Bioinspired and Biomimetic Polymer Systems for Drug and Gene Delivery.

By: Gu, ZhongweiPublisher: Somerset : John Wiley & Sons, Incorporated, 2015Copyright date: ©2014Edition: 1st edDescription: 1 online resource (362 pages)Content type: text Media type: computer Carrier type: online resourceISBN: 9783527672738Subject(s): Drug delivery systemsGenre/Form: Electronic books. Additional physical formats: Print version:: Bioinspired and Biomimetic Polymer Systems for Drug and Gene DeliveryDDC classification: 615.19 LOC classification: RS199.5 -- .G8 2015ebOnline resources: Click to View
Contents:
Intro -- Bioinspired and Biomimetic Polymer Systems for Drug and Gene Delivery -- Contents -- List of Contributors -- Preface -- Chapter 1 Backbone Degradable and Coiled-Coil Based Macromolecular Therapeutics -- 1.1 Introduction -- 1.2 Water-Soluble Polymers as Carriers of Anticancer Drugs -- 1.2.1 First Generation Conjugates - Design, Synthesis, and Activity -- 1.2.2 Analysis of Design Factors That Need Attention -- 1.2.2.1 Design of Conjugates for the Treatment of Noncancerous Diseases -- 1.2.2.2 Combination Therapy Using Polymer-Bound Therapeutics -- 1.2.2.3 New Targeting Strategies -- 1.2.2.4 Relationship Between Detailed Structure of the Conjugates and Their Properties -- 1.2.2.5 Impact of Binding a Drug to a Polymer on the Mechanism of Action -- 1.2.2.6 Mechanism of Internalization and Subcellular Trafficking -- 1.2.2.7 Relationship Between the Molecular Weight of the Carrier and the Efficacy of the Conjugate -- 1.2.3 Design of Second Generation Conjugates - Long-Circulating and Backbone Degradable -- 1.2.3.1 RAFT Copolymerization for the Synthesis of Conjugates -- 1.2.3.2 Click Reactions for Chain Extension into Multiblock Copolymers -- 1.2.3.3 Biological Properties of Long-Circulating Macromolecular Therapeutics -- 1.2.4 Summary of Part 2 and Future Prospects -- 1.3 Drug-Free Macromolecular Therapeutics - A New Paradigm in Drug Delivery -- 1.3.1 Biorecognition in Hybrid Polymer Systems -- 1.3.2 Coiled-Coils in Biomedical Systems -- 1.3.3 Coiled-Coil Based Drug-Free Macromolecular Therapeutics: Design, In Vitro, and In Vivo Activity -- 1.3.4 Potential, Limitations, and Future Prospect of Drug-Free Macromolecular Therapeutics -- 1.4 General Summary and Outlook -- Acknowledgments -- References -- Chapter 2 Dendritic Polymers as Targeting Nanoscale Drug Delivery Systems for Cancer Therapy -- 2.1 Introduction.
2.2 Functional Dendritic Polymers Based Drug Delivery Vehicles for Targeting Tumor Therapy via EPR Effect -- 2.2.1 Functional Dendritic Polymers for Encapsulation of Anticancer Drugs -- 2.2.2 Chemical Conjugation Functional Dendritic Polymers as Drug Delivery Systems -- 2.3 Tumor Targeting Moieties Functionalized Dendritic Drug Delivery Vehicles for Cancer Therapy -- 2.4 Conclusion -- References -- Chapter 3 Composite Colloidal Nanosystems for Targeted Delivery and Sensing -- 3.1 Introduction -- 3.1.1 Working Toolkit -- 3.1.2 Engineering a Multifunctional Carrier -- 3.2 Objective -- 3.3 Cellular Behavior of the Carrier -- 3.3.1 Intracellular Fate -- 3.3.2 Biocompatibility -- 3.4 Applications -- 3.4.1 Delivery with Multifunctional PEM Capsules -- 3.4.1.1 Magnetic Targeting and Magnetofection -- 3.4.1.2 Strategies for Controlled Opening -- 3.4.2 Intracellular Ion Sensing -- 3.5 Conclusions -- Abbreviations -- References -- Chapter 4 Polymeric Micelles for Cancer-Targeted Drug Delivery -- 4.1 Introduction -- 4.2 Micelle Formulations in Clinical Development -- 4.3 Particle Size of Micelles -- 4.4 Morphology of Micelles -- 4.5 Targeting Design of Micelles for Enhanced Accumulation and Cell Internalization -- 4.6 Functional Designs of Micelles -- 4.7 Design of Micelles for Gene Delivery -- 4.8 Challenge and Future Perspective -- References -- Chapter 5 Biomimetic Polymers for In Vivo Drug Delivery -- 5.1 Introduction -- 5.2 Commonly Used Biomimetic Polymers and Their Applications in DDS -- 5.2.1 Polylactones and Their Modifications -- 5.2.1.1 Poly(lactic acid) (PLA) -- 5.2.1.2 Poly(lactic-co-glycolic acid) (PLGA) -- 5.2.1.3 Poly(ε-caprolactone) (PCL) -- 5.2.2 Dendrimer -- 5.2.2.1 Structure and Properties of Dendrimers -- 5.2.2.2 Types of Dendrimers -- 5.2.2.3 Applications of Dendrimers as Carriers in Drug Delivery Systems -- 5.2.3 Synthetic Polypeptides.
