Knobil and Neill's Physiology of Reproduction : Two-Volume Set.

By: Plant, Tony M
Contributor(s): Zeleznik, Anthony J
Publisher: San Diego : Elsevier Science & Technology, 2015Copyright date: ©2015Edition: 4th edDescription: 1 online resource (10218 pages)Content type: text Media type: computer Carrier type: online resourceISBN: 9780123977694Subject(s): Mammals -- Physiology.;ReproductionGenre/Form: Electronic books. Additional physical formats: Print version:: Knobil and Neill's Physiology of Reproduction : Two-Volume SetDDC classification: 573.619 LOC classification: QP251 .P525 2014Online resources: Click to View
Contents:
e9780123971753v1 -- Front Cover -- KNOBIL AND NEILL'S PHYSIOLOGY OF REPRODUCTION -- Copyright -- Illustration Credits -- Contents -- Contributors -- Introduction -- Preface -- Foreword* by Roy O. Greep -- Foreword by M. Susan Smith -- VOLUME 1 -- SECTION 1 - GAMETES, FERTILIZATIONAND EMBRYOGENESIS -- Chapter 1 - Mammalian Meiosis -- INTRODUCTION -- INITIATION OF MEIOSIS IN MAMMALS -- PROPHASE I -- CHROMOSOME SEGREGATION AT METAPHASE I (MI) AND MEIOTIC PROGRESSION -- DISORDERS OF MEIOSIS -- CONCLUSION -- Acknowledgments -- References -- Chapter 2 - The Mammalian Oocyte -- INTRODUCTION -- CELL BIOLOGY OF THE OOCYTE -- THE GROWTH PHASE OF OOGENESIS -- MATURATION PHASE OF OOGENESIS: THE FINAL ACT -- CLINICAL PARAMETERS OF OOCYTE BIOLOGY -- CONCLUSION -- Acknowledgments -- References -- Chapter 3 - The Spermatozoon -- INTRODUCTION -- THE SPERM PLASMA MEMBRANE -- THE SPERM HEAD -- THE FLAGELLUM -- CONCLUSION -- References -- Chapter 4 - Fertilization in Mammals -- INTRODUCTION -- SPERM CAPACITATION -- SPERM-EGG INTERACTION -- SPERM-EGG PLASMA MEMBRANE INTERACTIONS -- EVENTS FOLLOWING SPERM-EGG MEMBRANE FUSION -- SIGNALING PATHWAYS RESPONSIBLE FOR THE EVENTS OF EGG ACTIVATION -- CONCLUSION -- ADDENDUM -- Acknowledgments -- References -- Chapter 5 - Gamete and Zygote Transport -- INTRODUCTION -- SPERM TRANSPORT -- OOCYTE AND EMBRYO TRANSPORT IN THE OVIDUCT -- CONCLUSION -- References -- Chapter 6 - Preimplantation Embryo Development and Primordial Germ Cell Lineage Specification -- INTRODUCTION -- EMBRYOGENESIS -- EMBRYONIC STEM CELLS -- GERM LINE DEVELOPMENT -- GONADAL STEM CELLS -- GENERATION OF GAMETES FROM PLURIPOTENT STEM CELLS -- CONCLUSION -- Acknowledgment -- References -- Chapter 7 - Sex Determination and Differentiation -- INTRODUCTION -- CHROMOSOMAL SEX -- GONADAL SEX -- PHENOTYPIC SEX -- CONCLUSION -- References.
