Bioinspired and Biomimetic Polymer Systems for Drug and Gene Delivery. (Record no. 67243)

MARC details
000 -LEADER
fixed length control field 11471nam a22004933i 4500
001 - CONTROL NUMBER
control field EBC1884292
003 - CONTROL NUMBER IDENTIFIER
control field MiAaPQ
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20191126082656.0
006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS
fixed length control field m o d |
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION
fixed length control field cr cnu||||||||
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 191125s2015 xx o ||||0 eng d
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9783527672738
Qualifying information (electronic bk.)
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
Canceled/invalid ISBN 9783527334209
035 ## - SYSTEM CONTROL NUMBER
System control number (MiAaPQ)EBC1884292
035 ## - SYSTEM CONTROL NUMBER
System control number (Au-PeEL)EBL1884292
035 ## - SYSTEM CONTROL NUMBER
System control number (CaPaEBR)ebr10995099
035 ## - SYSTEM CONTROL NUMBER
System control number (CaONFJC)MIL674988
035 ## - SYSTEM CONTROL NUMBER
System control number (OCoLC)897810647
040 ## - CATALOGING SOURCE
Original cataloging agency MiAaPQ
Language of cataloging eng
Description conventions rda
-- pn
Transcribing agency MiAaPQ
Modifying agency MiAaPQ
050 #4 - LIBRARY OF CONGRESS CALL NUMBER
Classification number RS199.5 -- .G8 2015eb
082 0# - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 615.19
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Gu, Zhongwei.
9 (RLIN) 14347
245 10 - TITLE STATEMENT
Title Bioinspired and Biomimetic Polymer Systems for Drug and Gene Delivery.
250 ## - EDITION STATEMENT
Edition statement 1st ed.
264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE
Place of production, publication, distribution, manufacture Somerset :
Name of producer, publisher, distributor, manufacturer John Wiley & Sons, Incorporated,
Date of production, publication, distribution, manufacture, or copyright notice 2015.
264 #4 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE
Date of production, publication, distribution, manufacture, or copyright notice ©2014.
300 ## - PHYSICAL DESCRIPTION
Extent 1 online resource (362 pages)
336 ## - CONTENT TYPE
Content type term text
Content type code txt
Source rdacontent
337 ## - MEDIA TYPE
Media type term computer
Media type code c
Source rdamedia
338 ## - CARRIER TYPE
Carrier type term online resource
Carrier type code cr
Source rdacarrier
505 0# - FORMATTED CONTENTS NOTE
Formatted contents note Intro -- Bioinspired and Biomimetic Polymer Systems for Drug and Gene Delivery -- Contents -- List of Contributors -- Preface -- Chapter 1 Backbone Degradable and Coiled-Coil Based Macromolecular Therapeutics -- 1.1 Introduction -- 1.2 Water-Soluble Polymers as Carriers of Anticancer Drugs -- 1.2.1 First Generation Conjugates - Design, Synthesis, and Activity -- 1.2.2 Analysis of Design Factors That Need Attention -- 1.2.2.1 Design of Conjugates for the Treatment of Noncancerous Diseases -- 1.2.2.2 Combination Therapy Using Polymer-Bound Therapeutics -- 1.2.2.3 New Targeting Strategies -- 1.2.2.4 Relationship Between Detailed Structure of the Conjugates and Their Properties -- 1.2.2.5 Impact of Binding a Drug to a Polymer on the Mechanism of Action -- 1.2.2.6 Mechanism of Internalization and Subcellular Trafficking -- 1.2.2.7 Relationship Between the Molecular Weight of the Carrier and the Efficacy of the Conjugate -- 1.2.3 Design of Second Generation Conjugates - Long-Circulating and Backbone Degradable -- 1.2.3.1 RAFT Copolymerization for the Synthesis of Conjugates -- 1.2.3.2 Click Reactions for Chain Extension into Multiblock Copolymers -- 1.2.3.3 Biological Properties of Long-Circulating Macromolecular Therapeutics -- 1.2.4 Summary of Part 2 and Future Prospects -- 1.3 Drug-Free Macromolecular Therapeutics - A New Paradigm in Drug Delivery -- 1.3.1 Biorecognition in Hybrid Polymer Systems -- 1.3.2 Coiled-Coils in Biomedical Systems -- 1.3.3 Coiled-Coil Based Drug-Free Macromolecular Therapeutics: Design, In Vitro, and In Vivo Activity -- 1.3.4 Potential, Limitations, and Future Prospect of Drug-Free Macromolecular Therapeutics -- 1.4 General Summary and Outlook -- Acknowledgments -- References -- Chapter 2 Dendritic Polymers as Targeting Nanoscale Drug Delivery Systems for Cancer Therapy -- 2.1 Introduction.