5.3 Challenges and Perspectives -- References -- Chapter 6 Drug Delivery from Protein-Based Nanoparticles -- 6.1 Introduction -- 6.2 Preparation of Protein-Based Nanoparticles -- 6.2.1 Desolvation -- 6.2.2 Emulsification -- 6.2.3 Coacervation -- 6.2.4 Polymer-Monomer Pair Reaction System -- 6.3 Drug Delivery from Albumin-Based Nanoparticles -- 6.3.1 Albumin-Based Nanoparticles as Drug Carriers -- 6.3.2 Targeting Ligand-Functionalized Albumin-Based Nanoparticles -- 6.3.3 Nanoparticle Albumin-Bound (nab) Technology -- 6.4 Drug Delivery from Gelatin-Based Nanoparticles -- 6.4.1 Gelatin-Based Nanoparticles as Drug Carriers -- 6.4.2 Targeting Ligand-Functionalized Gelatin-Based Nanoparticles -- 6.4.3 Site-Specific Drug Delivery System -- 6.5 Drug Delivery from Other Protein-Based Nanoparticles -- References -- Chapter 7 Polymeric Gene Carriers -- 7.1 Gene Therapy and Gene Carriers -- 7.1.1 Gene Therapy -- 7.1.1.1 The Concept of Gene Therapy -- 7.1.1.2 Development and the Present Situation of Gene Therapy -- 7.1.1.3 Methods and Strategies of Gene Therapy -- 7.1.1.4 Research Contents and Challenges of Gene Therapy -- 7.1.2 Gene Carriers -- 7.1.2.1 The Concept of Gene Carrier -- 7.1.2.2 The Necessity of the Gene Carrier -- 7.1.2.3 Requirements of Gene Carrier -- 7.1.2.4 Classification of Gene Carrier -- 7.2 Polymeric Gene Carriers -- 7.2.1 Cationic Polymer Gene Carriers -- 7.2.1.1 Process of the Polycation Vector Mediated Gene Delivery -- 7.2.1.2 Categories and Research Situation of the Cationic Polymer Gene Vector -- 7.3 PEI Grafting Modification Polymeric Gene Carriers -- 7.3.1 Amino Acid Derivatives Modified Polymeric Gene Carriers -- 7.3.1.1 Poly(glutamic acid) Derivatives Modified PEI -- 7.3.1.2 Polyphenylalanine Derivatives Modified PEI -- 7.3.2 PEG Modified Hyperbranched PEI -- 7.4 Low Molecular Weight (LWM) PEI Base Polymeric Gene Carriers.
