPONSE -- CLASSES OF RECEPTORS AND STRATEGIES OF SIGNAL TRANSDUCTION -- Intracellular/Intranuclear Receptors -- Membrane Receptors -- CONTROL OF RECEPTOR LOCALIZATION IN THE CELL MEMBRANE -- INTRACELLULAR TRAFFIC OF CELL RECEPTORS -- How Receptors Reach the Cell Membrane and how Their Number is Regulated -- MODULATION OF RECEPTOR RESPONSES -- RECEPTOR MODULATION BY DRUGS -- TAKE-HOME MESSAGE -- FURTHER READING -- General -- Intracellular Receptors -- Ligand-gated Ion Channels -- G Protein-Coupled Receptors -- Catalytic Receptors -- Chemokine Receptors -- Toll-Like Receptors -- Death Receptors -- CHAPTER 10 ADAPTATION TO DRUG RESPONSE AND DRUG DEPENDENCE -- MOLECULAR, CELLULAR, AND SYSTEMIC ADAPTATION -- Cellular Adaptation -- Effects of Repeated Drug Exposure.

DRUG ADDICTION AS A PARADIGM OF ALLOSTATIC ADAPTATION -- Adaptation and Stages of Drug Addiction -- Research on Drug Addiction -- THERAPY FOR DRUG DEPENDENCE -- TAKE-HOME MESSAGE -- FURTHER READING -- CHAPTER 11 PHARMACOLOGICAL MODULATION OF POSTTRANSLATIONAL MODIFICATIONS -- PROTEIN PHOSPHORYLATION -- Protein Kinases -- Protein Phosphatases -- SUMOylation -- UBIQUITINATION -- GLYCOSYLATION -- ACETYLATION -- HYDROXYLATION -- CARBOXYLATION -- METHYLATION -- S-NITROSYLATION -- DISULFIDE BONDS -- LIPID MODIFICATIONS -- Myristoylation -- Prenylation -- Palmitoylation -- Attachment of Glycosylphosphatidylinositols -- PHARMACOLOGICAL MODULATION OF POST TRANSLATIONAL MODIFICATIONS -- Deacetylase Inhibitors -- Glycosylation Inhibitors -- TAKE-HOME MESSAGE -- FURTHER READING -- CHAPTER 12 CALCIUM HOMEOSTASIS WITHIN THE CELLS -- THE CYTOSOL: A CROSSROAD OF Ca2+ FLUXES -- Free Ca2+ in the Cytosol and Total Cell Calcium -- The High-Affinity Buffering of Cytosolic Proteins -- THE PLASMA MEMBRANE: CHANNELS, PUMPS, AND TRANSPORTERS -- Surface Channels Permeable to Ca2+ -- Surface Pumps and Transporters -- Ca2+ IN INTRACELLULAR ORGANELLES -- The ER: A Rapidly Exchanging Ca2+ Pool -- Mitochondria as Local Buffers of [Ca2+]i -- ER and Mitochondria Allow Rapid Changes of [Ca2+]i within Cells -- [Ca2+]i Control in Other Intracellular Structures -- Local Relevance of Organelle Calcium Pools -- Ca2+ IN CELL PATHOLOGY -- TAKE-HOME MESSAGE -- FURTHER READING -- CHAPTER 13 PHARMACOLOGY OF MAP KINASES -- THE MAPK FAMILY AND THE ACTIVATION MECHANISM -- The ERK Family -- The JNK Family -- The p38 Family -- ERK5 -- MAPK SPECIFICITY -- Duration of Action -- Multiple Enzyme Isoforms -- Subcellular Localization and Interaction with Scaffold Proteins -- miRNAs -- PHARMACOLOGICAL INHIBITION OF MAPK -- Inhibition of the Ras/RAF/MEK/ERK Cascade -- MEK -- RAF -- JNKs -- p38.

TAKE-HOME MESSAGE.

With a focus on functional relationships between drugs and their targets, this book covers basic and general pharmacology, from a cellular and molecular perspective, with particular attention  to the mechanisms of drug action - the fundamental basis for proper clinical use- without neglecting clinical application, toxicology and pharmacokinetics.     Covers cell and molecular pharmacology, bringing together current research on regulation of drug targets, at a level appropriate for advanced undergrad and graduate students     Discusses the relevance of pharmacokinetics and drug development for the clinical application of drugs     Presents material from the perspective of drug targets and interaction, the theoretical basis of drug action analysis, and drug properties     Focuses on structure-function relationships of drug targets - informing about their biochemical and physiologic functions and experimental and clinical pathways for drug discovery and development     Has a companion website that offers a host of resources: short additional chapters about methodology, topics at the forefront of research, all figures and tables from the book, and Power Point slides.

Description based on publisher supplied metadata and other sources.

Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2019. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.

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