505 8# - FORMATTED CONTENTS NOTE
Formatted contents note 2.2 Functional Dendritic Polymers Based Drug Delivery Vehicles for Targeting Tumor Therapy via EPR Effect -- 2.2.1 Functional Dendritic Polymers for Encapsulation of Anticancer Drugs -- 2.2.2 Chemical Conjugation Functional Dendritic Polymers as Drug Delivery Systems -- 2.3 Tumor Targeting Moieties Functionalized Dendritic Drug Delivery Vehicles for Cancer Therapy -- 2.4 Conclusion -- References -- Chapter 3 Composite Colloidal Nanosystems for Targeted Delivery and Sensing -- 3.1 Introduction -- 3.1.1 Working Toolkit -- 3.1.2 Engineering a Multifunctional Carrier -- 3.2 Objective -- 3.3 Cellular Behavior of the Carrier -- 3.3.1 Intracellular Fate -- 3.3.2 Biocompatibility -- 3.4 Applications -- 3.4.1 Delivery with Multifunctional PEM Capsules -- 3.4.1.1 Magnetic Targeting and Magnetofection -- 3.4.1.2 Strategies for Controlled Opening -- 3.4.2 Intracellular Ion Sensing -- 3.5 Conclusions -- Abbreviations -- References -- Chapter 4 Polymeric Micelles for Cancer-Targeted Drug Delivery -- 4.1 Introduction -- 4.2 Micelle Formulations in Clinical Development -- 4.3 Particle Size of Micelles -- 4.4 Morphology of Micelles -- 4.5 Targeting Design of Micelles for Enhanced Accumulation and Cell Internalization -- 4.6 Functional Designs of Micelles -- 4.7 Design of Micelles for Gene Delivery -- 4.8 Challenge and Future Perspective -- References -- Chapter 5 Biomimetic Polymers for In Vivo Drug Delivery -- 5.1 Introduction -- 5.2 Commonly Used Biomimetic Polymers and Their Applications in DDS -- 5.2.1 Polylactones and Their Modifications -- 5.2.1.1 Poly(lactic acid) (PLA) -- 5.2.1.2 Poly(lactic-co-glycolic acid) (PLGA) -- 5.2.1.3 Poly(ε-caprolactone) (PCL) -- 5.2.2 Dendrimer -- 5.2.2.1 Structure and Properties of Dendrimers -- 5.2.2.2 Types of Dendrimers -- 5.2.2.3 Applications of Dendrimers as Carriers in Drug Delivery Systems -- 5.2.3 Synthetic Polypeptides.