SECTION 2 - GONADAL STEROIDS, PITUITARY AND HYPOTHALAMUS -- Chapter 8 - Human Steroid Biosynthesis -- INTRODUCTION -- GENERAL CONCEPTS -- THE CONVERSION OF CHOLESTEROL TO PREGNENOLONE AND MITOCHONDRIAL STEROID METABOLISM -- STEROID HYDROXYLATION AND THE MICROSOMAL P450 ENZYMES -- HSDS, THE TERMINAL STEPS, AND PERIPHERAL METABOLISM -- STEROID SULFONATION -- STEROID DEGRADATION AND EXCRETION -- PATHWAYS -- COMPARISON WITH OTHER SPECIES -- CONCLUSION -- References -- Chapter 9 - Gonadal Steroid Action -- INTRODUCTION -- TRANSCRIPTIONAL ACTIONS OF GONADAL STEROIDS -- NONTRANSCRIPTIONAL EFFECTORS OF GONADAL STEROIDS -- STEROID SIGNALING VIA MEMBRANE RECEPTORS -- COREGULATORS AND GONADAL STEROID PHYSIOLOGY -- INFORMATIC APPROACHES AND TRANSCRIPTIONAL REGULATION BY GONADAL STEROIDS -- CONCLUSION -- References -- Chapter 10 - Gonadotropes and Gonadotropin-Releasing Hormone Signaling -- INTRODUCTION -- GONADOTROPES -- PITUITARY ACTIONS AND MECHANISMS OF ACTION OF GNRH -- AUTOCRINE AND PARACRINE REGULATION OF GONADOTROPES -- CONCLUSION -- References -- Chapter 11 - Physiology of the Adult Gonadotropin-Releasing Hormone Neuronal Network -- INTRODUCTION -- THE GNRH NEURON -- COMPONENTS OF THE GNRH NEURONAL NETWORK -- SYNCHRONIZATION AND PULSATILITY -- HETEROGENEITY WITHIN THE GNRH NEURONAL PHENOTYPE -- ESTROUS CYCLE PLASTICITY -- CONCLUSION -- References -- Chapter 12 - Hypothalamic Control of Prolactin Secretion, and the Multiple Reproductive Functions of Prolactin -- INTRODUCTION -- THE PROLACTIN RECEPTOR AND SIGNAL TRANSDUCTION -- NEUROENDOCRINE CONTROL OF PROLACTIN SECRETION -- LACTOTROPH FUNCTION -- PATTERNS OF PROLACTIN SECRETION -- REPRODUCTIVE FUNCTIONS OF PROLACTIN -- PROLACTIN-INDUCED ADAPTIVE RESPONSES CONTRIBUTING TO SUCCESSFUL REPRODUCTION -- REPRODUCTIVE ACTIONS OF PROLACTIN IN THE MALE -- PROLACTIN AND REPRODUCTIVE DISORDERS -- CONCLUSION.
References -- Chapter 13 - Central Nervous System Control of Oxytocin Secretion during Lactation -- INTRODUCTION -- MILK EJECTION IN RESPONSE TO SUCKLING IS AN ATYPICAL NEURONAL REFLEX -- THE BEHAVIOR OF OT NEURONS DURING MILK EJECTION-THE RAT MODEL -- THE AFFERENT PATHWAY MEDIATING MILK EJECTION -- NEUROTRANSMITTERS/NEUROMODULATORS MEDIATING THE MILK EJECTION REFLEX -- ELECTROPHYSIOLOGICAL PROPERTIES OF OT NEURONS AND THEIR PLASTICITY DURING LACTATION -- SYNAPTIC PLASTICITY DURING LACTATION -- A MODEL FOR MILK EJECTION -- CONCLUSION -- Acknowledgments -- References -- SECTION 3 - MALE REPRODUCTIVE SYSTEM -- Chapter 14 - Testicular Development -- INTRODUCTION -- ANATOMICAL, HISTOLOGICAL, AND MORPHOMETRIC DEVELOPMENT -- CONTROL OF TESTIS DEVELOPMENT -- GERM CELLS -- TESTICULAR DEVELOPMENT AND ADULT HEALTH -- CONCLUSION -- References -- Chapter 15 - Spermatogonial Stem Cells and Spermatogenesis -- INTRODUCTION -- SPERMATOGONIAL STEM CELLS AND SPERMATOGENIC LINEAGE DEVELOPMENT -- EXPERIMENTAL TOOLS FOR STUDYING SPERMATOGONIAL STEM CELLS -- THE SPERMATOGONIAL STEM CELL NICHE -- MOLECULAR MECHANISMS GOVERNING SSC DEVELOPMENTAL FATE -- SPERMATOGONIAL STEM CELL AGING -- TRANSGENESIS -- REGENERATIVE POTENTIAL OF SPERMATOGONIAL STEM CELLS AND TRANSLATION TO THE CLINIC -- CONCLUSION -- Acknowledgments -- References -- Chapter 16 - Hormone Signaling in the Testis -- INTRODUCTION -- LUTEINIZING HORMONE -- TESTOSTERONE -- FOLLICLE-STIMULATING HORMONE -- THYROID HORMONE -- ESTROGEN -- ACTIVIN AND INHIBIN -- OTHER HORMONES -- CONCLUSION -- References -- Chapter 17 - The Epididymis -- INTRODUCTION -- DEVELOPMENT OF THE EPIDIDYMIS -- STRUCTURAL ORGANIZATION OF THE EPIDIDYMIS -- FUNCTIONS TAKING PLACE IN THE LUMINAL COMPARTMENT -- REGULATION OF EPIDIDYMAL FUNCTIONS -- MAJOR PROTEIN FAMILIES IN THE EPIDIDYMIS AND THEIR REGULATION -- AGING.
THE EPIDIDYMIS AS TARGET FOR XENOBIOTICS -- CONCLUSION -- Acknowledgments -- References -- Chapter 18 - Accessory Sex Glands in the Male -- INTRODUCTION -- ANATOMY AND HISTOLOGY -- EMBRYOLOGY AND DEVELOPMENT -- FUNCTION OF SEX ACCESSORY TISSUES -- REGULATION OF THE ADULT PROSTATE -- DISEASES OF THE PROSTATE GLAND -- CONCLUSION -- References -- Chapter 19 - The Immunophysiology of Male Reproduction -- INTRODUCTION -- STRUCTURE AND FUNCTION OF THE MALE REPRODUCTIVE TRACT RELEVANT TO IMMUNOPHYSIOLOGY -- THE IMMUNE SYSTEM AND ITS ENDOCRINE CONTROL -- IMMUNE CELLS OF THE MALE REPRODUCTIVE TRACT -- IMMUNOLOGICAL AND INFLAMMATORY MEDIATORS IN THE TESTIS -- EFFECTS OF IMMUNE CELLS AND INFLAMMATION ON MALE REPRODUCTION -- AUTOIMMUNITY IN THE MALE REPRODUCTIVE TRACT -- IMMUNE PRIVILEGE IN THE MALE REPRODUCTIVE TRACT -- INNATE IMMUNITY IN THE MALE REPRODUCTIVE TRACT: THE RESPONSE TO INFECTIONS AND TUMORS -- IMPLICATIONS, APPLICATIONS, AND THE NEXT 10YEARS -- CONCLUSION -- References -- SECTION 4 - FEMALE REPRODUCTIVE SYSTEM -- Chapter 20 - Gonadotropin Signaling in the Ovary -- INTRODUCTION -- FSH SIGNALS PROMOTE FOLLICULAR MATURATION -- FSH SIGNALING PATHWAYS THAT STIMULATE GRANULOSA CELL DIFFERENTIATION AND PROLIFERATION: CAMP AND PKA-DEPENDENT SIGNALING -- CROSS TALK AMONG FSH-REGULATED SIGNALING PATHWAYS AND TRANSCRIPTIONAL ACTIVATORS TO REGULATE GENE EXPRESSION DURING GRANULOSA CE... -- LH SIGNALS THAT REGULATE THECA CELL FUNCTIONS -- THE LH SURGE PROMOTES OOCYTE MATURATION, OVULATION, AND CORPUS LUTEUM FORMATION -- MECHANISMS BY WHICH LH STIMULATES OOCYTE MATURATION, OVULATION, AND LUTEINIZATION -- MOLECULAR BASIS FOR THE DIFFERENTIAL REGULATION OF TARGET GENE EXPRESSION BY FSH IN PREANTRAL AND LH IN PREOVULATORY GRANULOSA C... -- CONCLUSION -- Acknowledgments -- References -- Chapter 21 - Follicular Development: Mouse, Sheep, and Human Models.