7.4.1 Crosslinked Polycations -- 7.4.1.1 Crosslinked Polycation OEI-CBA -- 7.4.1.2 Crosslinked Polycation OEI-PBLG-PEGDA -- 7.4.1.3 Hexachlorotriphosphazene Crosslinked Polycation -- 7.4.2 Grafted Polycations -- 7.4.2.1 Grafted Cationic Polymer MP-g-OEI -- 7.4.2.2 Graft Cationic Polymer N-PAE-g-OEI -- 7.4.2.3 Graft Cationic Polymer mPEG-b-PMCC-g-OEI -- 7.5 Targeted Shielding System for Polymeric Gene Carriers -- 7.5.1 Static Shielding System -- 7.5.1.1 Poly(glutamine acid) Shielding System and PEGylations -- 7.5.1.2 Sulfonamides Related Shielding System -- 7.5.2 Other Design Strategies of Cationic Gene Carrier -- 7.6 Conclusion -- References -- Chapter 8 pH-Sensitive Polymeric Nanoparticles as Carriers for Cancer Therapy and Imaging -- 8.1 Introduction -- 8.2 pH-Sensitive Polymers -- 8.2.1 pH-Sensitive Anionic Polymers -- 8.2.2 pH-Sensitive Cationic Polymers -- 8.2.3 pH-Sensitive Neutral Polymers -- 8.3 pH-Sensitive Polymers as Drug Carriers -- 8.3.1 pH-Sensitive Polymer-Drug Conjugates -- 8.3.2 pH-Sensitive Polymeric Micelles -- 8.3.3 pH-Sensitive Polymersomes -- 8.3.4 pH-Sensitive Polymer-Inorganic Hybrid Nanoparticles -- 8.3.5 pH-Sensitive Dendrimers -- 8.4 pH-Sensitive Polymers for Bioimaging -- 8.5 Conclusions -- References -- Chapter 9 Charge-Reversal Polymers for Biodelivery -- 9.1 Applications of Cationic Polymers in Biodelivery -- 9.2 Barriers for Cationic Polymers in In vitro and In vivo Applications -- 9.3 Characteristic pH Gradients in Tumor Interstitium and Endo/Lysosomes -- 9.4 Chemistry of Charge-Reversal Polymers Based on Acid-Labile Amides -- 9.4.1 pHe-Triggered Charge-Reversal -- 9.4.2 pHL-Triggered Charge-Reversal -- 9.5 Applications of Charge-Reversal Polymers in Biodelivery Systems -- 9.5.1 Charge-Reversal in Cancer Drug Delivery -- 9.5.2 Charge-Reversal in Gene Delivery -- 9.5.3 Charge-Reversal in Protein Delivery.
9.5.4 Charge-Reversal Incorporated with Inorganic Materials -- 9.6 Perspectives -- References -- Chapter 10 Phenylboronic Acid-Containing Glucose-Responsive Polymer Materials: Synthesis and Applications in Drug Delivery -- 10.1 Introduction -- 10.2 PBA-Containing Polymers Operating Under Physiological Conditions -- 10.3 Chemically Crosslinked PBA-Based Gels -- 10.4 Self-Assembled PBA-Based Polymer Micelles -- 10.5 Self-Assembled PBA-Based Polymersomes -- 10.6 Perspectives -- References -- Chapter 11 Extracellular pH-Activated Nanocarriers for Enhanced Drug Delivery to Tumors -- 11.1 Introduction -- 11.2 Passive and Active Tumor Targeting -- 11.3 Targeting the Extracellular pH (pHe) in Tumors -- 11.4 Extracellular pH-Induced Drug Delivery to Tumors -- 11.5 Ligand Exposure by a Shielding/Deshielding Method -- 11.6 Surface Charge Reversing Nanoparticles -- 11.6.1 Enhanced Cellular Uptake by Surface Charge Reversing Nanoparticles -- 11.6.2 Overcoming MDR by Surface Charge Reversing Nanoparticles -- 11.6.3 Enhanced Delivery of siRNA by Surface-Charge Reversing Nanoparticles -- 11.7 Conclusion -- References -- Chapter 12 Stimulation-Sensitive Drug Delivery Systems -- 12.1 Introduction -- 12.2 pH-Sensitive Delivery Systems -- 12.2.1 pH-Sensitive Micellar Delivery Systems -- 12.2.2 pH-Sensitive Polymer- Drug Conjugates -- 12.2.3 pH-Sensitive Dendrimers -- 12.2.4 pH-Sensitive Liposomes -- 12.3 Thermo-Sensitive Delivery Systems -- 12.4 Biomolecule-Sensitive Delivery Systems -- 12.4.1 Enzyme-Sensitive Nanocarriers -- 12.4.2 Reduction- Responsive Conjugates -- 12.5 Other Environmentally Sensitive Nanocarriers -- 12.6 Outlook -- References -- Index -- EULA.
