Poljsak, Borut.

Decreasing Oxidative Stress and Retarding the Aging Process. - 1 online resource (220 pages) - Aging Issues, Health and Financial Alternatives . - Aging Issues, Health and Financial Alternatives .

Intro -- DECREASING OXIDATIVE STRESS AND RETARDING THE AGING PROCESS -- DECREASING OXIDATIVE STRESS AND RETARDING THE AGING PROCESS -- Contents -- Preface -- Chapter I Introduction to the Aging Process -- 1.2. Aging Theories -- Telomere Theory -- Reproductive-Cell Cycle Theory -- Wear-And-Tear Theory -- Somatic Mutation Theory -- Error Accumulation Theory -- Evolutionary Theories -- Accumulative-Waste Theory -- Garbage Catastrophe Theory of Aging -- Autoimmune Theory -- Aging-Clock Theory -- Cross-Linkage Theory -- Free-Radical Theory -- Reliability Theory of Aging and Longevity -- Mitohormesis -- Misrepair-Accumulation Theory and Others -- Chapter II Description of the Problem -- 2.1. Reactive Oxygen Species (ROS) and the Oxidative Stress -- Oxidative Stress -- The (Im)Balance between ROS Production and Antioxidative Defense -- 2.1.1. Major Forms of ROS in Biological Systems -- Superoxide (O2˙-) -- Hydrogen Peroxide (H2O2) -- Hydroxyl Radical (OH˙) -- 2.1.2. ROS as a Cause of the Oxidative Damage -- DNA -- Lipids -- Proteins -- 2.2. Defenses AgainstROS -- 2.2.1. Primary Endogenous Antioxidant Defenses -- Superoxide Dismutase (SOD) -- Catalase -- Glutathione Peroxidase (GPx) -- Glutathione-Related Systems -- 2.2.2. Secondary Antioxidant Defenses -- Exogenous Antioxidant Defenses: Compounds Derived from the Diet -- Chapter III Metabolic Rate and Lifespan -- Chapter IV The Evolutionary Reasons for Not Perfecting the Prevention of Free Radical Formation -- 4.1. Reactive Oxygen Species and Famine -- Caloric Restriction and Evolution -- 4.2. Reactive Oxygen Speciesand Infections -- 4.3. Reactive Oxygen Species in Cell Signaling -- 4.4. Reactive Oxygen Species and Evolution -- Chapter V Methods to Decrease Oxidative Stress and Retard the Aging Process -- 5.1. Mitochondrial Uncoupling -- 5.1.1. Uncoupling and Heat Production. 5.2. The Role of Macro- and Micronutrients -- 5.2.1. Metal Ions thatCan Increase ROS in Cells -- 5.3. The Induction of Adaptive Responses to Stress Conditions: The Role of Hormesis Effect as an Example of a Beneficial Type of Stress -- 5.3.1. Caloric Restriction and Reactive Oxygen Species -- Caloric Restriction Mimetics -- 5.3.2. Exercise and Reactive Oxygen Species -- 5.4. Food and ROS Formation -- 5.4.1. Foods that Increases Reactive Oxygen Species Formation -- Side-Effects of Processed Food -- Alcohol -- Avoidance of Excessive Sugar Intake -- Avoidance of Intake of Chlorinated Water -- 5.4.2. Foods that Decreases Oxidative Stress -- Teas -- Mediterranean Diet (MD) -- Red Wine and Resveratrol -- At Least Five Portions of Fruits and Vegetables Per Day -- The Problem of ORAC Units -- 5.4.3. Nutrition and Inflammation -- Acute Inflammation -Free Radicals Help in Fighting Infection -- Free Radicals as "Good Guys" -- The Problem of Chronic Inflammation -- Chronic Inflammation and Protective Role of Antioxidants -- Inflammation and Cancer -- Foods to Calm Inflammation -- Blueberries -- Mexican Red Bean -- Prunes -- Milk Thistle Extract -- Curcumin -- Ginkgo Biloba Extract -- Propolis -- Resveratrol -- Green Tea -- Sinthetic Antioxidants -- Foods to Avoid -- Eating for Optimal Nutrition -- Overweight and Inflammation -- 5.4.4. The Importance of Eating Habits -- Number of Meals in Regard to Electron Transport in Mitochondria -- 5.5. The Importance of Lifestyle -- 5.5.1. Sleeping and Melatonine Production -- 5.5.2. Avoidance of Polluted Environments -- 5.5.3. Avoid Excessive Psycho-Physical Stressful Situations -- 5.6. Can Antioxidants as Dietary Supplements Offer Appropriate Protection Against ROS-Induced Damage? -- 5.6.1. Antioxidants and Clinical Trials -- Endogenous Antioxidants -- Intake of Exogenous Antioxidants. Pro-Oxidant Activities of Antioxidants -- Should Supplements of Antioxidants Be Taken? -- Chapter VI How Do Methods Claiming to Decrease Oxidative Stress Compare with Studies on Long-Lived Populations? -- 6.1. Intrinsic Factors (Genes) vs. Extrinsic Factors (Lifestyle and Environment) - What's the Centenarians' Secret? -- Chapter VII Methodology for the Detection of Oxidative State in Biological Systems -- Measurement of Total Antioxidant Status -- The Assessment of Antioxidant Status: The BAP Test -- Who Should Be Tested? -- Chapter VIII Conclusion -- Acknowledgement -- About the Author of the Book -- References -- Index.

9781613249437


Oxidative stress.;Aging -- Physiological aspects.;Antioxidants -- Physiological effect.


Electronic books.

RB170 -- .P65 2010eb

616.3/9