INTRODUCTION -- MORPHOLOGY OF FOLLICULOGENESIS -- PRIMORDIAL FOLLICLE FORMATION -- THE PRIMORDIAL TO PRIMARY FOLLICLE TRANSITION -- REGULATION OF FOLLICULOGENESIS BY TGFΒ FAMILY SIGNALING IN THE OVARY -- TRANSCRIPTION FACTORS IN PREANTRAL-STAGE FOLLICULOGENESIS -- ANTRAL FOLLICLE DEVELOPMENT -- METABOLIC INFLUENCES ON FOLLICLE DEVELOPMENT -- CONCLUSION -- Acknowledgments -- References -- Chapter 22 - Ovulation -- INTRODUCTION -- OVULATION: A PERFORMANCE PLAYED BY MANY ACTORS -- SETTING THE STAGE: GRANULOSA CELL FUNCTIONS IN PREOVULATORY FOLLICLES -- ON-STAGE ACT I: LINKING THE LH RECEPTOR TO OTHER SIGNALING PATHWAYS IN GRANULOSA CELLS -- ON-STAGE ACT II: SIGNAL CONNECTIONS BETWEEN GRANULOSA CELLS AND THE CUMULUS CELL-OOCYTE COMPLEX DURING OVULATION -- ON-STAGE ACT III: THE OOCYTE REIGNS AT CENTER STAGE -- ON-STAGE ACT IV: KEY TRANSCRIPTION FACTORS THAT IMPACT OVULATION -- ON STAGE ACT V: KEY PROTEASES IN OVULATION -- ON STAGE ACT VI: CUMULUS CELLS HAVE IMMUNE-LIKE FUNCTIONS AND A DISTINCT FATE -- OFF-STAGE AND BEHIND THE SCENES: FOLLICLE ATRESIA AND GRANULOSA CELL APOPTOSIS -- TRANSLATIONAL CLINICAL CONSIDERATIONS -- CONCLUSION -- References -- Chapter 23 - Structure, Function, and Regulation of the Corpus Luteum -- INTRODUCTION -- CLASSIFICATION OF TYPES OF CORPORA LUTEA -- LUTEINIZATION -- LUTEOLYSIS -- REGULATION OF LUTEAL STRUCTURE AND FUNCTION -- LUTEAL CELL TYPES AND THEIR REGULATION -- CONCLUSION -- Acknowledgments -- References -- Chapter 24 - Human Oviduct and Endometrium: Changes over the Menstrual Cycle -- INTRODUCTION -- ANATOMY, EMBRYOLOGY, AND HISTOLOGY: AN OVERVIEW -- OVIDUCT -- ENDOMETRIUM -- CONCLUSION -- References -- Chapter 25 - Steroid Receptors in the Uterus and Ovary -- INTRODUCTION -- THE STEROID RECEPTORS -- SEX STEROID RECEPTORS IN UTERINE FUNCTION -- SEX STEROID RECEPTORS AND OVARIAN FUNCTION -- SUMMARY -- CONCLUSION.
References.
Summary: The Fourth Edition of Knobil & Neill continues to serve as a reference aid for research, to provide the historical context to current research, and most importantly as an aid for graduate teaching on a broad range of topics in human and comparative reproduction. In the decade since the publication of the last edition, the study of reproductive physiology has undergone monumental changes. Chief among these advances are in the areas of stem cell development, signaling pathways, the role of inflammation in the regulatory processes in the various tissues, and the integration of new animal models which have led to a greater understanding of human disease. The new edition synthesizes all of this new information at the molecular, cellular, and organismal levels of organization and present modern physiology a more understandable and comparative context. The Fourth Edition has been extensively revised, reflecting new fundamental advancements in this rapidly advancing field. Provides a common language for researchers across the fields of physiology, endocrinology, and biology to discuss their understanding of reproduction. Saves academic researchers time in quickly accessing the very latest details on reproductive physiology, as opposed to searching through thousands of journal articles.