Summary: Here, front-line researchers in the booming field of nanobiotechnology describe the most promising approaches for bioinspired drug delivery, encompassing small molecule delivery, delivery of therapeutic proteins and gene delivery. The carriers surveyed include polymeric, proteinaceous and lipid systems on the nanoscale, with a focus on their adaptability for different cargoes and target tissues. Thanks to the broad coverage of carriers as well as cargoes discussed, every researcher in the field will find valuable information here.
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Intro -- Bioinspired and Biomimetic Polymer Systems for Drug and Gene Delivery -- Contents -- List of Contributors -- Preface -- Chapter 1 Backbone Degradable and Coiled-Coil Based Macromolecular Therapeutics -- 1.1 Introduction -- 1.2 Water-Soluble Polymers as Carriers of Anticancer Drugs -- 1.2.1 First Generation Conjugates - Design, Synthesis, and Activity -- 1.2.2 Analysis of Design Factors That Need Attention -- 1.2.2.1 Design of Conjugates for the Treatment of Noncancerous Diseases -- 1.2.2.2 Combination Therapy Using Polymer-Bound Therapeutics -- 1.2.2.3 New Targeting Strategies -- 1.2.2.4 Relationship Between Detailed Structure of the Conjugates and Their Properties -- 1.2.2.5 Impact of Binding a Drug to a Polymer on the Mechanism of Action -- 1.2.2.6 Mechanism of Internalization and Subcellular Trafficking -- 1.2.2.7 Relationship Between the Molecular Weight of the Carrier and the Efficacy of the Conjugate -- 1.2.3 Design of Second Generation Conjugates - Long-Circulating and Backbone Degradable -- 1.2.3.1 RAFT Copolymerization for the Synthesis of Conjugates -- 1.2.3.2 Click Reactions for Chain Extension into Multiblock Copolymers -- 1.2.3.3 Biological Properties of Long-Circulating Macromolecular Therapeutics -- 1.2.4 Summary of Part 2 and Future Prospects -- 1.3 Drug-Free Macromolecular Therapeutics - A New Paradigm in Drug Delivery -- 1.3.1 Biorecognition in Hybrid Polymer Systems -- 1.3.2 Coiled-Coils in Biomedical Systems -- 1.3.3 Coiled-Coil Based Drug-Free Macromolecular Therapeutics: Design, In Vitro, and In Vivo Activity -- 1.3.4 Potential, Limitations, and Future Prospect of Drug-Free Macromolecular Therapeutics -- 1.4 General Summary and Outlook -- Acknowledgments -- References -- Chapter 2 Dendritic Polymers as Targeting Nanoscale Drug Delivery Systems for Cancer Therapy -- 2.1 Introduction.

2.2 Functional Dendritic Polymers Based Drug Delivery Vehicles for Targeting Tumor Therapy via EPR Effect -- 2.2.1 Functional Dendritic Polymers for Encapsulation of Anticancer Drugs -- 2.2.2 Chemical Conjugation Functional Dendritic Polymers as Drug Delivery Systems -- 2.3 Tumor Targeting Moieties Functionalized Dendritic Drug Delivery Vehicles for Cancer Therapy -- 2.4 Conclusion -- References -- Chapter 3 Composite Colloidal Nanosystems for Targeted Delivery and Sensing -- 3.1 Introduction -- 3.1.1 Working Toolkit -- 3.1.2 Engineering a Multifunctional Carrier -- 3.2 Objective -- 3.3 Cellular Behavior of the Carrier -- 3.3.1 Intracellular Fate -- 3.3.2 Biocompatibility -- 3.4 Applications -- 3.4.1 Delivery with Multifunctional PEM Capsules -- 3.4.1.1 Magnetic Targeting and Magnetofection -- 3.4.1.2 Strategies for Controlled Opening -- 3.4.2 Intracellular Ion Sensing -- 3.5 Conclusions -- Abbreviations -- References -- Chapter 4 Polymeric Micelles for Cancer-Targeted Drug Delivery -- 4.1 Introduction -- 4.2 Micelle Formulations in Clinical Development -- 4.3 Particle Size of Micelles -- 4.4 Morphology of Micelles -- 4.5 Targeting Design of Micelles for Enhanced Accumulation and Cell Internalization -- 4.6 Functional Designs of Micelles -- 4.7 Design of Micelles for Gene Delivery -- 4.8 Challenge and Future Perspective -- References -- Chapter 5 Biomimetic Polymers for In Vivo Drug Delivery -- 5.1 Introduction -- 5.2 Commonly Used Biomimetic Polymers and Their Applications in DDS -- 5.2.1 Polylactones and Their Modifications -- 5.2.1.1 Poly(lactic acid) (PLA) -- 5.2.1.2 Poly(lactic-co-glycolic acid) (PLGA) -- 5.2.1.3 Poly(ε-caprolactone) (PCL) -- 5.2.2 Dendrimer -- 5.2.2.1 Structure and Properties of Dendrimers -- 5.2.2.2 Types of Dendrimers -- 5.2.2.3 Applications of Dendrimers as Carriers in Drug Delivery Systems -- 5.2.3 Synthetic Polypeptides.

