Natural Products and Cancer Signaling : Isoprenoids, Polyphenols and Flavonoids.

By: Tamanoi, FuyuhikoContributor(s): Bathaie, S. ZahraSeries: Issn SerPublisher: Saint Louis : Elsevier Science & Technology, 2014Copyright date: ©2014Description: 1 online resource (279 pages)Content type: text Media type: computer Carrier type: online resourceISBN: 9780128025277Subject(s): Cancer -- Alternative treatment.;Cancer -- TreatmentGenre/Form: Electronic books. Additional physical formats: Print version:: Natural Products and Cancer Signaling : Isoprenoids, Polyphenols and FlavonoidsDDC classification: 616.994061 LOC classification: RC271.A62 -- .E599 2014ebOnline resources: Click to View
Contents:
Front Cover -- The Enzymes: Natural Products and Cancer Signaling: Isoprenoids, Polyphenols and Flavonoids -- Copyright -- Contents -- Contributors -- Preface -- Chapter One: Introduction -- References -- Chapter Two: Perillyl Alcohol (Monoterpene Alcohol), Limonene -- 1. Introduction -- 2. Perillyl Alcohol -- 2.1. Perillyl Alcohol Mechanism of Action in Cancer Therapy and Pharmacokinetics -- 2.2. Perillyl Alcohol Biosafety and Adverse Effects in Clinical Application and Clinical Trials -- 3. Limonene -- 3.1. Limonene Pharmacokinetics -- 3.2. Limonene Anticancer Activity and Clinical Trials -- 3.3. Limonene Mechanisms of Action, Targets, and Clinical Applications -- 3.4. Limonene Biosafety and Adverse Effects -- 4. Concluding Remarks -- Acknowledgment -- References -- Chapter Three: Ganoderic Acid and Lucidenic Acid (Triterpenoid) -- 1. Introduction -- 2. Lucidenic Acids and Ganoderic Acids from Ganoderma Species -- 2.1. The Sources of Lucidenic Acids and Ganoderic Acids -- 2.2. The Biosynthesis of Ganoderic Acids -- 2.3. Optimization of the Fermentation Process -- 3. Biological Functions of Lucidenic Acids and Ganoderic Acids -- 3.1. Cytotoxic and Apoptotic Effects -- 3.2. Cell Cycle Arrest -- 3.3. Anti-invasive Effect -- 3.4. Autophagy -- 3.5. Anti-inflammatory Effect -- 3.6. Antiosteoclastogenesis -- 3.7. Antiasthma -- 3.8. Antihepatitis B Activity -- 4. Pharmacokinetics of Ganoderic Acids -- 5. Conclusion -- References -- Chapter Four: Anticancer Effect and Molecular Targets of Saffron Carotenoids -- 1. Introduction -- 2. Anticancer Effect of Saffron and Its Carotenoids -- 3. Comparing the Efficacy of Crocetin, Crocin, and Other Components -- 4. Liposome Formulation of Saffron Compounds -- 5. Effect of Crocetin and Crocin on Macromolecule Synthesis and Structure -- 5.1. Effect on DNA, RNA, and Protein Synthesis -- 5.2. Protein Binding.