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e9780123971753v1 -- Front Cover -- KNOBIL AND NEILL'S PHYSIOLOGY OF REPRODUCTION -- Copyright -- Illustration Credits -- Contents -- Contributors -- Introduction -- Preface -- Foreword* by Roy O. Greep -- Foreword by M. Susan Smith -- VOLUME 1 -- SECTION 1 - GAMETES, FERTILIZATIONAND EMBRYOGENESIS -- Chapter 1 - Mammalian Meiosis -- INTRODUCTION -- INITIATION OF MEIOSIS IN MAMMALS -- PROPHASE I -- CHROMOSOME SEGREGATION AT METAPHASE I (MI) AND MEIOTIC PROGRESSION -- DISORDERS OF MEIOSIS -- CONCLUSION -- Acknowledgments -- References -- Chapter 2 - The Mammalian Oocyte -- INTRODUCTION -- CELL BIOLOGY OF THE OOCYTE -- THE GROWTH PHASE OF OOGENESIS -- MATURATION PHASE OF OOGENESIS: THE FINAL ACT -- CLINICAL PARAMETERS OF OOCYTE BIOLOGY -- CONCLUSION -- Acknowledgments -- References -- Chapter 3 - The Spermatozoon -- INTRODUCTION -- THE SPERM PLASMA MEMBRANE -- THE SPERM HEAD -- THE FLAGELLUM -- CONCLUSION -- References -- Chapter 4 - Fertilization in Mammals -- INTRODUCTION -- SPERM CAPACITATION -- SPERM-EGG INTERACTION -- SPERM-EGG PLASMA MEMBRANE INTERACTIONS -- EVENTS FOLLOWING SPERM-EGG MEMBRANE FUSION -- SIGNALING PATHWAYS RESPONSIBLE FOR THE EVENTS OF EGG ACTIVATION -- CONCLUSION -- ADDENDUM -- Acknowledgments -- References -- Chapter 5 - Gamete and Zygote Transport -- INTRODUCTION -- SPERM TRANSPORT -- OOCYTE AND EMBRYO TRANSPORT IN THE OVIDUCT -- CONCLUSION -- References -- Chapter 6 - Preimplantation Embryo Development and Primordial Germ Cell Lineage Specification -- INTRODUCTION -- EMBRYOGENESIS -- EMBRYONIC STEM CELLS -- GERM LINE DEVELOPMENT -- GONADAL STEM CELLS -- GENERATION OF GAMETES FROM PLURIPOTENT STEM CELLS -- CONCLUSION -- Acknowledgment -- References -- Chapter 7 - Sex Determination and Differentiation -- INTRODUCTION -- CHROMOSOMAL SEX -- GONADAL SEX -- PHENOTYPIC SEX -- CONCLUSION -- References.