5.3 Challenges and Perspectives -- References -- Chapter 6 Drug Delivery from Protein-Based Nanoparticles -- 6.1 Introduction -- 6.2 Preparation of Protein-Based Nanoparticles -- 6.2.1 Desolvation -- 6.2.2 Emulsification -- 6.2.3 Coacervation -- 6.2.4 Polymer-Monomer Pair Reaction System -- 6.3 Drug Delivery from Albumin-Based Nanoparticles -- 6.3.1 Albumin-Based Nanoparticles as Drug Carriers -- 6.3.2 Targeting Ligand-Functionalized Albumin-Based Nanoparticles -- 6.3.3 Nanoparticle Albumin-Bound (nab) Technology -- 6.4 Drug Delivery from Gelatin-Based Nanoparticles -- 6.4.1 Gelatin-Based Nanoparticles as Drug Carriers -- 6.4.2 Targeting Ligand-Functionalized Gelatin-Based Nanoparticles -- 6.4.3 Site-Specific Drug Delivery System -- 6.5 Drug Delivery from Other Protein-Based Nanoparticles -- References -- Chapter 7 Polymeric Gene Carriers -- 7.1 Gene Therapy and Gene Carriers -- 7.1.1 Gene Therapy -- 7.1.1.1 The Concept of Gene Therapy -- 7.1.1.2 Development and the Present Situation of Gene Therapy -- 7.1.1.3 Methods and Strategies of Gene Therapy -- 7.1.1.4 Research Contents and Challenges of Gene Therapy -- 7.1.2 Gene Carriers -- 7.1.2.1 The Concept of Gene Carrier -- 7.1.2.2 The Necessity of the Gene Carrier -- 7.1.2.3 Requirements of Gene Carrier -- 7.1.2.4 Classification of Gene Carrier -- 7.2 Polymeric Gene Carriers -- 7.2.1 Cationic Polymer Gene Carriers -- 7.2.1.1 Process of the Polycation Vector Mediated Gene Delivery -- 7.2.1.2 Categories and Research Situation of the Cationic Polymer Gene Vector -- 7.3 PEI Grafting Modification Polymeric Gene Carriers -- 7.3.1 Amino Acid Derivatives Modified Polymeric Gene Carriers -- 7.3.1.1 Poly(glutamic acid) Derivatives Modified PEI -- 7.3.1.2 Polyphenylalanine Derivatives Modified PEI -- 7.3.2 PEG Modified Hyperbranched PEI -- 7.4 Low Molecular Weight (LWM) PEI Base Polymeric Gene Carriers.