6. Effects on Cell Cycle, Apoptosis, and Signaling Pathways -- 7. Role of Saffron Components on Chemoprevention -- 8. Molecular Mechanisms Involved in the Protective Effect of Saffron Components against Various Damages in Different Tissues -- 9. Antioxidant and Anti-inflammatory Effects of Saffron -- 10. Safety -- 11. Other Mechanisms -- 12. Conclusions -- References -- Chapter Five: Zerumbone from Ginger (Monoterpenoid) -- 1. Introduction -- 2. Characteristic Feature -- 3. Target Pathways by Zerumbone -- 3.1. Survival -- 3.1.1. Caspase Family -- 3.1.2. Bcl Family -- 3.1.3. c-FLIP -- 3.1.4. G2/M Cell Cycle -- 3.2. Proliferation -- 3.2.1. Cyclin B1/CDK1 -- 3.2.2. Tumor Necrosis Factor -- 3.3. Invasion -- 3.4. Angiogenesis -- 4. Nuclear Factor-Kappa B -- 5. Future Perspectives -- References -- Chapter Six: Research Progress on Natural Triterpenoid Saponins in the Chemoprevention and Chemotherapy of Cancer -- 1. Introduction -- 2. Triterpenoid Saponins in the Prevention and Therapy of Cancers -- 3. Anticancer Properties and Molecular Mechanisms of Triterpenoid Saponins -- 3.1. Inhibition of Proliferation -- 3.2. Induction of Apoptosis and Autophagy -- 3.2.1. Apoptosis -- 3.2.2. Autophagy -- 3.3. Attenuation of Invasion and Metastasis -- 3.4. Inhibition of Angiogenesis -- 3.5. Anti-inflammatory Effects -- 3.6. Antioxidative Effects -- 3.7. Inhibition of Multidrug Resistance -- 3.8. Inhibition of CSCs -- 3.9. Modulation of MicroRNAs -- 4. Structure-Activity Relationships of Anticancer Activities of Triterpenoid Saponins -- 5. Clinical Studies -- 6. Summary and Perspectives -- References -- Chapter Seven: Neem Limonoids as Anticancer Agents: Modulation of Cancer Hallmarks and Oncogenic Signaling -- 1. Introduction -- 2. Cytotoxicity of Neem Limonoids -- 3. Neem Limonoids and Hallmarks of Cancer -- 3.1. Inhibition of Cell Proliferation.
3.2. Apoptosis Induction -- 3.3. Effects on Tumor Invasion and Angiogenesis -- 3.4. Anti-Inflammatory Effects -- 3.5. Immunomodulatory Effects -- 3.6. Antioxidant Activity -- 4. Oncogenic Signaling -- 4.1. NF-κB Signaling -- 4.2. Wnt/β-Catenin Signaling -- 4.3. PI3K/Akt Signaling -- 4.4. MAPK Signaling -- 4.5. JAK/STAT Signaling -- 5. Conclusions and Future Perspectives -- References -- Chapter Eight: Curcumin: A Potent Modulator of Multiple Enzymes in Multiple Cancers -- 1. Introduction -- 2. Structure-Activity Relationship of Curcumin -- 3. Curcumin Binds and Modulates Multiple Enzymes -- 3.1. Lipoxygenases -- 3.2. Cyclooxygenases -- 3.3. Xanthine Oxidase -- 3.4. Proteasomes -- 3.5. Ca2+-ATPase of Sarcoplasmic Reticulum -- 3.6. Matrix Metalloproteinases -- 3.7. Histone Acetyltransferases and Deacetylases -- 3.8. DNA Methyltransferase 1 -- 3.9. DNA Polymerase λ -- 3.10. Ribonucleases -- 3.11. Glyoxalase I -- 4. Curcumin Binds and Modulates PKs -- 4.1. Protein Kinases -- 4.2. Cellular Sarcoma -- 4.3. Glycogen Synthase Kinase-3β -- 4.4. ErbB2 -- 5. Curcumin Directly Binds and Modulates Protein Reductases -- 5.1. Thioredoxin Reductase -- 5.2. Aldose Reductase -- 6. Others -- 7. Curcumin Clinical Trials in Cancer -- 8. Future Perspectives -- Acknowledgment -- References -- Chapter Nine: Molecular Targets of Honokiol: A Promising Phytochemical for Effective Cancer Management -- 1. Introduction -- 2. Honokiol: Structure-Activity Relationship -- 3. Anticancer Effect of Honokiol -- 3.1. Cell-Cycle Arrest -- 3.2. Apoptosis Induction -- 3.3. Antiangiogenic Effect -- 3.4. Inhibition of Migration and Invasion -- 4. Molecular Targets of Honokiol -- 4.1. Signal Transducers and Activators of Transcription -- 4.2. Nuclear Factor Kappa B -- 4.3. Beta-Catenin -- 4.4. Phosphoinositide 3-Kinase/Akt/Mammalian Target of Rapamycin -- 4.5. Epidermal Growth Factor Receptor.