SECTION 2 - GONADAL STEROIDS, PITUITARY AND HYPOTHALAMUS -- Chapter 8 - Human Steroid Biosynthesis -- INTRODUCTION -- GENERAL CONCEPTS -- THE CONVERSION OF CHOLESTEROL TO PREGNENOLONE AND MITOCHONDRIAL STEROID METABOLISM -- STEROID HYDROXYLATION AND THE MICROSOMAL P450 ENZYMES -- HSDS, THE TERMINAL STEPS, AND PERIPHERAL METABOLISM -- STEROID SULFONATION -- STEROID DEGRADATION AND EXCRETION -- PATHWAYS -- COMPARISON WITH OTHER SPECIES -- CONCLUSION -- References -- Chapter 9 - Gonadal Steroid Action -- INTRODUCTION -- TRANSCRIPTIONAL ACTIONS OF GONADAL STEROIDS -- NONTRANSCRIPTIONAL EFFECTORS OF GONADAL STEROIDS -- STEROID SIGNALING VIA MEMBRANE RECEPTORS -- COREGULATORS AND GONADAL STEROID PHYSIOLOGY -- INFORMATIC APPROACHES AND TRANSCRIPTIONAL REGULATION BY GONADAL STEROIDS -- CONCLUSION -- References -- Chapter 10 - Gonadotropes and Gonadotropin-Releasing Hormone Signaling -- INTRODUCTION -- GONADOTROPES -- PITUITARY ACTIONS AND MECHANISMS OF ACTION OF GNRH -- AUTOCRINE AND PARACRINE REGULATION OF GONADOTROPES -- CONCLUSION -- References -- Chapter 11 - Physiology of the Adult Gonadotropin-Releasing Hormone Neuronal Network -- INTRODUCTION -- THE GNRH NEURON -- COMPONENTS OF THE GNRH NEURONAL NETWORK -- SYNCHRONIZATION AND PULSATILITY -- HETEROGENEITY WITHIN THE GNRH NEURONAL PHENOTYPE -- ESTROUS CYCLE PLASTICITY -- CONCLUSION -- References -- Chapter 12 - Hypothalamic Control of Prolactin Secretion, and the Multiple Reproductive Functions of Prolactin -- INTRODUCTION -- THE PROLACTIN RECEPTOR AND SIGNAL TRANSDUCTION -- NEUROENDOCRINE CONTROL OF PROLACTIN SECRETION -- LACTOTROPH FUNCTION -- PATTERNS OF PROLACTIN SECRETION -- REPRODUCTIVE FUNCTIONS OF PROLACTIN -- PROLACTIN-INDUCED ADAPTIVE RESPONSES CONTRIBUTING TO SUCCESSFUL REPRODUCTION -- REPRODUCTIVE ACTIONS OF PROLACTIN IN THE MALE -- PROLACTIN AND REPRODUCTIVE DISORDERS -- CONCLUSION.

References -- Chapter 13 - Central Nervous System Control of Oxytocin Secretion during Lactation -- INTRODUCTION -- MILK EJECTION IN RESPONSE TO SUCKLING IS AN ATYPICAL NEURONAL REFLEX -- THE BEHAVIOR OF OT NEURONS DURING MILK EJECTION-THE RAT MODEL -- THE AFFERENT PATHWAY MEDIATING MILK EJECTION -- NEUROTRANSMITTERS/NEUROMODULATORS MEDIATING THE MILK EJECTION REFLEX -- ELECTROPHYSIOLOGICAL PROPERTIES OF OT NEURONS AND THEIR PLASTICITY DURING LACTATION -- SYNAPTIC PLASTICITY DURING LACTATION -- A MODEL FOR MILK EJECTION -- CONCLUSION -- Acknowledgments -- References -- SECTION 3 - MALE REPRODUCTIVE SYSTEM -- Chapter 14 - Testicular Development -- INTRODUCTION -- ANATOMICAL, HISTOLOGICAL, AND MORPHOMETRIC DEVELOPMENT -- CONTROL OF TESTIS DEVELOPMENT -- GERM CELLS -- TESTICULAR DEVELOPMENT AND ADULT HEALTH -- CONCLUSION -- References -- Chapter 15 - Spermatogonial Stem Cells and Spermatogenesis -- INTRODUCTION -- SPERMATOGONIAL STEM CELLS AND SPERMATOGENIC LINEAGE DEVELOPMENT -- EXPERIMENTAL TOOLS FOR STUDYING SPERMATOGONIAL STEM CELLS -- THE SPERMATOGONIAL STEM CELL NICHE -- MOLECULAR MECHANISMS GOVERNING SSC DEVELOPMENTAL FATE -- SPERMATOGONIAL STEM CELL AGING -- TRANSGENESIS -- REGENERATIVE POTENTIAL OF SPERMATOGONIAL STEM CELLS AND TRANSLATION TO THE CLINIC -- CONCLUSION -- Acknowledgments -- References -- Chapter 16 - Hormone Signaling in the Testis -- INTRODUCTION -- LUTEINIZING HORMONE -- TESTOSTERONE -- FOLLICLE-STIMULATING HORMONE -- THYROID HORMONE -- ESTROGEN -- ACTIVIN AND INHIBIN -- OTHER HORMONES -- CONCLUSION -- References -- Chapter 17 - The Epididymis -- INTRODUCTION -- DEVELOPMENT OF THE EPIDIDYMIS -- STRUCTURAL ORGANIZATION OF THE EPIDIDYMIS -- FUNCTIONS TAKING PLACE IN THE LUMINAL COMPARTMENT -- REGULATION OF EPIDIDYMAL FUNCTIONS -- MAJOR PROTEIN FAMILIES IN THE EPIDIDYMIS AND THEIR REGULATION -- AGING.