505 8# - FORMATTED CONTENTS NOTE
Formatted contents note 5.3 Challenges and Perspectives -- References -- Chapter 6 Drug Delivery from Protein-Based Nanoparticles -- 6.1 Introduction -- 6.2 Preparation of Protein-Based Nanoparticles -- 6.2.1 Desolvation -- 6.2.2 Emulsification -- 6.2.3 Coacervation -- 6.2.4 Polymer-Monomer Pair Reaction System -- 6.3 Drug Delivery from Albumin-Based Nanoparticles -- 6.3.1 Albumin-Based Nanoparticles as Drug Carriers -- 6.3.2 Targeting Ligand-Functionalized Albumin-Based Nanoparticles -- 6.3.3 Nanoparticle Albumin-Bound (nab) Technology -- 6.4 Drug Delivery from Gelatin-Based Nanoparticles -- 6.4.1 Gelatin-Based Nanoparticles as Drug Carriers -- 6.4.2 Targeting Ligand-Functionalized Gelatin-Based Nanoparticles -- 6.4.3 Site-Specific Drug Delivery System -- 6.5 Drug Delivery from Other Protein-Based Nanoparticles -- References -- Chapter 7 Polymeric Gene Carriers -- 7.1 Gene Therapy and Gene Carriers -- 7.1.1 Gene Therapy -- 7.1.1.1 The Concept of Gene Therapy -- 7.1.1.2 Development and the Present Situation of Gene Therapy -- 7.1.1.3 Methods and Strategies of Gene Therapy -- 7.1.1.4 Research Contents and Challenges of Gene Therapy -- 7.1.2 Gene Carriers -- 7.1.2.1 The Concept of Gene Carrier -- 7.1.2.2 The Necessity of the Gene Carrier -- 7.1.2.3 Requirements of Gene Carrier -- 7.1.2.4 Classification of Gene Carrier -- 7.2 Polymeric Gene Carriers -- 7.2.1 Cationic Polymer Gene Carriers -- 7.2.1.1 Process of the Polycation Vector Mediated Gene Delivery -- 7.2.1.2 Categories and Research Situation of the Cationic Polymer Gene Vector -- 7.3 PEI Grafting Modification Polymeric Gene Carriers -- 7.3.1 Amino Acid Derivatives Modified Polymeric Gene Carriers -- 7.3.1.1 Poly(glutamic acid) Derivatives Modified PEI -- 7.3.1.2 Polyphenylalanine Derivatives Modified PEI -- 7.3.2 PEG Modified Hyperbranched PEI -- 7.4 Low Molecular Weight (LWM) PEI Base Polymeric Gene Carriers.
505 8# - FORMATTED CONTENTS NOTE
Formatted contents note 7.4.1 Crosslinked Polycations -- 7.4.1.1 Crosslinked Polycation OEI-CBA -- 7.4.1.2 Crosslinked Polycation OEI-PBLG-PEGDA -- 7.4.1.3 Hexachlorotriphosphazene Crosslinked Polycation -- 7.4.2 Grafted Polycations -- 7.4.2.1 Grafted Cationic Polymer MP-g-OEI -- 7.4.2.2 Graft Cationic Polymer N-PAE-g-OEI -- 7.4.2.3 Graft Cationic Polymer mPEG-b-PMCC-g-OEI -- 7.5 Targeted Shielding System for Polymeric Gene Carriers -- 7.5.1 Static Shielding System -- 7.5.1.1 Poly(glutamine acid) Shielding System and PEGylations -- 7.5.1.2 Sulfonamides Related Shielding System -- 7.5.2 Other Design Strategies of Cationic Gene Carrier -- 7.6 Conclusion -- References -- Chapter 8 pH-Sensitive Polymeric Nanoparticles as Carriers for Cancer Therapy and Imaging -- 8.1 Introduction -- 8.2 pH-Sensitive Polymers -- 8.2.1 pH-Sensitive Anionic Polymers -- 8.2.2 pH-Sensitive Cationic Polymers -- 8.2.3 pH-Sensitive Neutral Polymers -- 8.3 pH-Sensitive Polymers as Drug Carriers -- 8.3.1 pH-Sensitive Polymer-Drug Conjugates -- 8.3.2 pH-Sensitive Polymeric Micelles -- 8.3.3 pH-Sensitive Polymersomes -- 8.3.4 pH-Sensitive Polymer-Inorganic Hybrid Nanoparticles -- 8.3.5 pH-Sensitive Dendrimers -- 8.4 pH-Sensitive Polymers for Bioimaging -- 8.5 Conclusions -- References -- Chapter 9 Charge-Reversal Polymers for Biodelivery -- 9.1 Applications of Cationic Polymers in Biodelivery -- 9.2 Barriers for Cationic Polymers in In vitro and In vivo Applications -- 9.3 Characteristic pH Gradients in Tumor Interstitium and Endo/Lysosomes -- 9.4 Chemistry of Charge-Reversal Polymers Based on Acid-Labile Amides -- 9.4.1 pHe-Triggered Charge-Reversal -- 9.4.2 pHL-Triggered Charge-Reversal -- 9.5 Applications of Charge-Reversal Polymers in Biodelivery Systems -- 9.5.1 Charge-Reversal in Cancer Drug Delivery -- 9.5.2 Charge-Reversal in Gene Delivery -- 9.5.3 Charge-Reversal in Protein Delivery.