4.6. Vascular Endothelial Growth Factor and Its Receptor -- 4.7. Hypoxia-Inducible Factors -- 4.8. Cyclooxygenases -- 5. Pharmacokinetics of Honokiol -- 6. Conclusion and Future Outlook -- Acknowledgments -- References -- Chapter Ten: Effects of Tea Catechins on Cancer Signaling Pathways -- 1. Introduction -- 2. Chemistry, Bioavailability, and Biotransformation of Tea Catechins -- 2.1. Chemistry -- 2.2. Bioavailability -- 2.3. Biotransformation -- 3. Inhibition of Tumorigenesis by Tea Catechins in Animal Models and Possible Mechanisms -- 3.1. Inhibition of Tumorigenesis in the Digestive Tract -- 3.2. Inhibition of Lung Tumorigenesis -- 3.3. Inhibition of Prostate Carcinogenesis -- 3.4. Human Studies -- 4. Biochemical Activities of Tea Catechins -- 4.1. Antioxidant and Pro-oxidative Activities In Vitro and In Vivo -- 4.2. High-Affinity Binding Proteins as Targets of EGCG -- 4.3. Inhibition of Enzyme Activities -- 5. Modulating Signaling Pathways and Cell Functions -- 5.1. Inhibition of Receptor Tyrosine Kinases and Other Receptors -- 5.2. Effects on 67LR -- 5.3. Inhibition of Wnt Signaling -- 5.4. Epigenetic Mechanisms -- 5.4.1. Affecting Epigenetic DNA Methylation and Histone Modification -- 5.4.2. Effect on MicroRNA -- 5.5. Other Mechanisms -- 5.5.1. Modulating p53-Dependent Events -- 5.5.2. Binding to Lipids -- 5.5.3. Binding to Nucleic Acids -- 6. Issues in Extrapopulating Studies In Vitro to Situations In Vivo -- 7. Concluding Remarks -- Acknowledgments -- References -- Author Index -- Subject Index -- Color Plate.
Summary: Natural compounds from a variety of natural resources including plants have emerged as important source of anticancer drug development. This special issue will highlight the significant advance in elucidating mechanisms of action of these natural compounds, focusing especially on isoprenoids and polyphenols/flavonoids. Informs and updates on all the latest developments in the field Contributions from leading authorities and industry experts.
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Front Cover -- The Enzymes: Natural Products and Cancer Signaling: Isoprenoids, Polyphenols and Flavonoids -- Copyright -- Contents -- Contributors -- Preface -- Chapter One: Introduction -- References -- Chapter Two: Perillyl Alcohol (Monoterpene Alcohol), Limonene -- 1. Introduction -- 2. Perillyl Alcohol -- 2.1. Perillyl Alcohol Mechanism of Action in Cancer Therapy and Pharmacokinetics -- 2.2. Perillyl Alcohol Biosafety and Adverse Effects in Clinical Application and Clinical Trials -- 3. Limonene -- 3.1. Limonene Pharmacokinetics -- 3.2. Limonene Anticancer Activity and Clinical Trials -- 3.3. Limonene Mechanisms of Action, Targets, and Clinical Applications -- 3.4. Limonene Biosafety and Adverse Effects -- 4. Concluding Remarks -- Acknowledgment -- References -- Chapter Three: Ganoderic Acid and Lucidenic Acid (Triterpenoid) -- 1. Introduction -- 2. Lucidenic Acids and Ganoderic Acids from Ganoderma Species -- 2.1. The Sources of Lucidenic Acids and Ganoderic Acids -- 2.2. The Biosynthesis of Ganoderic Acids -- 2.3. Optimization of the Fermentation Process -- 3. Biological Functions of Lucidenic Acids and Ganoderic Acids -- 3.1. Cytotoxic and Apoptotic Effects -- 3.2. Cell Cycle Arrest -- 3.3. Anti-invasive Effect -- 3.4. Autophagy -- 3.5. Anti-inflammatory Effect -- 3.6. Antiosteoclastogenesis -- 3.7. Antiasthma -- 3.8. Antihepatitis B Activity -- 4. Pharmacokinetics of Ganoderic Acids -- 5. Conclusion -- References -- Chapter Four: Anticancer Effect and Molecular Targets of Saffron Carotenoids -- 1. Introduction -- 2. Anticancer Effect of Saffron and Its Carotenoids -- 3. Comparing the Efficacy of Crocetin, Crocin, and Other Components -- 4. Liposome Formulation of Saffron Compounds -- 5. Effect of Crocetin and Crocin on Macromolecule Synthesis and Structure -- 5.1. Effect on DNA, RNA, and Protein Synthesis -- 5.2. Protein Binding.