THE EPIDIDYMIS AS TARGET FOR XENOBIOTICS -- CONCLUSION -- Acknowledgments -- References -- Chapter 18 - Accessory Sex Glands in the Male -- INTRODUCTION -- ANATOMY AND HISTOLOGY -- EMBRYOLOGY AND DEVELOPMENT -- FUNCTION OF SEX ACCESSORY TISSUES -- REGULATION OF THE ADULT PROSTATE -- DISEASES OF THE PROSTATE GLAND -- CONCLUSION -- References -- Chapter 19 - The Immunophysiology of Male Reproduction -- INTRODUCTION -- STRUCTURE AND FUNCTION OF THE MALE REPRODUCTIVE TRACT RELEVANT TO IMMUNOPHYSIOLOGY -- THE IMMUNE SYSTEM AND ITS ENDOCRINE CONTROL -- IMMUNE CELLS OF THE MALE REPRODUCTIVE TRACT -- IMMUNOLOGICAL AND INFLAMMATORY MEDIATORS IN THE TESTIS -- EFFECTS OF IMMUNE CELLS AND INFLAMMATION ON MALE REPRODUCTION -- AUTOIMMUNITY IN THE MALE REPRODUCTIVE TRACT -- IMMUNE PRIVILEGE IN THE MALE REPRODUCTIVE TRACT -- INNATE IMMUNITY IN THE MALE REPRODUCTIVE TRACT: THE RESPONSE TO INFECTIONS AND TUMORS -- IMPLICATIONS, APPLICATIONS, AND THE NEXT 10YEARS -- CONCLUSION -- References -- SECTION 4 - FEMALE REPRODUCTIVE SYSTEM -- Chapter 20 - Gonadotropin Signaling in the Ovary -- INTRODUCTION -- FSH SIGNALS PROMOTE FOLLICULAR MATURATION -- FSH SIGNALING PATHWAYS THAT STIMULATE GRANULOSA CELL DIFFERENTIATION AND PROLIFERATION: CAMP AND PKA-DEPENDENT SIGNALING -- CROSS TALK AMONG FSH-REGULATED SIGNALING PATHWAYS AND TRANSCRIPTIONAL ACTIVATORS TO REGULATE GENE EXPRESSION DURING GRANULOSA CE... -- LH SIGNALS THAT REGULATE THECA CELL FUNCTIONS -- THE LH SURGE PROMOTES OOCYTE MATURATION, OVULATION, AND CORPUS LUTEUM FORMATION -- MECHANISMS BY WHICH LH STIMULATES OOCYTE MATURATION, OVULATION, AND LUTEINIZATION -- MOLECULAR BASIS FOR THE DIFFERENTIAL REGULATION OF TARGET GENE EXPRESSION BY FSH IN PREANTRAL AND LH IN PREOVULATORY GRANULOSA C... -- CONCLUSION -- Acknowledgments -- References -- Chapter 21 - Follicular Development: Mouse, Sheep, and Human Models.