505 8# - FORMATTED CONTENTS NOTE
Formatted contents note 9.5.4 Charge-Reversal Incorporated with Inorganic Materials -- 9.6 Perspectives -- References -- Chapter 10 Phenylboronic Acid-Containing Glucose-Responsive Polymer Materials: Synthesis and Applications in Drug Delivery -- 10.1 Introduction -- 10.2 PBA-Containing Polymers Operating Under Physiological Conditions -- 10.3 Chemically Crosslinked PBA-Based Gels -- 10.4 Self-Assembled PBA-Based Polymer Micelles -- 10.5 Self-Assembled PBA-Based Polymersomes -- 10.6 Perspectives -- References -- Chapter 11 Extracellular pH-Activated Nanocarriers for Enhanced Drug Delivery to Tumors -- 11.1 Introduction -- 11.2 Passive and Active Tumor Targeting -- 11.3 Targeting the Extracellular pH (pHe) in Tumors -- 11.4 Extracellular pH-Induced Drug Delivery to Tumors -- 11.5 Ligand Exposure by a Shielding/Deshielding Method -- 11.6 Surface Charge Reversing Nanoparticles -- 11.6.1 Enhanced Cellular Uptake by Surface Charge Reversing Nanoparticles -- 11.6.2 Overcoming MDR by Surface Charge Reversing Nanoparticles -- 11.6.3 Enhanced Delivery of siRNA by Surface-Charge Reversing Nanoparticles -- 11.7 Conclusion -- References -- Chapter 12 Stimulation-Sensitive Drug Delivery Systems -- 12.1 Introduction -- 12.2 pH-Sensitive Delivery Systems -- 12.2.1 pH-Sensitive Micellar Delivery Systems -- 12.2.2 pH-Sensitive Polymer- Drug Conjugates -- 12.2.3 pH-Sensitive Dendrimers -- 12.2.4 pH-Sensitive Liposomes -- 12.3 Thermo-Sensitive Delivery Systems -- 12.4 Biomolecule-Sensitive Delivery Systems -- 12.4.1 Enzyme-Sensitive Nanocarriers -- 12.4.2 Reduction- Responsive Conjugates -- 12.5 Other Environmentally Sensitive Nanocarriers -- 12.6 Outlook -- References -- Index -- EULA.
520 ## - SUMMARY, ETC.
Summary, etc. Here, front-line researchers in the booming field of nanobiotechnology describe the most promising approaches for bioinspired drug delivery, encompassing small molecule delivery, delivery of therapeutic proteins and gene delivery. The carriers surveyed include polymeric, proteinaceous and lipid systems on the nanoscale, with a focus on their adaptability for different cargoes and target tissues. Thanks to the broad coverage of carriers as well as cargoes discussed, every researcher in the field will find valuable information here.
588 ## - SOURCE OF DESCRIPTION NOTE
Source of description note Description based on publisher supplied metadata and other sources.
590 ## - LOCAL NOTE (RLIN)
Local note Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2019. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Drug delivery systems.
9 (RLIN) 14348
655 #4 - INDEX TERM--GENRE/FORM
Genre/form data or focus term Electronic books.
9 (RLIN) 14349
776 08 - ADDITIONAL PHYSICAL FORM ENTRY
Relationship information Print version:
Main entry heading Gu, Zhongwei
Title Bioinspired and Biomimetic Polymer Systems for Drug and Gene Delivery
Place, publisher, and date of publication Somerset : John Wiley & Sons, Incorporated,c2015
International Standard Book Number 9783527334209
797 2# - LOCAL ADDED ENTRY--CORPORATE NAME (RLIN)
Corporate name or jurisdiction name as entry element ProQuest (Firm)
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://ebookcentral.proquest.com/lib/thebc/detail.action?docID=1884292">https://ebookcentral.proquest.com/lib/thebc/detail.action?docID=1884292</a>
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