6. Effects on Cell Cycle, Apoptosis, and Signaling Pathways -- 7. Role of Saffron Components on Chemoprevention -- 8. Molecular Mechanisms Involved in the Protective Effect of Saffron Components against Various Damages in Different Tissues -- 9. Antioxidant and Anti-inflammatory Effects of Saffron -- 10. Safety -- 11. Other Mechanisms -- 12. Conclusions -- References -- Chapter Five: Zerumbone from Ginger (Monoterpenoid) -- 1. Introduction -- 2. Characteristic Feature -- 3. Target Pathways by Zerumbone -- 3.1. Survival -- 3.1.1. Caspase Family -- 3.1.2. Bcl Family -- 3.1.3. c-FLIP -- 3.1.4. G2/M Cell Cycle -- 3.2. Proliferation -- 3.2.1. Cyclin B1/CDK1 -- 3.2.2. Tumor Necrosis Factor -- 3.3. Invasion -- 3.4. Angiogenesis -- 4. Nuclear Factor-Kappa B -- 5. Future Perspectives -- References -- Chapter Six: Research Progress on Natural Triterpenoid Saponins in the Chemoprevention and Chemotherapy of Cancer -- 1. Introduction -- 2. Triterpenoid Saponins in the Prevention and Therapy of Cancers -- 3. Anticancer Properties and Molecular Mechanisms of Triterpenoid Saponins -- 3.1. Inhibition of Proliferation -- 3.2. Induction of Apoptosis and Autophagy -- 3.2.1. Apoptosis -- 3.2.2. Autophagy -- 3.3. Attenuation of Invasion and Metastasis -- 3.4. Inhibition of Angiogenesis -- 3.5. Anti-inflammatory Effects -- 3.6. Antioxidative Effects -- 3.7. Inhibition of Multidrug Resistance -- 3.8. Inhibition of CSCs -- 3.9. Modulation of MicroRNAs -- 4. Structure-Activity Relationships of Anticancer Activities of Triterpenoid Saponins -- 5. Clinical Studies -- 6. Summary and Perspectives -- References -- Chapter Seven: Neem Limonoids as Anticancer Agents: Modulation of Cancer Hallmarks and Oncogenic Signaling -- 1. Introduction -- 2. Cytotoxicity of Neem Limonoids -- 3. Neem Limonoids and Hallmarks of Cancer -- 3.1. Inhibition of Cell Proliferation.