INTRODUCTION -- MORPHOLOGY OF FOLLICULOGENESIS -- PRIMORDIAL FOLLICLE FORMATION -- THE PRIMORDIAL TO PRIMARY FOLLICLE TRANSITION -- REGULATION OF FOLLICULOGENESIS BY TGFΒ FAMILY SIGNALING IN THE OVARY -- TRANSCRIPTION FACTORS IN PREANTRAL-STAGE FOLLICULOGENESIS -- ANTRAL FOLLICLE DEVELOPMENT -- METABOLIC INFLUENCES ON FOLLICLE DEVELOPMENT -- CONCLUSION -- Acknowledgments -- References -- Chapter 22 - Ovulation -- INTRODUCTION -- OVULATION: A PERFORMANCE PLAYED BY MANY ACTORS -- SETTING THE STAGE: GRANULOSA CELL FUNCTIONS IN PREOVULATORY FOLLICLES -- ON-STAGE ACT I: LINKING THE LH RECEPTOR TO OTHER SIGNALING PATHWAYS IN GRANULOSA CELLS -- ON-STAGE ACT II: SIGNAL CONNECTIONS BETWEEN GRANULOSA CELLS AND THE CUMULUS CELL-OOCYTE COMPLEX DURING OVULATION -- ON-STAGE ACT III: THE OOCYTE REIGNS AT CENTER STAGE -- ON-STAGE ACT IV: KEY TRANSCRIPTION FACTORS THAT IMPACT OVULATION -- ON STAGE ACT V: KEY PROTEASES IN OVULATION -- ON STAGE ACT VI: CUMULUS CELLS HAVE IMMUNE-LIKE FUNCTIONS AND A DISTINCT FATE -- OFF-STAGE AND BEHIND THE SCENES: FOLLICLE ATRESIA AND GRANULOSA CELL APOPTOSIS -- TRANSLATIONAL CLINICAL CONSIDERATIONS -- CONCLUSION -- References -- Chapter 23 - Structure, Function, and Regulation of the Corpus Luteum -- INTRODUCTION -- CLASSIFICATION OF TYPES OF CORPORA LUTEA -- LUTEINIZATION -- LUTEOLYSIS -- REGULATION OF LUTEAL STRUCTURE AND FUNCTION -- LUTEAL CELL TYPES AND THEIR REGULATION -- CONCLUSION -- Acknowledgments -- References -- Chapter 24 - Human Oviduct and Endometrium: Changes over the Menstrual Cycle -- INTRODUCTION -- ANATOMY, EMBRYOLOGY, AND HISTOLOGY: AN OVERVIEW -- OVIDUCT -- ENDOMETRIUM -- CONCLUSION -- References -- Chapter 25 - Steroid Receptors in the Uterus and Ovary -- INTRODUCTION -- THE STEROID RECEPTORS -- SEX STEROID RECEPTORS IN UTERINE FUNCTION -- SEX STEROID RECEPTORS AND OVARIAN FUNCTION -- SUMMARY -- CONCLUSION.

References.

The Fourth Edition of Knobil & Neill continues to serve as a reference aid for research, to provide the historical context to current research, and most importantly as an aid for graduate teaching on a broad range of topics in human and comparative reproduction. In the decade since the publication of the last edition, the study of reproductive physiology has undergone monumental changes. Chief among these advances are in the areas of stem cell development, signaling pathways, the role of inflammation in the regulatory processes in the various tissues, and the integration of new animal models which have led to a greater understanding of human disease. The new edition synthesizes all of this new information at the molecular, cellular, and organismal levels of organization and present modern physiology a more understandable and comparative context. The Fourth Edition has been extensively revised, reflecting new fundamental advancements in this rapidly advancing field. Provides a common language for researchers across the fields of physiology, endocrinology, and biology to discuss their understanding of reproduction. Saves academic researchers time in quickly accessing the very latest details on reproductive physiology, as opposed to searching through thousands of journal articles.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2019. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.

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