7.4.1 Crosslinked Polycations -- 7.4.1.1 Crosslinked Polycation OEI-CBA -- 7.4.1.2 Crosslinked Polycation OEI-PBLG-PEGDA -- 7.4.1.3 Hexachlorotriphosphazene Crosslinked Polycation -- 7.4.2 Grafted Polycations -- 7.4.2.1 Grafted Cationic Polymer MP-g-OEI -- 7.4.2.2 Graft Cationic Polymer N-PAE-g-OEI -- 7.4.2.3 Graft Cationic Polymer mPEG-b-PMCC-g-OEI -- 7.5 Targeted Shielding System for Polymeric Gene Carriers -- 7.5.1 Static Shielding System -- 7.5.1.1 Poly(glutamine acid) Shielding System and PEGylations -- 7.5.1.2 Sulfonamides Related Shielding System -- 7.5.2 Other Design Strategies of Cationic Gene Carrier -- 7.6 Conclusion -- References -- Chapter 8 pH-Sensitive Polymeric Nanoparticles as Carriers for Cancer Therapy and Imaging -- 8.1 Introduction -- 8.2 pH-Sensitive Polymers -- 8.2.1 pH-Sensitive Anionic Polymers -- 8.2.2 pH-Sensitive Cationic Polymers -- 8.2.3 pH-Sensitive Neutral Polymers -- 8.3 pH-Sensitive Polymers as Drug Carriers -- 8.3.1 pH-Sensitive Polymer-Drug Conjugates -- 8.3.2 pH-Sensitive Polymeric Micelles -- 8.3.3 pH-Sensitive Polymersomes -- 8.3.4 pH-Sensitive Polymer-Inorganic Hybrid Nanoparticles -- 8.3.5 pH-Sensitive Dendrimers -- 8.4 pH-Sensitive Polymers for Bioimaging -- 8.5 Conclusions -- References -- Chapter 9 Charge-Reversal Polymers for Biodelivery -- 9.1 Applications of Cationic Polymers in Biodelivery -- 9.2 Barriers for Cationic Polymers in In vitro and In vivo Applications -- 9.3 Characteristic pH Gradients in Tumor Interstitium and Endo/Lysosomes -- 9.4 Chemistry of Charge-Reversal Polymers Based on Acid-Labile Amides -- 9.4.1 pHe-Triggered Charge-Reversal -- 9.4.2 pHL-Triggered Charge-Reversal -- 9.5 Applications of Charge-Reversal Polymers in Biodelivery Systems -- 9.5.1 Charge-Reversal in Cancer Drug Delivery -- 9.5.2 Charge-Reversal in Gene Delivery -- 9.5.3 Charge-Reversal in Protein Delivery.

9.5.4 Charge-Reversal Incorporated with Inorganic Materials -- 9.6 Perspectives -- References -- Chapter 10 Phenylboronic Acid-Containing Glucose-Responsive Polymer Materials: Synthesis and Applications in Drug Delivery -- 10.1 Introduction -- 10.2 PBA-Containing Polymers Operating Under Physiological Conditions -- 10.3 Chemically Crosslinked PBA-Based Gels -- 10.4 Self-Assembled PBA-Based Polymer Micelles -- 10.5 Self-Assembled PBA-Based Polymersomes -- 10.6 Perspectives -- References -- Chapter 11 Extracellular pH-Activated Nanocarriers for Enhanced Drug Delivery to Tumors -- 11.1 Introduction -- 11.2 Passive and Active Tumor Targeting -- 11.3 Targeting the Extracellular pH (pHe) in Tumors -- 11.4 Extracellular pH-Induced Drug Delivery to Tumors -- 11.5 Ligand Exposure by a Shielding/Deshielding Method -- 11.6 Surface Charge Reversing Nanoparticles -- 11.6.1 Enhanced Cellular Uptake by Surface Charge Reversing Nanoparticles -- 11.6.2 Overcoming MDR by Surface Charge Reversing Nanoparticles -- 11.6.3 Enhanced Delivery of siRNA by Surface-Charge Reversing Nanoparticles -- 11.7 Conclusion -- References -- Chapter 12 Stimulation-Sensitive Drug Delivery Systems -- 12.1 Introduction -- 12.2 pH-Sensitive Delivery Systems -- 12.2.1 pH-Sensitive Micellar Delivery Systems -- 12.2.2 pH-Sensitive Polymer- Drug Conjugates -- 12.2.3 pH-Sensitive Dendrimers -- 12.2.4 pH-Sensitive Liposomes -- 12.3 Thermo-Sensitive Delivery Systems -- 12.4 Biomolecule-Sensitive Delivery Systems -- 12.4.1 Enzyme-Sensitive Nanocarriers -- 12.4.2 Reduction- Responsive Conjugates -- 12.5 Other Environmentally Sensitive Nanocarriers -- 12.6 Outlook -- References -- Index -- EULA.

Here, front-line researchers in the booming field of nanobiotechnology describe the most promising approaches for bioinspired drug delivery, encompassing small molecule delivery, delivery of therapeutic proteins and gene delivery. The carriers surveyed include polymeric, proteinaceous and lipid systems on the nanoscale, with a focus on their adaptability for different cargoes and target tissues. Thanks to the broad coverage of carriers as well as cargoes discussed, every researcher in the field will find valuable information here.

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