3.2. Apoptosis Induction -- 3.3. Effects on Tumor Invasion and Angiogenesis -- 3.4. Anti-Inflammatory Effects -- 3.5. Immunomodulatory Effects -- 3.6. Antioxidant Activity -- 4. Oncogenic Signaling -- 4.1. NF-κB Signaling -- 4.2. Wnt/β-Catenin Signaling -- 4.3. PI3K/Akt Signaling -- 4.4. MAPK Signaling -- 4.5. JAK/STAT Signaling -- 5. Conclusions and Future Perspectives -- References -- Chapter Eight: Curcumin: A Potent Modulator of Multiple Enzymes in Multiple Cancers -- 1. Introduction -- 2. Structure-Activity Relationship of Curcumin -- 3. Curcumin Binds and Modulates Multiple Enzymes -- 3.1. Lipoxygenases -- 3.2. Cyclooxygenases -- 3.3. Xanthine Oxidase -- 3.4. Proteasomes -- 3.5. Ca2+-ATPase of Sarcoplasmic Reticulum -- 3.6. Matrix Metalloproteinases -- 3.7. Histone Acetyltransferases and Deacetylases -- 3.8. DNA Methyltransferase 1 -- 3.9. DNA Polymerase λ -- 3.10. Ribonucleases -- 3.11. Glyoxalase I -- 4. Curcumin Binds and Modulates PKs -- 4.1. Protein Kinases -- 4.2. Cellular Sarcoma -- 4.3. Glycogen Synthase Kinase-3β -- 4.4. ErbB2 -- 5. Curcumin Directly Binds and Modulates Protein Reductases -- 5.1. Thioredoxin Reductase -- 5.2. Aldose Reductase -- 6. Others -- 7. Curcumin Clinical Trials in Cancer -- 8. Future Perspectives -- Acknowledgment -- References -- Chapter Nine: Molecular Targets of Honokiol: A Promising Phytochemical for Effective Cancer Management -- 1. Introduction -- 2. Honokiol: Structure-Activity Relationship -- 3. Anticancer Effect of Honokiol -- 3.1. Cell-Cycle Arrest -- 3.2. Apoptosis Induction -- 3.3. Antiangiogenic Effect -- 3.4. Inhibition of Migration and Invasion -- 4. Molecular Targets of Honokiol -- 4.1. Signal Transducers and Activators of Transcription -- 4.2. Nuclear Factor Kappa B -- 4.3. Beta-Catenin -- 4.4. Phosphoinositide 3-Kinase/Akt/Mammalian Target of Rapamycin -- 4.5. Epidermal Growth Factor Receptor.

4.6. Vascular Endothelial Growth Factor and Its Receptor -- 4.7. Hypoxia-Inducible Factors -- 4.8. Cyclooxygenases -- 5. Pharmacokinetics of Honokiol -- 6. Conclusion and Future Outlook -- Acknowledgments -- References -- Chapter Ten: Effects of Tea Catechins on Cancer Signaling Pathways -- 1. Introduction -- 2. Chemistry, Bioavailability, and Biotransformation of Tea Catechins -- 2.1. Chemistry -- 2.2. Bioavailability -- 2.3. Biotransformation -- 3. Inhibition of Tumorigenesis by Tea Catechins in Animal Models and Possible Mechanisms -- 3.1. Inhibition of Tumorigenesis in the Digestive Tract -- 3.2. Inhibition of Lung Tumorigenesis -- 3.3. Inhibition of Prostate Carcinogenesis -- 3.4. Human Studies -- 4. Biochemical Activities of Tea Catechins -- 4.1. Antioxidant and Pro-oxidative Activities In Vitro and In Vivo -- 4.2. High-Affinity Binding Proteins as Targets of EGCG -- 4.3. Inhibition of Enzyme Activities -- 5. Modulating Signaling Pathways and Cell Functions -- 5.1. Inhibition of Receptor Tyrosine Kinases and Other Receptors -- 5.2. Effects on 67LR -- 5.3. Inhibition of Wnt Signaling -- 5.4. Epigenetic Mechanisms -- 5.4.1. Affecting Epigenetic DNA Methylation and Histone Modification -- 5.4.2. Effect on MicroRNA -- 5.5. Other Mechanisms -- 5.5.1. Modulating p53-Dependent Events -- 5.5.2. Binding to Lipids -- 5.5.3. Binding to Nucleic Acids -- 6. Issues in Extrapopulating Studies In Vitro to Situations In Vivo -- 7. Concluding Remarks -- Acknowledgments -- References -- Author Index -- Subject Index -- Color Plate.

Natural compounds from a variety of natural resources including plants have emerged as important source of anticancer drug development. This special issue will highlight the significant advance in elucidating mechanisms of action of these natural compounds, focusing especially on isoprenoids and polyphenols/flavonoids. Informs and updates on all the latest developments in the field Contributions from leading authorities and industry experts.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2019. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.

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